Flexible Bioactive Glass Nanofiber-Based Self-Expanding Cryogels with Superelasticity and Bioadhesion Enabling Hemostasis and Wound Healing.

Self-expanding cryogels hold unique prospects for treating uncontrollable hemorrhages. However, development of a mechanically robust, tissue-adhesive, and bioactive self-expanding cryogel enabling effective hemostasis and tissue repair has remained a great challenge. Herein, we report a superelastic cellular-structured bioactive glass nanofibrous cryogel (BGNC) composed of highly flexible BG nanofibers and citric acid-cross-linked poly(vinyl alcohol).

Nanofibrous hemostatic materials: Structural design, fabrication methods, and hemostatic mechanisms.

Development of rapid and effective hemostatic materials has always been the focus of research in the healthcare field. Nanofibrous materials which recapitulate the delicate nano-topography feature of fibrin fibers produced during natural hemostatic process, offer large length-to-diameter ratio and surface area, tunable porous structure, and precise control in architecture, showing great potential for staunching bleeding. Here we present a comprehensive review of advances in nanofibrous hemostatic materials, focusing on the following three important parts: structural design, fabrication methods, and hemostatic mechanisms.

Stretchable, tough and elastic nanofibrous hydrogels with dermis-mimicking network structure.

Nanofiber-structured hydrogels with robust mechanical properties are promising candidates for the development of multifunctional materials in advanced fields. However, creating such materials that combine the virtues of high elongation, robust strength, and good elasticity remains an enormous challenge. Here, we demonstrate a nature-inspired methodology to fabricate dermis-mimicking network structured electrospun nanofibrous hydrogels with robust mechanical properties by combining the advantages of sustainable plant-based zein and elastic waterborne polyurethane (WPU).