Publications by authors named "Xuyan Guan"
Brainstem opioid peptidergic neurons regulate cough reflexes in mice.
Innovation (Camb)
November 2024
Article Synopsis
- - Coughing serves as a protective reflex to remove harmful substances from the airway, but how the brain processes this reflex isn't fully understood.
- - Researchers created a method to quantitatively assess cough-like reflexes in mice and discovered that specific neurons in the nucleus of the solitary tract (NTS) play a critical role in these reflexes.
- - The activation of these NTS neurons, which receive signals from vagal sensory neurons, triggers respiratory responses similar to coughing, highlighting their importance in initiating cough-like reflexes via a specific neural pathway to the cough center in the brain.
Article Synopsis
- * Research used various test models to explore how MCRT works on different pain types and found it interacts with specific receptors in unique ways, leading to different pain relief results.
- * Importantly, MCRT reduces the risk of tolerance and addiction, making it a potential alternative that could help manage chronic pain and contribute to solving the opioid crisis.
Panic disorder is a psychiatric disorder characterized by recurrent panic attacks, with a prevalence of ~ 4% in the general population, causing heavy personal and socioeconomic burdens. The similarities of animal defense responses to clinical panic attack symptoms in humans make it possible to translate neuroanatomical pathways identified in animal studies to panic disorder in humans. Therefore, in this review we first present a basic overview of panic disorder in humans including the main subtypes, models commonly used to trigger panic attacks, related hypotheses, the neurotransmitter systems that may be involved, and the current clinical treatments to give the reader a comprehensive understanding of panic disorder.
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