Publications by authors named "Xuxue Dong"
The entry of coronaviruses is initiated by spike recognition of host cellular receptors, involving proteinaceous and/or glycan receptors. Recently, TMPRSS2 was identified as the proteinaceous receptor for HCoV-HKU1 alongside sialoglycan as a glycan receptor. However, the underlying mechanisms for viral entry remain unknown.
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- Receptors and their ligands are crucial in about one-third of drugs on the market, and this study explores a method to develop antibodies that influence the signaling of these receptors.
- Researchers focused on CXCR2, a type of G-protein coupled receptor, and successfully selected a highly effective antibody that binds to a specific region of the receptor using a small antibody library.
- The findings suggest that this antibody can inhibit neutrophil movement linked to various diseases, indicating its potential as a therapeutic agent similar to anti-TNF antibodies, but with a unique approach by targeting the receptor itself rather than the ligand.