Publications by authors named "Xuxia Tang"
Article Synopsis
- Gentamicin, a widely used antibiotic, can cause ototoxicity, disrupting balance, so this study examined the effects of gastrodin from Gastrodia on gentamicin-induced vestibular dysfunction.
- The research involved testing mice that were divided into control, gentamicin, and gentamicin + gastrodin groups, assessing vestibular function and analyzing cellular changes related to damage and apoptosis.
- Results showed that while gentamicin caused significant vestibular impairment and hair cell loss, gastrodin pretreatment reduced these effects by inhibiting the Notch signaling pathway, indicating its potential as a protective treatment against vestibular dysfunction.
Article Synopsis
- Eczematous external otitis (EEO) is a challenging condition characterized by itchy inflammation in the external ear canal, often linked to dermatological or allergic responses, including potential food allergies, although the role of food-specific IgG4 is still not fully understood.
- A 54-year-old woman with EEO experienced persistent itching and chapped hands for several years and was treated through a diet elimination approach that removed egg, milk, and wheat, alongside probiotics, based on her food-specific IgG4 results.
- After 17 months of this treatment, she reported complete relief from symptoms, with food-specific IgG4 levels returning to normal, highlighting the potential importance of food allergens and diet in EEO management.
Article Synopsis
- Ixekizumab is an IL-17A inhibitor used to treat psoriasis but can cause side effects like injection site reactions and rare cases of inflammatory bowel disease or mucosal ulcers.
- A case study of a 51-year-old man showed he developed multiple mucosal ulcers after ixekizumab treatment, which did not respond to standard treatment.
- The ulcers were recognized as an immune-related adverse event; after discontinuing ixekizumab and starting corticosteroids and thalidomide, the patient's symptoms improved.
Challenges in Diagnosing and Treating Subperiosteal Orbital Hematoma Secondary to Sinusitis: A Case.
Ear Nose Throat J
September 2024
Subperiosteal orbital hematoma secondary to sinusitis is rare. Thus far, 19 cases of this disease have been reported, of which none involved postoperative skin anesthesia in the region innervated by the supraorbital nerve. In this article, for the first time we report a case of subperiosteal orbital hematoma secondary to sinusitis with skin anesthesia in the area innervated by the supraorbital nerve after surgery.
View Article and Find Full Text PDFThis study investigated the nonlinear associations between neutrophil-to-lymphocyte (NLR)/platelet-to-lymphocyte (PLR) and recovery rates in sudden sensorineural hearing loss (SSNHL). Total of 244 SSNHL patients were included. The primary outcome was recovery rate.
View Article and Find Full Text PDFBackground: Abnormal dynamics of the Golgi apparatus reshape the tumor microenvironment and immune landscape, playing a crucial role in the prognosis and treatment response of cancer. This study aims to investigate the potential role of Golgi apparatus-related genes (GARGs) in the heterogeneity and prognosis of head and neck squamous cell carcinoma (HNSCC).
Methods: Transcriptional data and corresponding clinical information of HNSCC were obtained from public databases for differential expression analysis, consensus clustering, survival analysis, immune infiltration analysis, immune therapy response assessment, gene set enrichment analysis, and drug sensitivity analysis.
Background: Cerebellopontine angle lipoma is a rare tumor that composes less than 1% of all CPA tumors. There has been no recorded case of unilateral CPA/IAC lipoma with sudden contralateral deafness yet.
Case Presentation: We report a 52-year-old man diagnosed with right cerebellopontine angle lipoma and combined left total deafness.
Background: Habituation learning is a simple and conserved behavior in all organisms which could be induced by repeated stimuli. However, no standard and universal methods for training and evaluating the habituation learning behavior in larval zebrafish were available.
New Method: This study aims to establish effective training and detection protocols for habituation learning behavior in larval zebrafish by using the ViewPoint system.
Suppression of Long Noncoding RNA SNHG1 Inhibits the Development of Hypopharyngeal Squamous Cell Carcinoma via Increasing PARP6 Expression.
Evid Based Complement Alternat Med
July 2022
Purpose: This study aimed to explore the function and molecular mechanism of long noncoding RNA Small Nucleolar RNA Host Gene 1 (SNHG1) in the development of hypopharyngeal squamous cell carcinoma (HSCC).
Methods: Human HSCC cell line FaDu was used in this study. Cell viability and apoptosis were detected using CCK-8 assay and flow cytometry, respectively.
Objective: The objective of this study was to investigate whether long noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) contributes to laryngocarcinoma development via regulating the Yes-associated protein 1- (YAP1-) mediated epithelial-mesenchymal transition (EMT) and the underlying mechanism.
Methods: The effects of MALAT1 suppression and BET inhibitor JQ1 on the malignant phenotypes and cancer stem cell- (CSC-) like properties of laryngocarcinoma cells as well as the expression of bromodomain-containing protein 4 (BRD4), YAP1, and EMT markers were investigated. Moreover, the relationships between MALAT1 and miR-708-5p as well as between miR-708-5p and BRD4 were explored.
Sensorineural hearing loss is prevalent in patients receiving cisplatin therapy. Tetramethylpyrazine (Tet) and tanshinone IIA (Tan IIA) have protective roles against hearing impairment or ototoxicity. The present study aimed to investigate the molecular mechanisms underlying cisplatin‑induced ototoxicity and the protective effect of Tet and Tan IIA against it.
View Article and Find Full Text PDFPurpose: Ineffective use of continuous positive airway pressure (CPAP) therapy can result in inconvenience and additional costs in patients with obstructive sleep apnea (OSA). This study investigated the predictive value of body mass index (BMI) to assess the efficacy of CPAP in patients with OSA.
Methods: Data were extracted from a retrospective study performed in Silkeborg Hospital.
Triptolide induces toxicity in inner ear stem cells via promoting DNA damage.
Toxicol In Vitro
December 2019
Emerging evidence and clinical case reports have observed a risk of cytotoxic effects of triptolide in patients. We aimed to investigate the triptolide-induced toxicity in mouse inner ear stem cells. The utricular sensory epithelium from adult BALB/C6 mice was used for the isolation of inner ear stem cells.
View Article and Find Full Text PDFThe aim of the present study was to investigate the effects of shikonin (SHI) on the induction of apoptosis in human TT medullary thyroid carcinoma cells, and to explore the role of mitochondrial signaling in this process. MTT, Annexin V‑phycoerythrin/7‑aminoactinomycin D staining, electron microscopy and JC‑1 probe staining were performed to analyze mitochondrial membrane potential, and western blot analysis was used to examine the activation of the mitochondrial signaling pathway, and the changes in mitochondrial apoptosis pathway‑associated protein expression. Following culture for 24‑72 h, treatment with various concentrations of SHI inhibited the proliferation of TT cells, in a dose‑ and time‑dependent manner.
View Article and Find Full Text PDFPurpose: In the present study, we made an attempt to elucidate the role of oversecretion of interleukin-4 (IL-4) in cancer stem cells (CSCs) of head and neck squamous cell carcinoma (HNSCC).
Methods: HNSCC samples were analyzed for the presence of CSCs by flow cytometry. In addition, we have performed drug and apoptosis resistance assays to determine the role of IL-4 in CSCs.