Publications by authors named "Xuwen Alice Zheng"
Article Synopsis
- Researchers developed a method called MIPSA that helps identify harmful antibodies in COVID-19 patients by using proteins linked to DNA barcodes!*
- The study screened over 11,000 proteins and found two types of neutralizing autoantibodies related to type-I and type-III interferon in patients with severe COVID-19 responses!*
- MIPSA is cost-effective and user-friendly, enabling large-scale studies of various biological interactions, which could aid in understanding disease mechanisms better!*
Article Synopsis
- * The study introduces MIPSA, a technique that creates extensive protein libraries tagged with unique DNA barcodes for detailed analysis through sequencing.
- * Using MIPSA, researchers analyzed autoantibodies in 55 severe COVID-19 patients, confirming known autoantibodies and discovering new ones, specifically anti-IFN-λ3, which could lead to potential therapies for at-risk individuals.
Background: Myositis, or idiopathic inflammatory myopathy (IIM), is a group disorders of unknown etiology characterized by the inflammation of skeletal muscle. The role of T cells and their antigenic targets in IIM initiation and progression is poorly understood. T cell receptor (TCR) repertoire sequencing is a powerful approach for characterizing complex T cell responses.
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