Publications by authors named "Xupeng Yue"
Tumor derived Extracellular vesicles (EVs) in circulating system may contain tumor-specific markers, and EV detection in body fluids could become an important tool for early tumor diagnosis, prognosis assessment. Meningiomas are the most common benign intracranial tumors, few studies have revealed specific protein markers for meningiomas from patients' body fluids. In this study, using proximity labeling technology and non-tumor patient plasma as a control, we detected protein levels of EVs in plasma samples from meningioma patients before and after surgery.
View Article and Find Full Text PDFArticle Synopsis
- The review discusses the recent progress in understanding how nanomaterials (NMs) can induce a type of cell death called pyroptosis in various cell types, emphasizing its mechanisms and classifications.
- It also analyzes how different NMs affect non-tumorous cells and points out the multifunctionality of NMs in regulating cell death pathways.
- The authors highlight research gaps and suggest new areas to explore, including NM-triggered pyroptosis in non-tumor cells, interactions with biological and environmental factors, and the overall NM-cell interactions for safer nanomedical applications.
The dysregulation of microRNAs (miRNAs) is associated with the development and progression of a variety of cancers, including liver cancer. Aberrant expression of miRNA (miR)‑124 has been demonstrated in liver cancer, but its functional mechanism in liver cancer is still largely unknown. Metastasis of liver cancer is one of the most common causes of mortality.
View Article and Find Full Text PDFOptimization and biological evaluation of nicotinamide derivatives as Aurora kinase inhibitors.
Bioorg Med Chem
September 2019
Article Synopsis
- Aurora kinases are often overexpressed in solid tumors and play a role in cancer development and growth.
- Researchers synthesized nicotinamide derivatives to test their effectiveness as inhibitors of Aur A and Aur B, along with their antitumor effects on various cancer cell lines.
- The most effective compound, 10l, demonstrated strong antitumor activity with lower inhibitory concentration values compared to a reference compound and showed better binding interactions with Aur A.
Article Synopsis
- - A new series of thiazolidine-4-one urea compounds were created and tested for their effectiveness against cancer cells, specifically focusing on their structure-activity relationships and binding properties.
- - The most effective compound, 17b, demonstrated strong potency against A549 and HT-29 cancer cell lines, with IC values indicating very low concentrations were needed to inhibit cell growth.
- - Compound 17b acts as a multikinase inhibitor, successfully targeting FLT3 and VEGFR2, and showed significant anti-cancer effects by inducing cell death and preventing cell migration, outperforming the standard drug Cabozantinib.
Article Synopsis
- Somatic mutations in the HIF2A gene are linked to polycythemia-paraganglioma syndrome, particularly affecting females with conditions like recurrent paragangliomas and early childhood polycythemia.
- Research analyzed the relationship between HIF2A mutations and the clinical features of affected patients, noting significant differences in age at symptom onset.
- The study found that while somatic HIF2A mutations were present, no mosaicism was detected in blood DNA, indicating that the absence of mosaicism is associated with a milder disease presentation and better outcomes compared to those with HIF2A mosaicism.
Article Synopsis
- - A new series of 21 N-(2-aryl-1,3-thiazolidin-4-one)-N-aryl urea derivatives were developed from a previously identified lead compound, with compound 19a showing the most potential as a multi-tyrosine kinase inhibitor.
- - Compound 19a demonstrated significant cytotoxic and anti-proliferative effects on HT-29 cancer cells, outpacing the effectiveness of the existing drug Cabozantinib in both time and dosage studies.
- - The anticancer properties of compound 19a were linked to increased cancer cell apoptosis and the inhibition of key signaling pathways (c-Met, ERK, and Akt), while also enhancing the migration prevention of HT
Article Synopsis
- A total of 29 new compounds featuring N-(2-aryl-1, 3-thiazolidin-4-one)-N-aryl ureas were created and tested for biological activity.
- The study clarified the structure-activity relationships (SARs) and how these compounds bind to their targets.
- Among the compounds, 29b showed strong effectiveness against several multi-tyrosine kinases and was confirmed to inhibit growth and kill A549 cancer cells using live-cell imaging technology.
Article Synopsis
- Researchers developed a new multi-kinase inhibitor called CS2164, targeting key pathways involved in tumor growth and angiogenesis.
- CS2164 effectively inhibited several key kinases, resulting in reduced tumor blood vessel formation, cell proliferation, and differentiation of immune cells in tumors.
- In animal studies, CS2164 showed significant tumor growth inhibition and regression at manageable doses, suggesting potential as a promising cancer treatment.
Aberrant microRNA (miRNA) expression has been frequently observed in colorectal cancer (CRC), the third most common human cancer in the world. However, the roles of miRNAs in CRC remain poorly understood. The present study explored, identified and characterized the miRNAs that correlate with CRC progression.
View Article and Find Full Text PDFCombination of low doses of histone deacetylases inhibitors and chemotherapy drugs is considered as one of the most promising strategies to increase the anticancer efficacy. Chidamide is a novel benzamide chemical class of HDAC inhibitor that selectively inhibited HDAC1, 2, 3 and 10. We sought to determine whether chidamide may enhance platinum-induced cytotoxicity in NSCLC cells.
View Article and Find Full Text PDFMicroRNA-124 suppresses growth of human hepatocellular carcinoma by targeting STAT3.
Biochem Biophys Res Commun
November 2013
Article Synopsis
- Aberrant microRNA expression is linked to cancer development, and specifically, miR-124 is down-regulated in hepatocellular carcinoma (HCC), but its role in tumor suppression is not fully understood.
- This study reveals that miR-124 inhibits HCC tumor growth by targeting and down-regulating the STAT3 protein, which plays a crucial role in cell proliferation and survival.
- The findings suggest that miR-124 acts as a tumor suppressor in HCC and could potentially be used as a biomarker for diagnosis and treatment strategies.
Emerging evidence indicate that microRNAs (miRNAs) may play important roles in cancer. Aberrant expression of miRNAs has been frequently identified in different human malignancies, including colorectal cancer (CRC). However, the mechanism by which deregulated miRNAs impact the development of CRC remains largely elusive.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the relationship between copy number variations (CNVS) in Th17 cell-related genes and the risk of systemic lupus erythematosus (SLE), an autoimmune disease.
- By analyzing genetic material from 938 SLE patients and 1,017 healthy individuals, the researchers focused on specific genes linked to Th17 cells, such as IL-17F, IL-21, and IL-22.
- Results showed that SLE patients had significantly higher frequencies of CNVS for these genes compared to healthy controls, suggesting a potential genetic risk factor for the disease.
Copy number variations of Interleukin-12B and T-bet are associated with systemic lupus erythematosus.
Rheumatology (Oxford)
July 2011
Article Synopsis
- The study investigates the link between copy number variations (CNVs) in Th1 cell-related genes and the risk of systemic lupus erythematosus (SLE), an autoimmune disease.
- It involved analyzing DNA and RNA from over 500 SLE patients and healthy individuals, focusing on specific genes related to Th1, Th2, and Treg cells.
- Results showed higher CNVs of the IL-12B and T-bet genes in SLE patients compared to controls, suggesting these variations may contribute to the disease's risk.
The follicle-stimulating hormone (FSH) acts on the Sertoli cells in the seminiferous tubules of the testis and regulates spermatogenesis up to the secondary spermatocyte stage. This study aimed to investigate molecular genetic characteristics of the bovine FSH beta-subunit gene (FSHB) and elucidate the effects of single nucleotide polymorphisms (SNPs) of FSHB on the quality of fresh and frozen semen and on fertility in bulls. We used polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) and sequencing of the FSHB gene in 56 bulls belonging to three breeds.
View Article and Find Full Text PDF