BMSC seeding in different scaffold incorporation with hyperbaric oxygen treats seawater-immersed bony defect.

Introduction: The experiment was undertaken to estimate the effect of BMSC seeding in different scaffold incorporation with HBO on the repair of a seawater-immersed bone defect. And future compared n-HA/PLGA with β-TCP/PLGA as a scaffold in treatment effect of the seawater-immersed bone defect.

Methods: Sixty New Zealand White rabbits with standard seawater defect in radius were randomly divided into group A (implant with nothing), group B (implanted with autogenous bone), group C (implanted with n-HA/PLGA/BMSCs), and group D (implanted with β-TCP/PLGA/BMSCs).

Effects of hyperbaric oxygen therapy on open tibial fractures in rabbits after transient seawater immersion.

Objective: To explore the effect and mechanism of hyperbaric oxygen (HBO₂) therapy of open tibial fractures in rabbits after transient seawater immersion.

Methods: Forty-eight (48) New Zealand rabbits were randomly and averagely divided into an HBO₂ therapy group (Group A) and a control group (Group B). All rabbits were subjected to unilateral open tibial fractures, while immersed in artificial seawater (20-22 °C) for three hours prior to debridement and external fixation.