Nuclei-level prior knowledge constrained multiple instance learning for breast histopathology whole slide image classification.

New breast cancer cases have surpassed lung cancer, becoming the world's most prevalent cancer. Despite advancing medical image analysis, deep learning's lack of interpretability limits its adoption among pathologists. Hence, a nuclei-level prior knowledge constrained multiple instance learning (MIL) (NPKC-MIL) for breast whole slide image (WSI) classification is proposed.