Publications by authors named "Xunbo Yang"
The role of TFEB-mediated autophagy-lysosome dysfunction in manganese neurotoxicity.
Curr Res Toxicol
September 2024
Article Synopsis
- Long-term manganese exposure can cause serious and lasting damage to the nervous system, especially affecting key pathways in brain regions associated with movement.
- Research using mice revealed that manganese disrupts a process called autophagy-lysosome function, leading to neurotoxicity and abnormal protein buildup in neurons.
- The study highlights the role of a protein called TFEB in this dysfunction, suggesting it could serve as an early marker for manganese exposure, helping in preventive measures and treatments for those at risk.