Publications by authors named "Xunan Zhu"
Long non-coding RNA OIP5-AS1 protects neurons from ischemia-reperfusion injury and inhibits neuronal apoptosis through TAB-2.
Biochem Biophys Res Commun
January 2025
Ischemic stroke represents a highly perilous cerebrovascular disorder, involving a variety of complex pathophysiological mechanisms. OIP5 antisense RNA 1 (OIP5-AS1) is a long non-coding RNA (LncRNA) that has been shown to play a pivotal role in a variety of disease systems. However, there are relatively few studies on ischemic stroke.
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- * In a study examining mice 14 days post-ICH, researchers found three unique expression patterns in microglia linked to different functions: one similar to Disease-Associated Microglia (DAM) from Alzheimer's, another related to new blood vessel formation (angiogenesis), and a third reflecting the M1 inflammatory state.
- * Analysis also indicated that microglia involved in lipid metabolism and phagocytosis may originate from actively dividing cells shortly after ICH, suggesting that targeting these specific microgl
Subarachnoid Hemorrhage (SAH) is a cerebrovascular disorder that has been found to have severe consequences, including a high mortality and disability rate. Research has indicated that neuronal death, particularly apoptosis, plays a major role in the neurological impairment that follows SAH. RNA-binding protein Pum2 can interfere with translation or other biological functions by connecting to the UGUAHAUA sequence on RNA.
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