Publications by authors named "Xun-Min Cheng"
Article Synopsis
- The study aimed to understand how epicardial adipocytes change their characteristics during the development of coronary atherosclerosis, focusing on potential molecular mechanisms.
- The experiment involved 30 male rabbits divided into two groups: one group was fed a high-fat diet to induce atherosclerosis, while the control group received normal food.
- Results showed a decrease in essential fat-burning markers (UCP-1 and PPARγ) and an increase in leptin, indicating a shift in adipose tissue phenotype; IL-6 was identified as a key factor in this conversion through the JAK-STAT3 signaling pathway.
Objective: To investigate the correlation of CTRP9 with coronary atherosclerosis.
Methods: Coronary angiography confirmed CAD in 241 patients (62 received CABG) and non-CAD in 121 (55 received valve replacement).
Results: Serum levels of LDL-C, CRP, TNF-α, IL-6, and leptin in CAD patients were significantly higher than those in non-CAD patients (P < 0.
[Membrane testosterone receptors in cultured vascular smooth muscle cells].
Zhonghua Nan Ke Xue
May 2010
Objective: To determine the presence of membrane testosterone receptors in cultured vascular smooth muscle cells (VSMC), and investigate their relationship with classical intracellular androgen receptors (iAR).
Methods: VSMCs were cultured from the thoracic aorta of male Sprague-Dawley rats by the explant method. Subconfluent VSMCs were incubated with serum-free medium for 24 h to obtain quiescent non-dividing cells, and then treated with the indicated agents.
Objective: To explore the acute effects of testosterone at the physiological level on PGF2alpha-induced increase in intracellular Ca2+ in cultured vascular smooth muscle cells (VSMCs).
Methods: VSMCs from the thoracic aorta of male Sprague-Dawley rats were cultured using the explant method. The subconfluent VSMCs were incubated with serum-free medium for 24 hours to obtain quiescent non-dividing cells and then treated with the indicated agents.