Transmembrane transports of acrylamide and bisphenol A and effects on development of zebrafish (Danio rerio).

Acrylamide (AA) and bisphenol A (BPA) are two kinds of pollutants with different structures and polarities. AA found in fried and toasted starchy foods can cause developmental and reproductive toxicity and BPA has neuro-, immuno- and developmental toxicities. Their transports in zebrafish (Danio rerio) embryos were determined and their toxicity characteristics observed.

Binding of bisphenol A and acrylamide to BSA and DNA: insights into the comparative interactions of harmful chemicals with functional biomacromolecules.

The interactions between bisphenol A (BPA)/acrylamide (AA) and bovine serum albumin (BSA)/deoxyribonucleic acid (DNA) was investigated by the equilibrium dialysis, fluorophotometry, isothermal titration calorimetry (ITC) and circular dichroism (CD). The bindings of BPA and AA to BSA and DNA responded to the partition law and Langmuir isothermal model, respectively. The saturation mole number of AA was calculated to be 24 per mol BSA and 0.

Binding of PFOS to serum albumin and DNA: insight into the molecular toxicity of perfluorochemicals.

Background: Health risk from exposure of perfluorochemicals (PFCs) to wildlife and human has been a subject of great interest for understanding their molecular mechanism of toxicity. Although much work has been done, the toxigenicity of PFCs remains largely unknown. In this work, the non-covalent interactions between perfluorooctane sulfonate (PFOS) and serum albumin (SA) and DNA were investigated under normal physiological conditions, aiming to elucidate the toxigenicity of PFCs.