Combination of Ethacrynic Acid and ATRA Triggers Differentiation and/or Apoptosis of Acute Myeloid Leukemia Cells through ROS.

Background And Objective: All-trans retinoic acid (ATRA), an effective differentiation inducer, has been applied clinically to treat acute promyelocytic leukemia (APL). Unfortunately, it is not as potent in other kinds of acute myeloid leukemia (AML). Ethacrynic acid (EA), a classical powerful diuretic, can increase reactive oxygen species (ROS) contents, which can assist ATRA in inducing differentiation in AML cells.

Posttraumatic arteriovenous fistula of the lower extremity and the pathological characteristic-case series and literature review.

The clinical presentation, treatment history, and outcomes of two patients with posttraumatic arteriovenous fistula (PTAVF) were analyzed and compared with the pathological tissues of patients with hemodialysis arteriovenous fistula (HAVF). A search of the biomedical literature database (PubMed), using the keywords " lower extremity" and "PTAVF," was conducted to obtain results and review the data. Postoperative histological analysis of patients with PTAVF showed differences from that of HAVF.

Nursing model based on Snyder's hope theory in emergency care of patients with acute myocardial infarction.

Objective: To investigate the effect of Snyder's hope theory in emergency care for patients with acute myocardial infarction (AMI).

Methods: This retrospective study included 200 AMI patients admitted to Rugao People's Hospital from January 2019 to December 2021. The patients were divided into a conventional group (routine care, n=100) and an intervention group (care based on Snyder's Hope theory, n=100) according to differences in nursing approach.

Phase separation is required for PML nuclear body biogenesis and function.

PML nuclear body (NB) malfunction often leads to acute leukemia outbreaks and other severe diseases. PML NB rescue is the molecular basis of arsenic success in acute promyelocytic leukemia (APL) treatment. However, it is unclear how PML NBs are assembled.

Assessing the option water-saving willingness of irrigation areas considering farmers' risk tolerance.

Water option trading could facilitate water conservation in irrigation areas to achieve optimal allocation of agricultural water resources. However, the risk associated with water-saving decisions increases due to the uncertainties of tradeable water and water-saving benefits, which makes farmers in the irrigation area with heterogeneous risk tolerances exhibit varied option water-saving willingness (OWSW) in response to the water option contract. Thus, this article provides a novel framework for prior assessing the OWSW in the irrigated area that considers farmers' heterogeneous risk tolerance and proposes the optimal contractual water demand to stimulate the OWSW.

Combined Application of Salinomycin and ATRA Induces Apoptosis and Differentiation of Acute Myeloid Leukemia Cells by Inhibiting WNT/β-Catenin Pathway.

Background And Objective: All-trans retinoic acid (ATRA) is only effective in acute promyelocytic leukemia (APL), but not in other subtype of acute myeloid leukemia (AML). Salinomycin targets tumor cells rather than non-tumorigenic cells, and WNT/β-catenin pathway inhibition is one of the mechanisms of its anti-tumor activity. There is a crosstalk between RA and WNT/β-catenin pathway.

Combination of midostaurin and ATRA exerts dose-dependent dual effects on acute myeloid leukemia cells with wild type FLT3.

Background: Midostaurin combined with chemotherapy is currently used to treat newly diagnosed acute myeloid leukemia (AML) patients with FMS-like tyrosine kinase 3 (FLT3)-mutations. However, midostaurin acts as an antagonist to some chemotherapeutic agents in leukemia cell lines without FLT3 mutations. All-trans retinoic acid (ATRA) induces apoptosis when used in combination with midostaurin in FLT3-mutated AML cells.

Damage Control Surgery for Severe Abdominal Sepsis With Free Skin Graft Transplantation: A Case Report.

Background: Acute abdomen represents a great surgical challenge. Damage control surgery has been a better approach in acute abdominal emergencies to reduce the risk of mortality compared with primary definitive surgery.

Case Presentation: A 52-year-old man presented with nonspecific abdominal pain for 2 days.

Antiferromagnetism Induced by Bond Su-Schrieffer-Heeger Electron-Phonon Coupling: A Quantum Monte Carlo Study.

Antiferromagnetism (AFM) such as Néel ordering is often closely related to Coulomb interactions such as Hubbard repulsion in two-dimensional (2D) systems. Whether Néel AFM ordering in two dimensions can be dominantly induced by electron-phonon couplings (EPC) has not been completely understood. Here, by employing numerically exact sign-problem-free quantum Monte Carlo (QMC) simulations, we show that bond Su-Schrieffer-Heeger (SSH) phonons with frequency ω and EPC constant λ can induce AFM ordering for a wide range of phonon frequency ω>ω_{c}.

Feasible Catalytic-Insoluble Strategy Enabled by Sulfurized Polyacrylonitrile with Built Electrocatalysts for Ultrastable Lithium-Sulfur Batteries.

To date, elemental sulfur has been considered as a prospective cathode material for exploring high-energy power systems with low cost and sustainability. However, its practical commercialization has been impeded by inherent drawbacks of notorious capacity decay, unsatisfied insulating nature, and sluggish conversion chemistry. To address these issues, for the first time, freestanding nanofibrous networks with hierarchical nanostructures are facilely constructed by inlaying electrocatalytic bimetallic chalcogenides (FeMnS nanoparticles) into conductive graphene nanosheet (GN)-doped sulfurized polyacrylonitrile (SPAN) fiber matrices.

Clinical significance of circulating tumour cells and tumour marker detection in the chemotherapeutic evaluation of advanced colorectal cancer.

Aim: Systemic chemotherapy combining biological targeted therapies is the standard therapy for patients with metastatic colorectal cancer (mCRC), but effective markers are needed to identify clinical responders. Circulating tumour cells (CTCs) have been associated with prognosis in patients with mCRC. This study aimed to explore the relationship between CTC number and the clinical response of patients with advanced CRC.

Trametinib enhances ATRA-induced differentiation in AML cells.

All-trans retinoic acid (ATRA) is only clinically useful in acute promyelocytic leukemia (APL), but not other subtypes of acute myeloid leukemia (AML). In the present study, a clinically achievable concentration of trametinib, a highly selective inhibitor of MEK, enhanced ATRA-induced differentiation in AML cell lines, HL-60 and U937 as well as AML primary cells. Moreover, trametinib-ATRA (tra-ATRA) co-treatment restored ATRA sensitivity in ATRA-resistant AML cell line, HL-60Res.

Rapid In Situ Polymerization of Polyacrylonitrile/Graphene Oxide Nanocomposites as Precursors for High-Strength Carbon Nanofibers.

Graphene oxide (GO) has been widely used as an additive of polyacrylonitrile (PAN)-based carbon nanofibers (CNFs) to optimize its crystal structure and improve the mechanical performances of nanofibers. However, the homogeneous dispersion of GO nanosheets among entangled PAN molecular chains is always challenging, and the poor dispersion of GO severely limits its positive effects on both the structure and performances of CNFs. Considering this issue, this paper provides for the first time an effective solution to achieve rapid and uniform introduction of GO in PAN-based nanofibers via in situ polymerization, and the optimization of the nanofiber structure by GO is systematically studied in three consecutive stages (polymerization, electrospinning, and carbonization) of the production process.

Characterizing the Structural Pattern of Heavy Smokers Using Multivoxel Pattern Analysis.

Smoking addiction is a major public health issue which causes a series of chronic diseases and mortalities worldwide. We aimed to explore the most discriminative gray matter regions between heavy smokers and healthy controls with a data-driven multivoxel pattern analysis technique, and to explore the methodological differences between multivoxel pattern analysis and voxel-based morphometry. Traditional voxel-based morphometry has continuously contributed to finding smoking addiction-related regions on structural magnetic resonance imaging.

Temperature measurement using a multi-wavelength fiber ring laser based on a hybrid gain medium and Sagnac interferometer.

In this paper, a multi-wavelength fiber ring laser (MWFRL) based on a hybrid gain medium and Sagnac interferometer (SI) used for temperature measurement has been proposed and experimentally demonstrated. Experiments have been carried out with polarization maintaining fibers (PMF) of different lengths, which are incorporated in the SI as sensing elements. Stable multi-wavelength oscillation at 1560 nm band is successfully achieved with the wavelength instability of ±0.

Using BI-RADS Stratifications as Auxiliary Information for Breast Masses Classification in Ultrasound Images.

Breast Ultrasound (BUS) imaging has been recognized as an essential imaging modality for breast masses classification in China. Current deep learning (DL) based solutions for BUS classification seek to feed ultrasound (US) images into deep convolutional neural networks (CNNs), to learn a hierarchical combination of features for discriminating malignant and benign masses. One existing problem in current DL-based BUS classification was the lack of spatial and channel-wise features weighting, which inevitably allow interference from redundant features and low sensitivity.

Electrochemical Insights, Developing Strategies, and Perspectives toward Advanced Potassium-Sulfur Batteries.

The boosting demand for high-capacity energy storage systems requires innovative battery technologies with low-cost and sustainability. The advancement of potassium-sulfur (K-S) batteries have been triggered recently due to abundant resource and cost effectiveness. However, the functional performance of K-S batteries is fundamentally restricted by the vague understanding of K-S electrochemistry and the imperfect cell components or architectures, facing the issues of low cathode conductivity, intermediate shuttle loss, poor anode stability, electrode volume fluctuation, etc.

B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis.

ProMyelocyticLeukemia (PML) protein can polymerize into a mega-Dalton nuclear assembly of 0.1-2 μm in diameter. The mechanism of PML nuclear body biogenesis remains elusive.

Combination of enzastaurin and ATRA exerts dose-dependent dual effects on ATRA-resistant acute promyelocytic leukemia cells.

All-trans retinoic acid (ATRA) resistance continues to be a critical problem in acute promyelocytic leukemia (APL)-relapsed patients. In this study, a clinically achievable concentration of enzastaurin synergized with ATRA to induce differentiation and apoptosis in ATRA-resistant APL cell lines, NB4-R1 and NB4-R2. Mechanistically, although enzastaurin is a protein kinase Cβ (PKCβ) inhibitor, PKCβ may not be required since the activity of PKCβ was not suppressed by enzastaurin-ATRA (enz-ATRA) co-treatment, and another PKCβ-selective inhibitor did not mimic the effects of enzastaurin.