Postextrasystolic repolarization changes of ventricular premature beats correlate with structural heart disease and suggest prognostic implications.

Ventricular premature beats (VPBs) can potentially lead to life-threatening arrhythmias, especially in patients with structural heart disease (SHD). However, identifying dangerous VPBs has always been a topic and challenge in clinical research. This study aimed to evaluate the relationship of postextrasystolic repolarization changes of VPBs with SHD and its possible additional prognostic value.

Correction of I in human induced pluripotent stem Cell-derived cardiomyocyte carrying DPP6 mutation in early repolarization syndrome by CRISPR/Cas9 genome editing.

Early repolarization syndrome (ERS) is defined as occurring in patients with early repolarization pattern who have survived idiopathic ventricular fibrillation with clinical evaluation unrevealing for other explanations. The pathophysiologic basis of the ERS is currently uncertain. The objective of the present study was to examine the electrophysiological mechanism of ERS utilizing induced pluripotent stem cells (iPSCs) and CRISPR/Cas9 genome editing.

A novel method for septal reduction therapy by three-dimensional guided transvenous intraseptal pulsed-field ablation.

Background: Pulsed-field ablation (PFA) is a nonthermal method for achieving selective cell death with little inflammation response. However, there are no reports of PFA for septal reduction therapy (SRT).

Objective: The purpose of this study was to investigate the effectiveness and safety of PFA for SRT.

Administration of macrolide antibiotics increases cardiovascular risk.

Background: The increased risk of cardiovascular events in patients prescribed macrolides has been subject to debate for decades.

Methods: Medline, EMBASE databases and ClinicalTrials.gov were searched from inception until August 31, 2022 for studies investigating the link between macrolides and cardiovascular risk.

Doping Regulation in Polyanionic Compounds for Advanced Sodium-Ion Batteries.

It has long been the goal to develop rechargeable batteries with low cost and long cycling life. Polyanionic compounds offer attractive advantages of robust frameworks, long-term stability, and cost-effectiveness, making them ideal candidates as electrode materials for grid-scale energy storage systems. In the past few years, various polyanionic electrodes have been synthesized and developed for sodium storage.

Segmentation of Spontaneous Intracerebral Hemorrhage on CT With a Region Growing Method Based on Watershed Preprocessing.

Intracerebral hemorrhage (ICH) poses a great threat to human life due to its high incidence and poor prognosis. Identification of the bleeding location and quantification of the volume based on CT images are of great significance for assisting the diagnosis and treatment of ICH. In this study, a region-growing algorithm based on watershed preprocessing (RG-WP) was proposed to segment and quantify the hemorrhage.

An electrographic AV optimization for the maximum integrative atrioventricular and ventricular resynchronization in CRT.

Background: Atrioventricular (AV) delay could affect AV and ventricular synchrony in cardiac resynchronization therapy (CRT). Strategies to optimize AV delay according to optimal AV synchrony (AV) or ventricular synchrony (AV) would potentially be discordant. This study aimed to explore a new AV delay optimization algorithm guided by electrograms to obtain the maximum integrative effects of AV and ventricular resynchronization (opt-AV).

An Integrative Investigation of Parabistichella variabilis (Protista, Ciliophora, Hypotrichia) Including Its General Morphology, Ultrastructure, Ontogenesis, and Molecular Phylogeny.

Hypotrichs are a highly differentiated and very diverse group of ciliated protists. Their systematics and taxonomy are challenging and call for detailed investigations on their general morphology, ultrastructure, ontogenesis, and molecular phylogeny. Here, a comprehensive study is conducted on a brackish water population of Parabistichella variabilis using light and electron microscopy and phylogenetic analyses based on small subunit ribosomal DNA sequence data.

Early repolarization pattern associated with coronary artery disease and increased the risk of cardiac death in acute myocardium infarction.

Background: Early repolarization pattern (ERP) was associated with sudden cardiac death in recent studies. However, the associations between ERP and coronary artery disease (CAD), and ERP and cardiac death caused by acute myocardial infarction (MI) remains unclear.

Methods: We retrospectively enrolled consecutive 1,545 CAD patients and 908 non-CAD subjects as control group which were confirmed by coronary angiograph.

A novel mutation in GPD1‑L associated with early repolarization syndrome via modulation of cardiomyocyte fast sodium currents.

Early repolarization syndrome (ERS) is associated with genetic mutations, but the role of the glycerol‑3‑phosphate dehydrogenase 1‑like (GPD1‑L) mutation remains unclear. The aim of the present study was to investigate the role and potential underlying mechanism of GPD1‑L mutation P112L in the pathogenesis of ERS. Whole‑genome sequencing was performed on samples from a family with ERS, and the gene sequencing results were analyzed using bioinformatics.

Interleukin-1 blockade treatment decreasing cardiovascular risk.

Background: Interleukin-1 (IL-1) played a role in the occurrence and development of atherosclerosis and cardiovascular events. However, the association between IL-1 blockage treatment and reducing of cardiovascular risk remains poorly defined.

Hypothesis: IL-1 blockage treatment reduce the risk and incidence rate of overall major adverse cardiovascular events (MACE), all-cause death, acute myocardial infarction(MI), unstable angina and heart failure.

Electrophysiological characteristics of the earliest activation site in idiopathic right ventricular outflow tract arrhythmias under mini-electrode mapping.

Introduction: Right ventricular outflow tract ventricular arrhythmias (RVOT VAs) often originate in the voltage-transitional zone. The target electrogram could be compromised by the architecture of the roving catheter. Mini-electrodes could improve the mapping resolution, especially in low-voltage areas.

A Heterozygous Missense hERG Mutation Associated with Early Repolarization Syndrome.

Background/aims: Early repolarization syndrome (ERS) has been recently recognized as early repolarization pattern with idiopathic ventricular fibrillation. However, the genetic background of ERS has not been fully understood.

Methods: A Chinese family with sudden cardiac death associated with ERS was investigated.

Mutation in KCNE1 associated to early repolarization syndrome by modulation of slowly activating delayed rectifier K current.

Background: Recent studies have revealed that mutation in KCNE1, β-subunits of cardiac potassium channel, involved in ventricular fibrillation. Whereas its role in early repolarization syndrome (ERS) is less well understood.

Objective: To study whether mutant in KCNE1 is associated with ERS and explore the possible underlying molecular mechanisms.

Taxonomic studies on Aegyria apoliva sp. nov. and Trithigmostoma cucullulus (Müller, 1786) Jankowski, 1967 (Ciliophora, Cyrtophoria) with phylogenetic analyses.

The morphology, including the ciliary pattern, of two cyrtophorid ciliates, namely Aegyria apoliva sp. nov. and Trithigmostoma cucullulus (Müller, 1786) Jankowski, 1967, were investigated.

Bacterial community structure and novel species of magnetotactic bacteria in sediments from a seamount in the Mariana volcanic arc.

Seamounts are undersea mountains rising abruptly from the sea floor and interacting dynamically with underwater currents. They represent unique biological habitats with various microbial community structures. Certain seamount bacteria form conspicuous extracellular iron oxide structures, including encrusted stalks, flattened bifurcating tubes, and filamentous sheaths.

The Role of Holter Monitoring in the Diagnosis of Early Repolarisation Pattern.

Background: A slower heart rate can exaggerate J-point elevation in a 12-lead ECG. This study examined the role of Holter monitoring in the diagnosis of early repolarisation pattern (ERP).

Methods: We examined 24-hour Holter recordings of 4000 consecutive patients seen at an outpatient clinic, and found 500 patients (12.