Publications by authors named "Xuling Guo"
Article Synopsis
- - SDF-1 is a CXC chemokine that attracts T-cells, and researchers studied its impact on tumor growth by inserting it into J558 myeloma cells, observing the resultant effects on tumor formation in mice.
- - Tumors expressing SDF-1 showed a significant regression and were infiltrated by immune T-cells (CD4(+) and CD8(+)), suggesting that SDF-1 plays a role in boosting the T-cell response against tumors.
- - The study indicates that SDF-1 can enhance immune responses when used in tumor cell vaccinations, leading to stronger protection against tumor challenges, highlighting its potential in cancer immunotherapy.
Aim: Dendritic cell-tumor cell fusion hybrid vaccines which facilitate antigen presentation represent a new powerful strategy in cancer immunotherapy. The clinical frequency of objective responses to the conventional fusion hybrid vaccines is still quite low, indicating that the current conventional protocol of simply fusing dendritic cells (DCs) and tumor cells needs further improvement to enhance its antitumor efficiency.
Methods: In the present study, we generated a novel fusion hybrid DC/J558(CD40L) by fusing DCs and an engineered J558(CD40L) myeloma cells expressing CD40 ligand (CD40L) molecule using polyethylene glycol (PEG).