Publications by authors named "Xulei Hu"
Background: Dravet syndrome (DS) is a severe epileptic encephalopathy mainly caused by haploinsufficiency of the gene , which encodes the voltage-gated sodium channel Na1. 1 in the brain. While mutations are known to be the primary cause of DS, other genes that may cause DS are poorly understood.
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- Spinal cord injury (SCI) can cause sensorimotor dysfunction and significantly affects metabolic activity in the brain, particularly in areas like the cortex and thalamus.
- A study involving adult rats compared acute and chronic treatment groups, finding that while overall metabolic concentrations were similar, the acute group showed significant changes in metabolic kinetics shortly after SCI.
- The research highlights the long-term effects of SCI on brain metabolism and suggests that understanding these changes could inform treatment strategies, such as mitochondrial transplantation, for enhancing recovery.