Heparin-Functionalized Bioactive Glass to Harvest Endogenous Growth Factors for Pulp Regeneration.

Pulp and periapical diseases can lead to the cessation of tooth development, resulting in compromised tooth structure and functions. Despite numerous efforts to induce pulp regeneration, effective strategies are still lacking. Growth factors (GFs) hold considerable promise in pulp regeneration due to their diverse cellular regulatory properties.

Long noncoding RNA regulates hepatic lipid metabolism by modulating lipogenesis and fatty acid oxidation.

Nonalcoholic fatty liver disease (NAFLD) is considered a major health epidemic with an estimated 32.4% worldwide prevalence. No drugs have yet been approved and therapeutic nodes remain a major unmet need.

Reinforcing Hydrogel by Nonsolvent-Quenching-Facilitated In Situ Nanofibrosis.

Nanofibrous hydrogels are pervasive in load-bearing soft tissues, which are believed to be key to their extraordinary mechanical properties. Enlighted by this phenomenon, a novel reinforcing strategy for polymeric hydrogels is proposed, where polymer segments in the hydrogels are induced to form nanofibers in situ by bolstering their controllable aggregation at the nanoscale level. Poly(vinyl alcohol) hydrogels are chosen to demonstrate the virtue of this strategy.

Silybin regulates P450s activity by attenuating endoplasmic reticulum stress in mouse nonalcoholic fatty liver disease.

Cytochrome P450s are important phase I metabolic enzymes located on endoplasmic reticulum (ER) involved in the metabolism of endogenous and exogenous substances. Our previous study showed that a hepatoprotective agent silybin restored CYP3A expression in mouse nonalcoholic fatty liver disease (NAFLD). In this study we investigated how silybin regulated P450s activity during NAFLD.

Bio-Compatible Ca-BDC/Polymer Monolithic Composites Templated from Bio-Active Ca-BDC Co-Stabilized CO-in-Water High Internal Phase Emulsions.

Because of the nontoxic solvents contained in CO-in-water emulsions, porous polymer composites templated from these emulsions are conducive for bio-applications. Herein, bio-active rod-like calcium-organic framworks (Ca-BDC MOFs, BDC= 1,4-benzenedicarboxylate anion) particles co-stabilized CO-in-water high internal phase emulsion (C/W HIPE) in the presence of polyvinyl alcohol (PVA) is first presented. After curing of the continuous phase, followed by releasing CO, integral 3D macro-porous Ca-BDC monolith and Ca-BDC/Poly(2-hydroxyethyl methacrylate--acrylamide) HIPEs monolithic composites [Ca-BDC/P(AM--HEMA)HIPEs] with open-cell macro-porous structures were successfully prepared.