Publications by authors named "Xujun Lu"
The prevailing design philosophy for polymeric vectors delivering siRNA is rooted in the post-transcriptional gene silencing (PTGS) mechanism. Yet, the transcriptional gene silencing (TGS) mechanism offers a potentially more durable silencing effect, which necessitates efficient siRNA delivery into the nucleus. However, it remains a challenge for the polymeric vectors to efficiently deliver siRNA into the nucleus.
View Article and Find Full Text PDFBackground: The occurrence of eczema is related to helper T 22 (Th22) cytokine disorder, and Th22 mainly secretes interleukin-22 (IL-22). This study aims to investigate the predictive value of umbilical cord blood IL-22 levels on the onset of eczema in infants within 42 days.
Study Design: The study selected 157 full-term healthy neonates born between September 2020 and May 2021.
Treatment of Erythrodermic Psoriasis in Children with Secukinumab: A Case Report.
Clin Cosmet Investig Dermatol
July 2023
Article Synopsis
- Erythrodermic psoriasis (EP) is a serious type of psoriasis, and common treatments for children can have severe side effects.
- A seven-year-old girl transitioned from another psoriasis type to EP and was successfully treated with secukinumab.
- After multiple injections, she achieved nearly complete skin clearance and showed no adverse reactions, suggesting secukinumab may be an effective treatment for children with EP.