Publications by authors named "Xujian Luo"

Eight novel Ir(III) complexes listed as [Ir(H-P)(P)]PF (), [Ir(H-P)(dMP)]PF (), [Ir(H-P)(MP)]PF (), [Ir(H-P)(tMP)]PF (r), [Ir(MPy)(P)]PF (), [Ir(MPy)(dMP)]PF (), [Ir(MPy)(MP)]PF (), [Ir(MPy)((tMP)]PF () with 2-phenylpyri-dine () and 3-methyl-2-phenylpyridine () as ancillary ligands and pyrido-[3,2-]-pyrido[1',2':1,2]imidazo[4,5-]phenazine (), 12,13-dimethyl pyrido-[3,2-]-pyrido[1',2':1,2]-imidazo-[4,5-]-phenazine (), 2-methylpyrido [3,2-]-pyrido-[1',2':1,2]-imidazo-[4,5-]-phenazine (), and 2,12,13-trimethylpyrido-[3,2-]-pyrido-[1',2':1,2]-imidazo-[4,5-]-phenazine () as main ligands, respectively, were designed and synthesized to fully characterize and explore the effect of their toxicity on cancer cells. Cytotoxic mechanism studies demonstrated that the eight Ir(III) complexes exhibited highly potent antitumor activity selectively against cancer cell lines NCI-H460, T-24, and HeLa, and no activity against HL-7702, a noncancerous cell line. Among the eight Ir(III) complexes, exhibited the highest cytotoxicity with an IC = 5.

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A graphene oxide-based method has been developed for ultrasensitive and selective determination of microRNA-141 by means of rolling circle amplification (RCA) and exonuclease III (Exo III)-assisted recycling amplification. The method uses (a) a padlock probe with a hybrid sequence that is complementary to the target microRNA-141 at both the 5'- and the 3'-end, and (b) a long binding region of a signalling reporter strand. On addition of microRNA-141, it acts as the primer for triggering the RCA reaction following ligation.

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A new copper(II) complex of dasatinib (DAS) was synthesized and characterized via ESI-MS, UV-Vis, IR, single-crystal X-ray diffraction analysis, H and C NMR spectroscopy, and elemental analysis. The composition of the new complex (1) was found to be [Cu(DAS + H)(NO)(HO)]NO·(HO)·(CHOH). Through MTT assay, it was found that 1 had high cytotoxicity towards A549, HeLa, BEL-7402, Hep-G2, NCI-H460, and MGC80-3 tumor cell lines, with IC values in 4.

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There iridium(III) complexes, [Ir(3-MeO-Phtpy)Cl] (1), [Ir(2-MeO-Phtpy)Cl] (2) and [Ir(4-MeO-Phtpy)Cl] (3) with 4'-(3-methoxyphenyl)-2,2':6',2″-terpyridine (3-MeO-Phtpy), 4'-(2-methoxyphenyl)-2,2':6',2″-terpyridine (2-MeO-Phtpy) and 4'-(4-methoxyphenyl)-2,2':6',2″-terpyridine (4-MeO-Phtpy) as ligands, respectively, were synthesized and evaluated for their antiproliferative activities. In these complexes, the iridium(III) center adopts a six-coordinate distorted octahedral geometry. Among them, complex 1 exhibited the most potent activity, with IC values of 3.

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Two G-quadruplex ligands [Pt(L(a))(DMSO)Cl] (Pt1) and [Pt(L(b))(DMSO)Cl] (Pt2) have been synthesized and fully characterized. The two complexes are more selective for SK-OV-3/DDP tumor cells versus normal cells (HL-7702). It was found that both Pt1 and Pt2 could be a telomerase inhibitor targeting G-quadruplex DNA.

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The title complex, [CoNa(CO5P)(H2O)5]n, was obtained by reacting sodium phosphono-formate with cobalt nitrate. The complex contains cobalt(II) and sodium ions, which are bridged by the O atoms of two aqua ligands. The Co(II) ion is octahedrally coordinated by three phosphonoformato ligands (one bi- and the other monodentate) and by two O atoms from the bridging aqua ligands.

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The reaction of 4-chloro-2-(quinolin-8-yl-imino-meth-yl)phenol (HClQP) with cobalt(II) dichloride hexa-hydrate in methanol/chloro-form under solvothermal conditions yielded the title compound, [Co(C16H10ClN2O)2][CoCl3(CH3OH)]. The Co(III) atom is six-coordinated in a slightly distorted octa-hedral geometry by four N atoms and two O atoms of two tridentate HClQP ligands, which are nearly perpendicular to each other, making a dihedral angle of 86.95°.

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Plumbagin and its Cu (II) complex [Cu (plumbagin)(2)]·H(2)O have been synthesized, and their antioxidant activities towards the inhibitory effect on DPPH free radical, reducing power, total antioxidant capacity, and inhibition on lipid peroxidation were investigated. Plumbagin and its Cu (II) complex were found to exhibit scavenging activities on DPPH radical with the inhibitory rate of 41% and 24%, respectively. The reducing power of plumbagin was outstanding at the concentrations of 1.

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The asymmeric unit of the title compound, [Co(C(10)H(9)N(4)O(2)S)(2)(C(5)H(5)N)(2)]·0.5H(2)O, contains the distorted octa-hedral trans-[Co(sdz)(2)(py)(2)] (sdz is the sulfadiazine anion and py is pyridine) complex mol-ecule and a half-mol-ecule of water, which lies on a twofold rotation axis. A three-dimensional network is generated by N-H⋯O and O-H⋯O hydrogen bonds between the complex and the water mol-ecules.

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