Associations between human cytomegalovirus infection and type 2 diabetes mellitus: a systematic review and meta-analysis.

Objective: Multiple studies have reported a potential contribution of human cytomegalovirus (HCMV) to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, the association between HCMV and type 2 diabetes mellitus (T2DM) remains unclear. In this paper, we employ the meta-analysis approach to investigate the potential correlation between HCMV infection and T2DM.

Genotype-phenotype associations in familial exudative vitreoretinopathy: A systematic review and meta-analysis on more than 3200 individuals.

Objective: To systematically review the relationship between genotypes and clinical phenotypes of Familial exudative vitreoretinopathy (FEVR) to support risk estimation and therapeutic decisions.

Design: Systematic review with meta-analysis.

Data Sources: The data of our study were collected from PubMed, Embase, Web of Science, Cochrane, CBM, China National Knowledge Infrastructure (CNKI), WAN FANG and VIP databases since inception to August 2021.

Identifying diabetes from conjunctival images using a novel hierarchical multi-task network.

Diabetes can cause microvessel impairment. However, these conjunctival pathological changes are not easily recognized, limiting their potential as independent diagnostic indicators. Therefore, we designed a deep learning model to explore the relationship between conjunctival features and diabetes, and to advance automated identification of diabetes through conjunctival images.

Reduced expression of the lncRNA NRON is a potential hallmark of the CMV-amplified CD8+ T cell accumulations commonly seen in older humans.

The characteristic accumulation of late-stage differentiated CD8+ T cells is enhanced by lifelong latent cytomegalovirus (CMV) persistence, which makes it challenging to screen for subclinical biomarkers of immune aging in the elderly. We systematically identified predominantly preformed, long, noncoding RNAs (lncRNAs) as integrative biomarkers of CD8 T cell aging in 14 elderly CMV carriers over 80 years of age. After sorting the CD28CD8 T cell subset and its CD28CD8 counterpart in five nonagenarians, we profiled the differential expression of lncRNAs and genes in CD28CD8 T cells via array detection.

Comprehensive circular RNA profiling reveals that circular RNA100783 is involved in chronic CD28-associated CD8(+)T cell ageing.

Background: Ageing brings about the gradual deterioration of the immune system, also known as immunosenescence. The role of non-coding circular RNA in immunosenescence is under studied. Using circular RNA microarray data, we assembled Comparison groups (C1, C2, C3 and C4) that allowed us to compare the circular RNA expression profiles between CD28(+)CD8(+) T cells and CD28(-)CD8(+) T cells isolated from healthy elderly or adult control subjects.

Sensitive birefringent temperature sensor based on a waveguide ring resonator.

A sensitive birefringent thermometer based on a SiO2 waveguide ring resonator is demonstrated in this paper. It can be used to fabricate a terahertz thermal detector. The temperature sensitivity is enhanced by the resonances of two polarization modes in the waveguide ring resonator.

Closed-loop resonant fiber optic gyro with an improved digital serrodyne modulation.

To widen the linear dynamic range and improve the linearity, a closed-loop resonant fiber optic gyro (RFOG) is proposed and experimentally demonstrated. To overcome the effect of the imperfect serrodyne modulation, an improved frequency shifting module is designed and constructed on a LiNbO3 phase modulator. Its frequency resolution is improved to 0.

Evaluation of crowded optic nerve head and small scleral canal in intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage.

Background: Intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage (IHAPSH) is a clinical syndrome most commonly affecting myopic eyes with tilted discs that usually resolves spontaneously without treatment. Subretinal hemorrhage usually occurs peripapillary on the nasally adjacent side near the optic disc. The etiology of this condition is still unknown.

Improving thermal stability of a resonator fiber optic gyro employing a polarizing resonator.

To improve the thermal stability of a resonator fiber optic gyro (R-FOG), a transmission-type polarizing resonator by inserting two in-line polarizers in a polarization-maintaining fiber resonator with twin 90° polarization-axis rotated splices is proposed and experimentally demonstrated. The in-line polarizers attenuate the unwanted resonance by introducing high loss for the unwanted eigenstates of polarization in the resonator. The desired resonance in the resonator can keep excellent stability in a wide temperature range, thus the temperature-related polarization error in the R-FOG is dramatically suppressed.

Reduction of polarization-fluctuation induced drift in resonator fiber optic gyro by a resonator integrating in-line polarizers.

A method to decrease the polarization-fluctuation induced drift in a resonator fiber optic gyro (R-FOG) is demonstrated by inserting two in-line polarizers in a polarization-maintaining fiber resonator with twin 90° polarization-axis rotated splices. The in-line polarizers attenuate the unwanted resonance by introducing high loss for the unwanted eigenstates of polarization in the resonator. Compared to the resonator without in-line polarizers, the polarization-fluctuation induced drift is reduced by 6×10(3) times.

Polarization-induced noise in resonator fiber optic gyro.

An optical fiber ring resonator (OFRR) is the key rotation-sensing element in the resonator fiber optic gyro (R-FOG). In comparing between different OFRR types, a simulation model that can apply to all cases is set up. Both the polarization crosstalk and polarization-dependent loss in the coupler are fully investigated for the first time to our knowledge.

Full investigation of the resonant frequency servo loop for resonator fiber-optic gyro.

Resonator fiber-optic gyro (RFOG) is a high-accuracy inertial rotation sensor based on the Sagnac effect. A high-accuracy resonant frequency servo loop is indispensable for a high-performance RFOG. It is composed of a frequency discriminator, a loop filter, and a laser actuator.

Resonator fiber optic gyro employing a semiconductor laser.

Resonator fiber optic gyro (RFOG) based on the Sagnac effect has the potential to achieve the inertial navigation system requirement with a short sensing coil. Semiconductor laser is one of the key elements for integration and miniaturization of the RFOG. In this paper, an RFOG employing a semiconductor laser is demonstrated.

[Clinical characteristics and pathogenesis of intracapillary hemorrhage with adjacent peripapillary subretinal hemorrhage].

Objective: To study the clinical characteristics and pathogenesis of intracapillary hemorrhage with adjacent peripapillary subretinal hemorrhage (IHAPSH).

Methods: A retrospective review of 8 patients with IHAPSH. The demographical data of the patients, the symptoms, initial and final visual acuities, biomicroscopic findings, fundus photographs, and the results of various special examinations, including fluoresce in angiography, B-scan ultrasonography, optical coherence tomography (OCT) and CT were analyzed.

[Prevention of posterior capsule opacification by combination of arsenic trioxide and perfect capsule].

Objective: Despite recent improvements in IOL design, posterior capsule opacification (PCO) remains a significant clinical problem after cataract surgery. The Perfect Capsule device (Milvella, Ltd., Epping, Australia) permits the introduction and subsequent removal of potentially toxic agents into the closed capsular bag.

[Prevalence of diabetic retinopathy among the elderly in rural southern Shuangcheng city, Heilongjiang province].

Objective: The purpose of this study was to understand the awareness, prevalence of diabetic retinopathy and treatment status of people aged over 50 and living in the rural areas of Shuangcheng city, Heilongjiang province, China.

Methods: Cluster sampling was used in randomly selected 5504 survey for ophthalmic clinical examination, in patients with diabetic retinopathy. A questionnaire in the state of knowledge about prevention and treatment was developed.

Pharmacokinetic study of mangiferin in rat plasma and retina using high-performance liquid chromatography.

Purpose: Although the naturally occurring antioxidant mangiferin has been widely used, it is not yet known whether it can cross the blood-retina barrier (BRB) and enter the eye. The purpose of this experiment was to investigate the ability of mangiferin to pass the blood-retina barrier.

Methods: Sprague-Dawley rats were used for biologic fluid sampling after intravenous administration of mangiferin at doses of 10, 25, and 50 mg/kg.

Determination of mangiferin in rat eyes and pharmacokinetic study in plasma after oral administration of mangiferin-hydroxypropyl-beta-cyclodextrin inclusion.

Purpose: To determine whether mangiferin can enter the eye, because the eye possesses the unique blood-ocular barrier.

Methods: Due to the low solubility of mangiferin, hydroxypropyl-beta-cyclodextrin was applied to improve the absorbance. A reversed-phase high-performance liquid chromatography assay for mangiferin in rat plasma and eye fluid was developed.

Time-dependent reduction of glutamine synthetase in retina of diabetic rats.

Diabetic Retinopathy (DR) is one of the most common complications of diabetes and a major cause of blindness worldwide. We studied the transcriptome of the diabetic retina using Series Analysis of Gene Expression (SAGE) technology and observed a 45.6% reduction in transcript levels of glutamine synthetase (GS) in streptozotocin-induced diabetic rats compared with normal rats.

[Mechanism of arsenic trioxide induced apoptosis in cultured human lens epithelium cells].

Objective: To study cytotoxic effects of arsenic trioxide (As2O3) on the human lens epithelium cells and to identify the biological mechanism for these effects.

Methods: In this experimental study, human lens epithelium cells (FHL124 cells) were cultured in Eagle's minimum essential medium supplemented with 5% fetal calf serum. The effects of As2O3 on FHL124 cells growth were tested by MTT, and apoptosis was detected by TUNEL assay.