Resveratrol alleviates heart failure by activating foxo3a to counteract oxidative stress and apoptosis.

Resveratrol has been extensively studied for its multifaceted health benefits. Nonetheless, the pharmacological mechanisms of resveratrol for heart failure remain elusive, especially the cardioprotective effects. To address this knowledge gap, we performed high-throughput drug screening using zebrafish and discovered that resveratrol significantly alleviated heart failure, including rescuing abnormalities in heart rate, blood flow, cardiac output, and nppb overexpression.

Life cycle assessment of an efficient biomass power plant supported by semi-closed supercritical CO cycle and chemical looping air separation.

Biomass power plant with carbon capture facility has great carbon emission reduction potential due to biomass's carbon neutrality characteristic, but it has been long-time suffered from undesirable system efficiency. This paper explored the life cycle carbon emission of a high-efficient biomass power generation system, which was comprised by the semi-closed supercritical CO cycle and chemical looping air separation sub-units. This system was proved to be environmentally superior with the life cycle warming impact value at 97.

A novel electrochemical sensor for glucose detection based on a TiCT /ZIF-67 nanocomposite.

A TiCT /ZIF-67 nanocomposite with outstanding conductivity has been prepared by loading ZIF-67 onto a two-dimensional TiCT nanosheet. TiCT sheets were synthesized by etching TiAlC, and then ZIF-67 was grown on the TiCT nanosheet. The TiCT /ZIF-67 nanocomposite exhibits excellent detection performance for glucose, with a low LOD of 3.

Consumer Cognition Analysis of Food Additives Based on Internet Public Opinion in China.

Food additives play an important role in the food supply, and it has been a food safety topic of great concern to the public. There has been no systematic research on Chinese consumers' concerns, attitudes, feelings, or opinions on supervision and media coverage of food additives in the past decade, which is an area worth exploring. This study was carried out to deeply understand consumers' cognition of food additives and formulate food safety risk communication strategies of food additives in China.

A novel electrochemical sensor for glyphosate detection based on TiCT /Cu-BTC nanocomposite.

The copper benzene-1,3,5-tricarboxylate (Cu-BTC) with outstanding chemical and physical properties, is a novel and promising material in the field of electrochemical sensing. However, it has significant limitations for direct application in electrochemical sensing due to the relatively weak conductivity of Cu-BTC. Here, the conductivity of Cu-BTC was improved by loading Cu-BTC onto two-dimensional TiCT nanosheets with high conductivity.

Precise Dose of Folic Acid Supplementation Is Essential for Embryonic Heart Development in Zebrafish.

Folic acid, one of the 13 essential vitamins, plays an important role in cardiovascular development. Mutations in folic acid synthesis gene 5,10-methylenetetrahydrofolate reductase () is associated with the occurrence of congenital heart disease. However, the mechanisms underlying the regulation of cardiac development by gene are poorly understood.

LPS enhances TLR4 expression and IFN‑γ production via the TLR4/IRAK/NF‑κB signaling pathway in rat pulmonary arterial smooth muscle cells.

The aim of the present study was to investigate the role of the Toll‑like receptor (TLR)4 signaling pathway in cellular response to lipopolysaccharide (LPS) in rat pulmonary artery smooth muscle cells (PASMCs). Chronic obstructive pulmonary disease (COPD) rats were established with passive inhaling cigarette smoke plus injection of LPS. The TLR4 protein in lung tissues was determined with immunohistochemical staining and protein levels of the components of the TLR4 pathway in PASMCs were analyzed with western blotting.