Erratum: Author correction to "Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning" [Acta Pharm Sin B 12 (2022) 2429-2442].

[This corrects the article DOI: 10.1016/j.apsb.

Effects of human umbilical cord mesenchymal stem cell-derived exosomes in the rat osteoarthritis models.

Mesenchymal stem cells (MSCs) offer great potential for treatment of osteoarthritis (OA) by promoting articular cartilage regeneration via paracrine secretion of exosomes; however, the underlying mechanisms are not fully understood. This study aimed to explore the therapeutic effects of exosomes secreted by human umbilical cord-derived MSCs (hUC-MSCs) in rat models of OA and reveal the underlying mechanisms. UC-MSCs and UC-MSC-exosomes were prepared and identified by transmission electron microscopy and flow cytometry.

Deuteration-Driven Photopharmacology: Deuterium-Labeled for Controlling Alpha 7 Nicotinic Acetylcholine Receptors.

Photopharmacology is a powerful approach to investigate biological processes and overcomes the common therapeutic challenges in drug development. Enhancing the photopharmacology properties of photoswitches contributes to extend their applications. Deuteration, a tiny structural modification, makes it possible to improve the photopharmacology and photophysical properties of prototype compounds, avoiding extra complex chemical changes or constructing multicomponent systems.

Pb isotopic fingerprinting of uranium pollution: New insight on uranium transport in stream-river sediments.

Uranium mill tailings (UMT) present a significant environmental concern due to high levels of radioactive and toxic elements, including uranium (U), thorium (Th), and lead (Pb), which can pose serious health risks to aquatic ecosystems. While Pb isotopic tracers have been widely utilized in environmental studies to identify elemental sources and geological processes, their application in U geochemistry remains relatively limited. In this study, we investigate the distribution and migration of U in stream-river sediments surrounding a decommissioned U hydrometallurgical area, employing Pb isotopes as tracers.

A randomized controlled trial to compare short-term outcomes following infragastric and infracolic omentectomy at the time of primary debulking surgery for epithelial ovarian cancer with normal-appearing omentum.

Background: Omentectomy is an important procedure in surgery for epithelial ovarian cancer, but the scope of omentectomy is not recommended in the guidelines. This study was performed to evaluate the benefits and risks of infragastric omentectomy in patients with epithelial ovarian cancer.

Methods: This trial is a single center prospective study.

Immunological role and clinical prognostic significance of P2RY6 in lung adenocarcinoma: a multi-omics studies and single-cell sequencing analysis.

Background: There is increasing evidence that recombinant human P2Y purinoceptor 6 (P2RY6) may be involved in inflammatory responses. However, the role of P2RY6 in lung adenocarcinoma (LUAD) remains unknown.

Methods: We used transcriptomic, genomic, single-cell transcriptomic, and methylation sequencing data from The Cancer Genome Atlas database to analyze the aberrant status and prognostic value of P2RY6 in a variety of tumors.

Reservoirs as high-efficacy sentinels of regional atmospheric pollution and precipitation: magnetic and chemical evidence from a typical subtropical reservoir in South China.

While there is a general sense that reservoirs can act as sentinels of climate change, their efficacy has not been thoroughly analyzed. Here multiple-proxy analyses including Pb, grain size, heavy metals, magnetic parameters, and spheroidal carbonaceous particles (SCPs) were conducted for a sediment core from a typical subtropical reservoir in South China (Huangkeng Reservoir). Pb dating revealed that the core spans from ~ 1964 to 2019, with the sedimentary rate increasing during recent years.

Efficacy evaluation of chimeric antigen receptor-modified human peritoneal macrophages in the treatment of gastric cancer.

Background: Gastric cancer is one of the most common cancers. Peritoneal carcinomatosis (PC) appears to be the most common pattern of recurrence, and more than half of the GC patients eventually die from PC. Novel strategies for the management of patients with PC are urgently needed.

A Vascular Centered Surgical Approach to Radical Hysterectomy: Laparoscopic Anatomy of Pelvic Vascular System Revisited.

Objective: As a standard therapy for locally invasive cervical cancer, radical hysterectomy (RH) has been in routine medical practice for more than a century [1]. However, challenges still exist due to the troublesome bleeding during parametrium dissection and resection, which could increase the risk of surgical complications and may probably affect surgical outcomes ultimately [2]. This video illustrated the three-dimensional anatomy of the pelvic vascular system with particular emphasis on "deep uterine vein" and further introduced a vascular-centered surgical approach to performing RH, which could facilitate parametrium dissection with less blood loss and obtain enough resection margins.

Targeting CD44 Variant 5 with an Antibody-Drug Conjugate Is an Effective Therapeutic Strategy for Intrahepatic Cholangiocarcinoma.

Unlabelled: Intrahepatic cholangiocarcinoma (ICC) is the second most frequent type of primary liver cancer. ICC is among the deadliest malignancies, highlighting that novel treatments are urgently needed. Studies have shown that CD44 variant isoforms, rather than the CD44 standard isoform, are selectively expressed in ICC cells, providing an opportunity for the development of an antibody-drug conjugate (ADC)-based targeted therapeutic strategy.

Human development at the cost of the environment?-an application of planetary pressures-adjusted human development index in the lens of planetary boundaries.

The human development index (HDI) was an important step toward a more human-oriented assessment of socioeconomic prosperity. Nevertheless, at the onset of the anthropocene, the environmental pillar of sustainable development is indispensable. This work aims to understand this conundrum of human development and its environmental cost or pressure through the use of the planetary pressures-adjusted human development index (PHDI) as well as introduce another modified version, planetary pressures, and inequality-adjusted human development index (PIHDI).

An Equality-Based Approach to Analysing the Global Food System's Fair Share, Overshoot, and Responsibility for Exceeding the Climate Change Planetary Boundary.

The climate catastrophe is being caused by human effects on earth system processes that are surpassing several planetary boundaries. This crisis is driven significantly by the global food system. It has been increasing over recent years, yet food systems are essential in upholding food and nutrition security.

Artificial intelligence-based preoperative prediction system for diagnosis and prognosis in epithelial ovarian cancer: A multicenter study.

Background: Ovarian cancer (OC) is the most lethal gynecological malignancy, with limited early screening methods and poor prognosis. Artificial intelligence technology has made a great breakthrough in cancer diagnosis.

Purpose: We aim to develop a specific interpretable machine learning (ML) prediction model for the diagnosis and prognosis of epithelial ovarian cancer (EOC) based on a variety of biomarkers.

Plant Macrofossils Reveal Aquatic Macrophyte Successions of a Typical Shallow Lake (Huanggai Lake, China) in the Past Century.

Aquatic macrophytes are one of the important biotic components of shallow lake ecosystems. Understanding the long-term evolution of the macrophyte community is crucial for lake management. Huanggai Lake, a typical shallow lake in the middle reach of the Yangtze River, was selected as the research site for this study.

Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning.

Head and neck squamous cell carcinoma (HNSCC) is one of the most common human cancers; however, its outcome of pharmacotherapy is always very limited. Herein, we performed a batch query in the connectivity map (cMap) based on bioinformatics, queried out 35 compounds with therapeutic potential, and screened out parbendazole as a most promising compound, which had an excellent inhibitory effect on the proliferation of HNSCC cell lines. In addition, tubulin was identified as a primary target of parbendazole, and the direct binding between them was further verified.

An Integrative Analysis Identifying RAB40C as an Oncogenic Immune Protein and Prognostic Marker of Lung Squamous Cell Carcinoma.

Background: RAB40C, a member of the Ras oncogene family, is a protein with GTPase and GTP-binding activity and is also predicted to be important in immunomodulation. However, the link between RAB40C and lung squamous cell carcinoma (LUSC) has not yet been elucidated. Exploring the relationship between RAB40C and LUSC could help expand the repertoire of immunotherapeutic targets for LUSC and provide more effective therapeutic options for LUSC patients, which behalf of our aim for our study.

Design, synthesis and biological evaluation of new parbendazole derivatives for the treatment of HNSCC.

Head and neck squamous cell carcinoma (HNSCC) is a lethal disease with a terrible prognosis, accounting for more than 900,000 new cases and 500,000 deaths each year, nevertheless, its pharmacotherapy is rather limited. Parbendazole was previously identified as a potential HNSCC therapy candidate in our research. Herein, we report the discovery of two series of parbendazole derivatives as tubulin inhibitors.

Ecological regime shifts reduced burial ability of aromatic hydrocarbons by both inland and coastal waters but driven by various nutrients.

Huge synthetic chemicals and hydrocarbons have been released to inland waters and oceans, composing anthropogenic dissolved organic carbon (ADOC). They complement a large budget for CO. Burial by inland and coastal marine sediments is crucial to reduce this budget.

Geochemical baseline establishment and pollution assessment of heavy metals in the largest coastal lagoon (Pinqing Lagoon) in China mainland.

Establishing geochemical baselines and assessment of heavy metal pollution in lagoon sediments are critical for providing guidance to coastal zone environmental management. We analyzed heavy metals in high-resolution sediment cores from Pinqing Lagoon in South China, and defined the baselines of common pollution elements with a significant anthropogenic contribution. With these baselines, a spatiotemporal pollution assessment revealed Cu and Cd as the predominant pollution metals in both core and surface sediments, although the ecological risk level in the interior lagoon remained low during the past ~170 years.

Understanding the relationship between globalization and biophysical resource consumption within safe operating limits for major Belt and Road Initiative countries.

Over the past few years, a growing number of scholars have explored environmental deterioration and its connection to various indicators acting as proxies for growth and globalisation. Taking this into view, the current study examines the globalisation-environment nexus, using 66 major countries and administrative regions of the Belt and Road Initiative (BRI) as case studies for 2000-2015. For this analysis, six biophysical resource usages were used within the safe operating space of the planetary boundary concept as proxies for the environmental state, along with the four main and five sub-indices of the Konjunkturforschungsstelle (KOF) globalisation index.

Discovery of small-molecule fluorescent probes for C-Met.

C-mesenchymal-epithelia transition factor (c-Met) is highly expressed in various solid tumors such as gastric cancer, liver cancer, and lung cancer, playing a pivotal role in the growth, maintenance, and development of different tumor cells. In this study, three small-molecule fluorescent probes (5, 11, 16) targeting c-Met were developed, and their design strategies were also initially explored. In general, the fluorescence properties of the probes themselves could meet the imaging requirements, and they have shown sufficient inhibitory activities against c-Met, especially probe 16, reflecting the targeting and acceptance.

High-resolution reconstruction of typhoon events since ~1850 CE based on multi-proxy sediment records in a coastal lagoon, South China.

Coastal lagoon sediments provide continuous and high-resolution records of the activity of past typhoons. In this study, multiple proxies were analyzed with a core taken from Pinqing Lagoon located on the northeast margin of the South China Sea. Based on Pb dating, grain sizes and other geophysical/geochemical analyses, a total of seven typhoon-induced layers covering the past ~170 years were identified and compared with observational and historical records of typhoons.