Publications by authors named "Xuhua Tan"

Purpose: To explore the potential of crystalline lens decentration and tilt as indicators for screening cataract patients for presbyopia-correcting intraocular lens (IOL) implantation.

Methods: Prospective observational study. Patients undergoing phacoemulsification with bifocal (Tecnis ZMB00) or extended depth-of-focus (EDOF) (Tecnis ZXR00) IOL implantation were consecutively enrolled.

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Purpose: To evaluate the predictive accuracy of 11 intraocular lens (IOL) calculation formulas in eyes with an axial length (AL) less than 22.00 mm.

Methods: New-generation formulas (Barrett Universal II [BUII], Emmetropia Verifying Optical [EVO] 2.

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Article Synopsis
  • The study aimed to assess how the back-to-front corneal radius ratio (B/F ratio) and posterior keratometry (PK) influence the accuracy of intraocular lens power calculations in patients who had myopic LASIK or PRK surgery.
  • Researchers analyzed data from 101 patients with cataracts after these procedures, measuring prediction errors and accuracy using various formulas.
  • The results showed that the Barrett True-K formula was the most accurate overall, while the Potvin-Hill formula was better for patients with low B/F ratios and flat PK.
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Importance: Capsular tension rings (CTRs) can support weak zonules and inhibit capsular shrinkage, thus potentially reducing intraocular lens (IOL) decentration and tilt. However, it has been debated whether CTRs can reduce IOL decentration and tilt in highly myopic eyes and whether CTR implantation is necessary for all highly myopic eyes.

Objective: To evaluate the influence of CTR implantation on IOL decentration and tilt in highly myopic eyes.

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Article Synopsis
  • The study aimed to explore the relationship between effective lens position (ELP) and patient factors in cataract patients, especially those with a history of pars plana vitrectomy (PPV), and to create a new formula for IOL calculation.
  • It included a comparison of ELP between two groups: 2793 age-related cataract patients and 915 post-PPV patients, evaluating how various patient characteristics impacted ELP using regression analysis.
  • The newly developed LISA-PPV formula was found to have the lowest prediction error compared to existing formulas, demonstrating its effectiveness for calculating IOL power in patients who have undergone PPV.
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Purpose: To investigate the between-eye differences of the crystalline lens in subjects with unilateral high myopia and assess its contribution to the interocular refractive error disparity.

Methods: Children and adolescents with unilateral high myopia, defined as cycloplegic spherical equivalent (SE) ≤ -5D in one eye and ≥ -3D in the other eye, were recruited. Ocular biometric parameters, including axial length (AL) and lens thickness (LT), were measured by IOLMaster 700.

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Purpose: To evaluate the performance of intraocular lens (IOL) calculation formulas and the effect of anterior chamber depth (ACD), axial length (AL) and lens thickness (LT) on the prediction accuracy in shallow ACD eyes.

Methods: This retrospective, consecutive case-series study included 648 eyes of 648 patients with an ACD < 3.0 mm who underwent phacoemulsification and IOL implantation.

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Purpose: To determine whether correcting the axial length (AL) measurement error of the IOLMaster 700 could improve the refractive prediction accuracy in silicone oil-filled eyes.

Methods: This study included 265 cataract patients (265 eyes) with silicone oil tamponade who were scheduled for phacoemulsification with intraocular lens (IOL) implantation. The performances of various formulas, including Barrett Universal II, Emmetropia Verifying Optical, Hoffer-QST, Kane, Ladas Super Formula, Pearl-DGS, Radial Basis Function and traditional formulas (Haigis, Hoffer Q, Holladay 1 and SRK/T), were evaluated.

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Purpose: To investigate the effect of posterior keratometry (PK) on the accuracy of 10 intraocular lens (IOL) power calculation formulas using standard keratometry (K) and total keratometry (TK).

Methods: This is a retrospective consecutive case-series study. The IOL power was calculated using K and TK measured by IOLMaster 700 in 6 new-generation formulas (Barrett Universal II, Emmetropia Verifying Optical (EVO) 2.

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Purpose: The underlying mechanism of congenital cataracts caused by deficiency or mutation of junctional adhesion molecule C (JAM-C) gene remains unclear. Our study aims to elucidate the abnormal developmental process in Jamc-/- lenses and reveal the genes related to lens development that JAM-C may regulate.

Methods: Jamc knockout (Jamc-/-) mouse embryos and pups were generated for in vivo studies.

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Purpose: To investigate the proportion of patients with predicted refractive astigmatism (PRA) of 0.75 diopters (D) or greater and associated risk factors among cataract surgery candidates with low corneal astigmatism.

Methods: A retrospective cross-sectional study was conducted in Zhongshan Ophthalmic Center, Guangzhou, China.

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Purpose: To identify risk factors of ocular anterior segment measurement error by the IOLMaster 700 in eyes implanted with an implantable Collamer lens (ICL).

Methods: In total, 152 patients with clear lens (152 eyes, group 1) and another 32 cataract patients (57 eyes, group 2) who underwent ICL implantation were included, and the presence of measurement error by the IOLMaster 700 was determined based on B-scan images. The risk factors for measurement error were evaluated by logistic regression, and the optimal threshold was determined using receiver operating characteristic analysis.

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Purpose: To investigate the effect of different myopia severity on the health-related quality of life (QOL) in both children and their parents.

Methods: Cross-sectional study from October to November, 2021. Age and sex-matched children with binocular emmetropia (-0.

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Purpose: Visual impairment from cataracts is closely associated with low income, but trial evidence regarding the impact of surgery on income is lacking. We investigated whether cataract surgery could increase personal income.

Design: A 2-arm, parallel-group, open-label, randomized controlled trial (ClinicalTrials.

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Purpose: To determine the optimal intraocular lens (IOL) calculation formula for vitrectomized eyes with diverse surgical and biometric characteristics.

Setting: Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Design: Retrospective consecutive case series study.

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Purpose: The purpose of this study was to compare total keratometry (TK) and posterior keratometry (PK) obtained by two swept-source optical biometers (IOLMaster 700 and CASIA2) and one Scheimpflug-based topography (Pentacam AXL).

Methods: The TK and PK in cataract surgery candidates obtained by IOLMaster 700, CASIA2, and Pentacam AXL were compared. Intraclass correlation coefficients (ICCs), limit of agreement, and Bland-Altman plots were used to assess the agreement.

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Purpose: To explore the risk factors and construct nomogram models to predict the risks of clinically significant intraocular lens (IOL) tilt and decentration after cataract surgery in patients with age-related cataract.

Setting: Zhongshan Ophthalmic Center, Guangzhou, China.

Design: Prospective cohort study.

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Purpose: To investigate the association between exogenous hormone use and the risk of cataract surgery among working-aged Australian women.

Methods: A total of 91 760 female participants aged 45-65 years and without prior history of cataract surgery were prospectively enrolled between January 2006 and December 2009 in New South Wales (NSW), Australia. A baseline self-reported questionnaire was used to collect information on participant demographic, socio-economic, lifestyle characteristics, medical history as well as the use of hormonal contraception and hormone replacement therapy (HRT).

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Purpose: The malfunction of junctional adhesion molecule C (JAM-C) has been reported to induce congenital cataract in humans and mice; however, specific characters and the mechanism of this cataract are still unclear. This study aimed to characterize abnormal lens development in Jamc knockout mice and clarify the underlying mechanism.

Methods: Jamc knockout mice backcrossed onto the C57BL/6 genetic background were used for this research.

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Purpose: To compare axial length (AL) measurements in silicone oil (SO)-filled eyes using swept-source optical coherence tomography (SS-OCT) (the IOLMaster 700 and OA2000) and partial coherence interferometry (the IOLMaster 500).

Setting: Zhongshan Ophthalmic Center, Guangzhou, China.

Design: Cross-sectional study.

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Purpose: To identify predictors and develop a prognostic nomogram for clinically significant intraocular lens (IOL) tilt and decentration in vitrectomized eyes.

Setting: Zhongshan ophthalmic center, Guangzhou, China.

Design: Prospective observational study.

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Purpose: To investigate the association between outdoor time and the risk of cataract surgery in a large Australian population.

Methods: This was a population-based prospective cohort study with 137,133 participants 45 to 65 years of age and without prior history of cataract surgery from the 45 and Up Study. Outdoor hours per day on weekdays and weekends, as well as tanning with repeated sun exposure, were assessed by a self-administered baseline questionnaire.

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Background/aims: Quantity of cataract surgery has long been an important public health indicator to assess health accessibility, however the quality of care has been less investigated. We aimed to summarise the up-to-date evidences to assess the real-world visual outcomes after cataract surgery in different settings.

Methods: A systematic review was undertaken in October 2021.

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Background And Aim: To assess the reproducibility of the novel ultrasound biomicroscopy, Insight 100 and its agreement with a swept-source optical coherence tomography, CASIA2.

Methods: A total of 96 volunteers (96 eyes) were enrolled. The radius of anterior lens curvature (RAL), the radius of posterior lens curvature (RPL), lens thickness (LT), and lens diameter (LD) were measured with Insight 100 and CASIA2.

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