Application of dose-gradient function in reducing radiation induced lung injury in breast cancer radiotherapy.

Objective: Try to create a dose gradient function (DGF) and test its effectiveness in reducing radiation induced lung injury in breast cancer radiotherapy.

Materials And Methods: Radiotherapy plans of 30 patients after breast-conserving surgery were included in the study. The dose gradient function was defined as DGH=VDVp3, then the area under the DGF curve of each plan was calculated in rectangular coordinate system, and the minimum area was used as the trigger factor, and other plans were triggered to optimize for area reduction.

Green transformational leadership and employee organizational citizenship behavior for the environment in the manufacturing industry: A social information processing perspective.

The employee organizational citizenship behavior for the environment (OCBE) contributes to the improvement of the organization's environment, its study is increasing in number. However, the psychological mechanism of promoting employee OCBE is still a missing link. Drawing on the theory of social information processing, this study seeks to establish the impact of green transformational leadership on employee OCBE and the mediating role of green organizational climate in this nexus.

The effect of core self-evaluations on career adaptability: The mediating role of protean career attitudes and the moderating role of meritocratic beliefs.

Based on the career construction model of adaptation, this study explores the impact of core self-evaluations on career adaptability, with the mediating role of protean career attitudes and moderating role of meritocratic beliefs. The results of the questionnaire survey on 1000 Chinese college students show that: (1) core self-evaluations positively predicted college students' career adaptability; (2) protean career attitudes mediated the relationship between core self-evaluations and career adaptability; (3) meritocratic beliefs not only moderated the effect protean career attitudes have on career adaptability but also moderated the indirect influence of core self-evaluations on career adaptability through protean career attitudes. These results extend the existing antecedent studies on career adaptability and demonstrate the importance of combining self-mobility beliefs (protean career attitudes) with social mobility beliefs (meritocratic beliefs) in the process of core self-evaluations affecting career adaptability.

Do I decide my career? Linking career stress, career exploration, and future work self to career planning or indecision.

Career planning and career decision are important tasks for college students. The process may be affected by career stress, career exploration, and future work self, with some students facing career indecision. Combining both construction career and proactive motivation model, this study investigated the relationships between career stress, career exploration, future work self, career planning and career indecision among 1,012 Chinese college students using the Structure equation model (SEM) to test the proposed mediation model.

Different Dimensions of Grit as the Predictor of Job-Search Intensity and Clarity.

Job-search is considered as a developmental task for college students to move from campus to workplace. Based on the self-determination theory, 859 Chinese college students were selected as the study sample and hierarchical regression analysis was used to explore the perseverance of effort and consistency of interest on job-search intensity and clarity. The survey showed that the perseverance of effort has a significant positive effect on the job-search intensity, while it has no significant positive effect on job-search clarity.

The Effect of Grit on Career Adaptability of Chinese College Students Based on the Self-Regulatory Processes.

Intelligence is innate, but grit is something everyone can develop. Grit not only enables students to stick to their goals, but also to persevere even when they fail. Career adaptability is an important concept in vocational education of college students, which is a person engaged in some work, must have a certain physical and psychological quality.

Effect of Proactive Personality on Career Decidedness: The Mediating Role of Career Exploration and the Moderating Role of Anticipated Regret.

In order to deepen the understanding of the personality antecedents of students' career decidedness, this study, based on social cognitive career theory and career development theory, examined the effect of proactive personality on career decidedness as well as the mediating mechanism and moderating factors in this process. The results of the survey of 783 Chinese college students showed that proactive personality was positively related to career decidedness career exploration, and anticipated regret moderated the relationship between proactive personality and career exploration significantly. Both theoretical and practical implications are discussed at the end of this research.

Preparation and characterization of vanillin-chitosan Schiff base zinc complex for a novel Zn sustained released system.

In this work, a novel sustained released system (VCSB-Zn(II)) for zinc supplements was built by vanillin-chitosan Schiff base (VCSB) chelated with Zn to improve the zinc trace element utilization ratio. Samples were characterized by FT-IR, H NMR, XRD, SEM, and TGA. The results showed that VCSB exhibited a more excellent chelation capacity of Zn than chitosan.

Sintilimab plus sorafenib: a novel regimen for hepatocellular carcinoma.

Hepatocellular carcinoma is one of the most common malignant tumors in China and is also a major cause of cancer deaths worldwide. Recent advances in immunotherapy have identified new treatments in which immunotherapy can be combined with antiangiogenic therapy. We report a case of hepatocellular carcinoma with a tumor thrombus at the inferior vena cava-right atrium junction and multiple lung metastases after a multiple-course treatment.

Preliminary Study on the Effect of 4DCT-Ventilation-Weighted Dose on the Radiation Induced Pneumonia Probability (RIPP).

Purpose: The purpose of the present study was to evaluate the feasibility of using 4-dimensional computed tomography (4DCT)-ventilation-weighted dose analysis to predict radiation-induced pneumonia probability (RIPP).

Methods And Materials: The study population for this retrospective analysis included 16 patients with stage III lung cancer. Each patient's 4DCT images, including end-inhale and end-exhale sequences, were used for the deformable image registration, and the Hounsfield units (HU) density-change was used to calculate the ventilation.

Recent updates on Sintilimab in solid tumor immunotherapy.

In recent years, there have been advancements in traditional patterns of tumor therapy with the adoption of immunotherapy. Its application with or without other combined regimens has attracted attention from clinicians. Sintilimab (Tyvyt®), a highly selective fully human IgG4 monoclonal antibody, blocks the binding site of programmed cell death protein 1 (PD-1), thereby, inhibiting the interaction between PD-1 and its ligands (PD-L1/2) to restore the endogenous anti-tumor T cell responses.

[Erratum] circRNA_001275 upregulates Wnt7a expression by competitively sponging miR‑370‑3p to promote cisplatin resistance in esophageal cancer.

Following the publication of the above article, the authors have realized that certain intended corrections were not carried over to the published version of the article. First, the description of the results of Figs. 5 and 6 did not match the figures; Edu and Transwell invasion assays were intended to have been excluded from the manuscript during the proofreading stage, although these data were presented in the description of the results for Figs.

Test the Effectiveness of Quantitative Linear-Quadratic-Based (qLQB) Model on Evaluating Irradiation-Induced Liver Injury (ILI) Against Normal Tissue Complication Probability (NTCP).

Objectives: To test the effectiveness of quantitative linear-quadratic-based (qLQB) model on evaluating irradiation-induced liver injury (ILI) and establish the relation between the damaged ratio/percent (DRP) in qLQB model and normal tissue complication probility (NTCP).

Materials And Methods: We established the qLQB model to calculate the ratio/percent (RP) between damaged cell/functional subunit (FSU) and entire cell/FSU of liver for radiation dose response, tested the qLQB against the Lyman-Kutcher-Burman (LKB) model, and established relation between the RP and NTCP through analyzing the dose of 32 patients with cancer of abdominal cavity who were treated with radiation therapy at our department. Based on varied α/β and varied parameters for NTCP, we put the calculated results into varied arrays for the next analysis.

Novel Potential Therapeutic Target for E2F1 and Prognostic Factors of E2F1/2/3/5/7/8 in Human Gastric Cancer.

E2F transcription factors (E2Fs) were found to be related with cell activities and disease progression among a variety of different tumors, including regulating cell division and cell proliferation. In the analysis, it aimed to focus on transcriptional and survival information of E2Fs in gastric cancer (GC) from Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan-Meier plotter, cBioPortal, Database for Annotation, Visualization and Integrated Discovery (DAVID), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and Oncomine databases. It was found that the expression of E2F1/2/3/5/7/8 in GC tissues was obviously higher than the normal.

Eye-Level Street Greenery and Walking Behaviors of Older Adults.

Evidence suggests that built environment characteristics affect older adults' travel activity behaviors, e.g., walking and cycling, which have well-established health benefits.

Study on the ability of 3D gamma analysis and bio-mathematical model in detecting dose changes caused by dose-calculation-grid-size (DCGS).

Objective: To explore the efficacy and sensitivity of 3D gamma analysis and bio-mathematical model for cervical cancer in detecting dose changes caused by dose-calculation-grid-size (DCGS).

Methods: 17 patients' plans for cervical cancer were enrolled (Pinnacle TPS, VMAT), and the DCGS was changed from 2.0 mm to 5.

circRNA_001275 upregulates Wnt7a expression by competitively sponging miR‑370‑3p to promote cisplatin resistance in esophageal cancer.

Circular RNAs (circRNAs) are aberrantly expressed in various tumors and are associated with tumorigenesis. The present study aimed to determine the role of circRNA_001275 in cisplatin‑resistant esophageal cancer. Three pairs of cisplatin‑resistant tissues and corresponding adjacent tissues were collected and subjected to circRNA chip analysis.

Exploring the Limitations of the Shielding Function of Categorization Rules in Task-Switching.

Applying categorization rules narrows attention toward the relevant features of a target and helps participants to ignore the irrelevant features of the target. This is called the shielding function of categorization rules. Here we explored the limitation of the shielding function in two task-switching experiments.

Target-Response Associations Can Produce Response-Congruency Effects Without Task-Switching Costs.

In task-switching experiments with bivalent target stimuli, conflicts during response selection give rise to response-congruency effects. Typically, participants respond more slowly and make more errors in trials with incongruent targets that require different responses in the two tasks, compared to trials with congruent targets that are associated with the same response in both tasks. Here we investigate whether participants show response-congruency effects when task rules are not made explicit.

Task-switching costs disappear if non-Chinese participants respond to Chinese characters.

In experiments with univalent target stimuli, task-switching costs can be eliminated if participants are unaware of the task rules and apply cue-target-response associations. However, in experiments with bivalent target stimuli, participants show task-switching costs. Participants may exhibit switch costs even when no task rules are provided in the instructions because they can infer the task rules.

Mechanical, Anisotropic, and Electronic Properties of XN (X = C, Si, Ge): Theoretical Investigations.

The structural, mechanical, elastic anisotropic, and electronic properties of -XN (X = C, Si, Ge) are investigated in this work using the Perdew-Burke-Ernzerhof (PBE) functional, Perdew-Burke-Ernzerhof for solids (PBEsol) functional, and Ceperly and Alder, parameterized by Perdew and Zunger (CA-PZ) functional in the framework of density functional theory. The achieved results for the lattice parameters and band gap of -CN with the PBE functional in this research are in good accordance with other theoretical results. The band structures of -XN (X = C, Si, Ge) show that -SiN and -GeN are both direct band gap semiconductor materials with a band gap of 3.

Theoretical Investigations of Si-Ge Alloys in P4₂/ncm Phase: First-Principles Calculations.

The structural, mechanical, anisotropic, electronic and thermal properties of Si, SiGe, SiGe and Ge in 4₂/ phase are investigated in this work. The calculations have been performed with an ultra-soft pseudopotential by using the generalized gradient approximation and local density approximation in the framework of density functional theory. The achieved results for the lattice constants and band gaps of 4₂/-Si and 4₂/-Ge in this research have good accordance with other results.

Role and mechanism of PTEN in adiponectin-induced osteogenesis in human bone marrow mesenchymal stem cells.

Human bone marrow-derived stromal cells (hBMSC) are multi-potent stem cells that can differentiate into osteogenic and adipogenic lineages. Adiponectin (APN) is an adipocyte-derived hormone that modulates a series of metabolic processes. Recent studies revealed a relationship between APN and bone regeneration, though the underlying mechanism was not fully examined.