Publications by authors named "Xuhe Zhao"
Magnetic compression anastomosis (MCA) for esophageal stenosis requires the insertion of magnets through two channels, transoral and transgastrostomy. Herein, we designed a Y-Z deformable self-assembled magnetic anastomosis ring (Y-Z DSAMAR) for esophageal stricture anastomosis through the transoral passage only. We introduce a Y-Z DSAMAR and verify its feasibility for single-access esophageal stenosis anastomosis in isolated organs.
View Article and Find Full Text PDFArticle Synopsis
- Researchers found that endoscopic magnetic compression anastomosis (MCA) in the gastrointestinal tract leads to a higher risk of stenosis, or narrowing of the anastomosis.
- They conducted a study on Sprague-Dawley rats, comparing outcomes between a high-tension group and a control group with no tension during surgery.
- Results indicated that the high-tension group had significantly smaller anastomotic diameters and showed more collagen fiber buildup, supporting the idea that increased tissue tension contributes to stenosis in anastomoses, leading to the proposal of the Yan-Zhang's Tissue Tension Theory.
Various surgical methods have so far been developed for treating rectovaginal fistula (RVF), each with its own advantages and disadvantages. The lack of standardized animal models of RVF is a major reason for the failure to establish a unified and effective surgical method for the treatment of RVF. This study aimed to explore the feasibility of an RVF animal model by magnetic compression and compare it with the traditional modeling method.
View Article and Find Full Text PDFPyridostigmine attenuates hypertension by inhibiting activation of the renin-angiotensin system in the hypothalamic paraventricular nucleus.
Naunyn Schmiedebergs Arch Pharmacol
October 2024
Article Synopsis
- - Activation of the renin-angiotensin system (RAS) leads to oxidative stress and inflammation in the hypothalamic paraventricular nucleus (PVN), causing sympathetic hyperactivity and contributing to hypertension.
- - A study on 2-kidney one-clip (2K1C) rats found that pyridostigmine improved cardiovascular function and lowered blood pressure by restoring autonomic balance and reducing levels of inflammatory cytokines and oxidative stress markers in the PVN.
- - Pyridostigmine also inhibited the RAS in the PVN by decreasing levels of angiotensin-converting enzyme (ACE) and angiotensin II, while increasing expression of the angiotensin II type 2 receptor