ROK family regulator NagC promotes prodigiosin biosynthesis independent of -acetylglucosamine in sp. ATCC 39006.

Unlabelled: sp. ATCC 39006 is an important model strain for the study of prodigiosin production, whose prodigiosin biosynthesis genes () are arranged in an operon. Several transcription factors have been shown to control the transcription of the operon.

cAMP and c-di-GMP synergistically support biofilm maintenance through the direct interaction of their effectors.

Nucleotide second messengers, such as cAMP and c-di-GMP, regulate many physiological processes in bacteria, including biofilm formation. There is evidence of cross-talk between pathways mediated by c-di-GMP and those mediated by the cAMP receptor protein (CRP), but the mechanisms are often unclear. Here, we show that cAMP-CRP modulates biofilm maintenance in Shewanella putrefaciens not only via its known effects on gene transcription, but also through direct interaction with a putative c-di-GMP effector on the inner membrane, BpfD.

Organic Hydroperoxide Induces Prodigiosin Biosynthesis in sp. ATCC 39006 in an OhrR-Dependent Manner.

The biosynthesis of prodigiosin in the model prodigiosin-producing strain, sp. ATCC 39006, is significantly influenced by environmental and cellular signals. However, a comprehensive regulatory mechanism for this process has not been well established.

Fnr Negatively Regulates Prodigiosin Synthesis in sp. ATCC 39006 During Aerobic Fermentation.

The well-known Crp/Fnr family regulator Fnr has long been recognized as an oxygen sensor to regulate multiple biological processes, including the switch between aerobic/anaerobic metabolism, nitrogen fixation, bioluminescence, infection, and virulence. In most cases, Fnr was found to be active under anaerobic conditions. However, its role in aerobic antibiotic metabolism has not yet been revealed.

The Cyclic AMP Receptor Protein, Crp, Is Required for the Decolorization of Acid Yellow 36 in CN32.

shows good application potentials in the decolorization and detoxification of azo dye wastewater. However, the molecular mechanism of decolorization is still lacking. In this study, it was found that CN32 exhibited good decolorization ability to various azo dyes, and a global regulatory protein cAMP receptor protein (Crp) was identified to be required for the decolorization of acid yellow 36 (AY) by constructing a transposon mutant library.