Association between temperature and mortality: a multi-city time series study in Sichuan Basin, southwest China.

Background: There are few multi-city studies on the association between temperature and mortality in basin climates. This study was based on the Sichuan Basin in southwest China to assess the association of basin temperature with non-accidental mortality in the population and with the temperature-related mortality burden.

Methods: Daily mortality data, meteorological and air pollution data were collected for four cities in the Sichuan Basin of southwest China.

The association between perchlorate in drinking water and height and weight of children and adolescents in Southwest China: a retrospective cross-sectional study.

Objective: To investigate the association between the concentration of perchlorate in drinking water and the height and weight of children and adolescents in Sichuan Province.

Methods: Perchlorate in the drinking water of 24 counties in Sichuan Province from 2021 to 2022 was detected and analyzed, 66 drinking water samples were collected, and the content of perchlorate in drinking water during the wet season and dry season was detected by ultra-high performance liquid chromatography in series. The linear mixed effect model was used to estimate the relationship between perchlorate in drinking water and the height and weight of 144,644 children and adolescents, and 33 pieces of local average wage data were used as confounding factors for quality control.

Impacts of exposure to humidex on cardiovascular mortality: a multi-city study in Southwest China.

Background: Many studies have reported the association between ambient temperature and mortality from cardiovascular disease (CVD). However, the health effects of humidity are still unclear, much less the combined effects of temperature and humidity. In this study, we used humidex to quantify the effect of temperature and humidity combined on CVD mortality.

Low-dose Cu exposure enhanced α-synuclein accumulation associates with mitochondrial impairments in mice model of Parkinson's disease.

Parkinson's disease (PD) is a neurodegenerative disorder that mainly affects the elder population, and its etiology is enigmatic. Both environmental risks and genetics may influence the development of PD. Excess copper causes neurotoxicity and accelerates the progression of neurodegenerative diseases.

Association between spicy food and hypertension among Han Chinese aged 30-79 years in Sichuan Basin: a population-based cross-sectional study.

Background: While spicy food is believed to have cardiovascular-protective effects, its impact on hypertension remains uncertain due to conflicting findings from previous studies. This study aimed to explore the association between spicy food and hypertension in Sichuan Basin, China.

Methods: The baseline data of 43,657 residents aged 30-79 in the Sichuan Basin were analyzed including a questionnaire survey (e.

Probable Evidence of Aerosol Transmission of SARS-COV-2 in a COVID-19 Outbreak of a High-Rise Building.

Although it is well established that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be transmitted through aerosols, the mode of long-range aerosol transmission in high-rise buildings remains unclear. In this study, we analyzed an outbreak of coronavirus disease 2019 (COVID-19) that occurred in a high-rise building in China. Our objective was to investigate the plausibility of aerosol transmission of SARS-CoV-2 by testing relevant environmental variables and measuring the dispersion of a tracer gas in the drainage system of the building.

Altitude and metabolic syndrome in China: Beneficial effects of healthy diet and physical activity.

Background: The correlation between altitude and metabolic syndrome has not been extensively studied, and the mediation effects of diet and physical activity remain unclear. We evaluated the cross-sectional correlations between altitude and metabolic syndrome and the possible mediation effects of diet and physical activity in China.

Methods: We included 89 485 participants from the China Multi-Ethnic Cohort.

Associations between major dietary patterns and blood pressure among Southwest Chinese: A cross-sectional analysis based on the China Multi-Ethnic Cohort (CMEC) study.

Background And Aims: In the less developed multi-ethnic regions (LEMRs) of Southwest China, the associations between dietary patterns and blood pressure (BP) values remain unclear. We aimed to investigate such associations and related effect modifiers.

Methods And Results: This study included 81,433 participants from the China Multi-Ethnic Cohort Study.

Effects of ambient temperature on mortality among elderly residents of Chengdu city in Southwest China, 2016-2020: a distributed-lag non-linear time series analysis.

Background: With complex changes in the global climate, it is critical to understand how ambient temperature affects health, especially in China. We aimed to assess the effects of temperature on daily mortality, including total non-accidental, cardiovascular disease (CVD), respiratory disease, cerebrovascular disease, and ischemic heart disease (IHD) mortality between 2016 and 2020 in Chengdu, China.

Methods: We obtained daily temperature and mortality data for the period 2016-2020.

Protective effect of CTRP6 on cerebral ischemia/reperfusion injury by attenuating inflammation, oxidative stress and apoptosis in PC12 cells.

The newly identified C1q/tumor necrosis factor (TNF)-related protein-6 (CTRP6) is a highly conserved paralog of adiponectin with modulatory effects on metabolism and inflammation. However, the role of CTRP6 in cerebral ischemia/reperfusion (I/R) injury remains unknown. The aim of the present study was to explore the protective effects of CTRP6 against cerebral I/R injury and elucidate the possible underlying mechanisms.

[PM and Emergency Calls for Health with Respiratory Diseases in Chengdu in 2017].

Objective: To determine the association between daily particulate matter 2.5 (PM ) mass and emergency calls for help with respiratory diseases.

Methods: Semi-parametric generalized additive model was established to determine the association between daily PM and emergency calls for help with respiratory diseases in 2017 in Chengdu, after adjustments for time trend and variations in the days of the week and weather conditions.

The relationship between airborne fine particle matter and emergency ambulance dispatches in a southwestern city in Chengdu, China.

High levels of fine particulate matter (PM) are known to cause adverse effects to human health. The goal of this study was to estimate the acute health effects of short-term exposure to ambient PM by analyzing cause-specific emergency ambulance dispatches as the endpoint in Chengdu, a city in Sichuan Province in southwest China. The ambient PM concentration of Chengdu reached 63 μg/m in 2015.

Increased damage of exon 5 of p53 gene in workers from an arsenic plant.

Mutagenesis is a multistage process. Substitution mutations can be induced by base modified through alteration of pairing property. Mutations of exon 5 and 8 of p53 gene have been found in most arsenicosis patients with precarcinomas and carcinomas, but never in arsenicosis individuals without precarcinomas and carcinomas.

[Changes of the certain genotoxicities in workers occupationally exposed to arsenic].

Objective: To study the changes of genotoxicities of workers occupationally exposed to arsenic in a mill of Yunnan Province.

Methods: The micronucleated cell and micronucleus frequency, comet rate and tail length of lymphocyte in comet assay from peripheral blood, urinary total and organic arsenic were detected and evaluated in 40 workers (exposure group), and also local people who did not contact with any poison obviously (control group).

Results: The micronucleated cell and micronucleus frequencies, the comet rate and tail length of lymphocyte in exposure groups were all more higher than those of controls (P < 0.

[Study on the location on the nucleotide of DNA lesion detected by RDPCR].

Objective: To simplify the establishing procedure of RDPCR and detect the DNA lesion on the precise position at the level of nucleic acid.

Methods: The TK6 cell was cultured and its genomic DNA was extracted and prepared to the single-stranded probes of the exon 2 of k-ras gene. The exon 2 of k-ras gene was amplified,called short fragment.

[Experiment research on the location of DNA lesion in the nucleic acid sequence].

Objective: To research on establishing a method that can detect the DNA lesion at the level of nucleic acid.

Methods: The TK6 cell was cultured and treated, the genomic DNA was extracted, and the strand cleavage was induced by the endonuclease Hinf I. Then the genomic DNA was amplified by randomized terminal linker-dependent PCR (RDPCR), and hybridized by Southern hybridization with the single-stranded probes of the exon 2 of k-ras gene.