Publications by authors named "Xufang Fan"
Background: Bronchopulmonary Dysplasia (BPD) is a chronic lung disease affecting preterm infants, with limited prevention and treatment options. Inhaled Nitric Oxide (iNO) is sometimes used to treat Persistent Pulmonary Hypertension of the Newborn (PPHN) and Hypoxemic Respiratory Failure (HRF), and its impact on BPD development remains debated.
Objective: To assess whether iNO-related factors are potential contributors to the development of BPD Grade Ⅱ-Ⅲ in very premature infants (VPI) diagnosed with PPHN or HRF at birth using Propensity Score Matching (PSM).
Article Synopsis
- This study examined the use and effects of inhaled nitric oxide (iNO) in preterm infants under 34 weeks gestational age across eight hospitals in China over a span of ten years.
- A total of 434 infants were analyzed, categorized into three gestational age groups: extremely preterm (24-27 weeks), very preterm (28-31 weeks), and moderate preterm (32-33 weeks), focusing on treatment outcomes and complications.
- Findings indicated that extremely preterm infants had the highest rates of iNO treatment and associated complications, with mortality rates inversely related to gestational age and birth weight, underscoring the importance of iNO in managing severe respiratory issues in this population.
[Analysis of ARX gene variant in a child with X-linked lissencephaly with abnormal genitalia].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
September 2023
Objective: To explore the clinical characteristics and genetic basis for a child with X-linked lissencephaly with abnormal genitalia (XLAG).
Methods: A child with XLAG who had presented at the Third Affiliated Hospital of Zhengzhou University in May 2021 was selected as the study subject. Peripheral blood samples of the child and his parents were collected and subjected to high-throughput sequencing.