Single-center experience of venetoclax combined with azacitidine in young patients with newly diagnosed acute myeloid leukemia.

Background: Medical resources, especially blood products, were in short supply during the COVID-19. Less intensive therapy with hypomethylating agents/venetoclax (VEN) seems an effective treatment option for patients with acute myeloid leukemia (AML).

Objectives: To retrospectively analyze the efficacy and safety of VEN combined with azacitidine (AZA) in young adult patients with newly diagnosed (ND) AML.

Comparison of Thrombopoietin Receptor Agonists Plus Recombinant Human Thrombopoietin versus Recombinant Human Thrombopoietin Alone for Hematopoietic Reconstruction in Multiple Myeloma Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation.

Background: Hetrombopag is a novel thrombopoietin receptor agonist that has shown an additive effect in stimulating platelet production when combined with recombinant human thrombopoietin (rhTPO). However, it remains unclear whether this combination can promote hematopoietic reconstruction after autologous stem cell transplant (ASCT).

Purpose: To compare the effect of rhTPO plus thrombopoietin receptor agonists (TPO-RA) versus rhTPO alone on hematopoietic recovery, adverse events, postoperative complications, and cost-effectiveness in patients with newly diagnosed multiple myeloma (NDMM) undergoing ASCT.

The incidence and clinical significance of monoclonal and oligoclonal protein bands in multiple myeloma patients after BCMA-CAR-T cell therapy: A retrospective study based on LEGEND-2.

The emergence of abnormal protein bands (APBs), also known as oligoclonal protein bands, has been documented in patients with multiple myeloma (MM) post hematopoietic stem cell transplantation. However, the incidence rate and clinical significance of APBs remain contentious. Few studies have explored the occurrence and prognostic implications of APBs in patients with MM treated with B-cell maturation antigen (BCMA)-specific chimeric antigen receptor (CAR)-T therapy.

cGAS/STING in skin melanoma: from molecular mechanisms to therapeutics.

Melanoma, recognized as the most aggressive type of skin cancer, has experienced a notable increase in cases, especially within populations with fair skin. This highly aggressive cancer is largely driven by UV radiation exposure, resulting in the uncontrolled growth and malignant transformation of melanocytes. The cGAS-STING pathway, an immune signaling mechanism responsible for detecting double-stranded DNA in the cytoplasm, is essential for mediating the immune response against melanoma.

Diagnosing skin cancer using social spider optimization (SSO) and error correcting output codes (ECOC) with weighted hamming distance.

Skin cancer is a common disease resulting from genetic defects, and early detection is critical to improve treatment outcomes. Diagnostic programs that use computer aid especially those that use supervised learning are very useful in early diagnosis of skin cancer. This research therefore presents a new approach that integrates optimization methods with supervised learning to improve skin cancer diagnosis using machine vision approach.

Risk score constructed with neutrophil extracellular traps-related genes predicts prognosis and immune microenvironment in multiple myeloma.

Background: Multiple myeloma (MM) exhibits considerable heterogeneity in treatment responses and survival rates, even when standardized care is administered. Ongoing efforts are focused on developing prognostic models to predict these outcomes more accurately. Recently, neutrophil extracellular traps (NETs) have emerged as a potential factor in MM progression, sparking investigation into their role in prognostication.

KIF22 promotes multiple myeloma progression by regulating the CDC25C/CDK1/cyclinB1 pathway.

Purpose: Multiple myeloma (MM) is an incurable hematological malignancy characterized by clonal proliferation of malignant plasma B cells in bone marrow, and its pathogenesis remains unknown. The aim of this study was to determine the role of kinesin family member 22 (KIF22) in MM and elucidate its molecular mechanism.

Methods: The expression of KIF22 was detected in MM patients based upon the public datasets and clinical samples.

Therapeutic and fluorescence evaluation of 20% 5-aminolevulinic acid-mediated photodynamic therapy in actinic keratosis.

Background: Actinic keratosis (AK) is a precancerous lesion that occurs in areas that are chronically exposed to sunlight and has the potential to develop into invasive cutaneous squamous cell carcinoma (cSCC). We investigated the efficacy of 20 % 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) with LED red light for the treatment of AK in Chinese patients by examining changes in dermoscopic features, histopathology and fluorescence after treatment.

Methods: Twenty-eight patients with fourty-six AK lesions from March 2022 to September 2023 were treated with 20 % ALA, and 3 h later, they were irradiated with LED red light (80-100 mW/cm) for 20 min.

BATF promotes extramedullary infiltration through TGF-β1/Smad/MMPs axis in acute myeloid leukemia.

Acute myeloid leukemia (AML) is one of the most prevalent types of leukemia and is challenging to cure for most patients. Basic Leucine Zipper ATF-Like Transcription Factor (BATF) has been reported to participate in the development and progression of numerous tumors. However, its role in AML is largely unknown.

Outcomes in patients with multiple myeloma receiving salvage treatment after BCMA-specific CAR-T therapy: A retrospective analysis of LEGEND-2.

Chimeric antigen receptor T-cell (CAR-T) therapy targeting B-cell maturation antigen (BCMA) has shown profound efficacy and manageable toxicity in patients with relapsed/refractory multiple myeloma (RRMM). However, determining the best course of treatment for post-CAR-T therapy relapse remains a significant challenge. We conducted a retrospective analysis of patients from the phase I LEGEND-2 study (NCT03090659) enrolled at the Xi'an site, analysing the first salvage line of therapy and outcomes in patients with RRMM who progressed after receiving LCAR-B38M CAR-T therapy.

A new strategy to improve the dielectric properties of cellulose nanocrystals (CNCs): Surface modification of small molecules.

Nanocellulose finds various applications in advanced electrical devices due to its impressive mechanical properties, thermal stability, and degradability. Cellulose nanocrystals (CNCs) with excellent dielectric properties may act as a fresh dielectric plastic. In this study, a new strategy of small molecule modification was used to improve the dielectric constant, breakdown strength, and band gap of the CNCs.

Real-world results of venetoclax combined with hypomethylating agents in young adults with relapsed/refractory acute myeloid leukemia.

Objectives: Young adults with acute myeloid leukemia (AML) often fail to achieve permanent complete remission (CR) and frequently relapse, indicating an urgent need to explore effective salvage therapies. Recent advances in AML treatment have been attributed to the combination of the B-cell lymphoma 2 (Bcl-2) inhibitor venetoclax (VEN) with hypomethylating agents (HMAs); however, the use of this combination in young adults with relapsed or refractory (R/R) AML has not been reported.

Methods: We retrospectively examined 31 young patients with R/R AML treated with VEN plus an HMA.

N6-methyladenosine reader YTHDF2 promotes multiple myeloma cell proliferation through EGR1/p21/CDK2-Cyclin E1 axis-mediated cell cycle transition.

Multiple myeloma (MM) is the second most common hematological malignancy. N6-methyladenosine (mA) is the most abundant RNA modification. YTH domain-containing family protein 2 (YTHDF2) recognizes mA-cotaining RNAs and accelerates degradation to regulate cancer progression.

A novel ferroptosis-related gene signature for predicting prognosis in multiple myeloma.

Background: Multiple myeloma (MM) is a highly malignant hematological tumor with a poor overall survival (OS). Due to the high heterogeneity of MM, it is necessary to explore novel markers for the prognosis prediction for MM patients. Ferroptosis is a form of regulated cell death, playing a critical role in tumorigenesis and cancer progression.

A mini-review on the dielectric properties of cellulose and nanocellulose-based materials as electronic components.

Cellulose-based materials have the advantages of renewable, non-toxic, flexible, and strong mechanical properties, so it of is great significance to study the dielectric properties of cellulose-based materials. In this paper, we summarized the factors influencing the dielectric properties of cellulose and nanocellulose-based dielectric and the ways to change the dielectric properties, mainly exploring the methods to improve the dielectric constant of cellulose-based dielectric materials. Cellulose and nanocellulose-based dielectric need to improve the hygroscopic property, increase the flexibility and reduce dielectric loss of the composite materials.

Long-term potentiation and depression regulatory microRNAs were highlighted in Bisphenol A induced learning and memory impairment by microRNA sequencing and bioinformatics analysis.

The mechanisms of Bisphenol A (BPA) induced learning and memory impairment have still not been fully elucidated. MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules involved in the process of toxicant-induced neurotoxicity. To investigate the role of miRNAs in BPA-induced learning and memory impairment, we analyzed the impacts of BPA on miRNA expression profile by high-throughput sequencing in mice hippocampus.

Carbon Dots Embedded in Cellulose Film: Programmable, Performance-Tunable, and Large-Scale Subtle Fluorescent Patterning by Laser Writing.

Fluorescent patterns with multiple functions enable high-security anti-counterfeiting labels. Complex material synthesis and patterning processes limit the application of multifunctional fluorescent patterns, so the technology of fluorescent patterning with tunable multimodal capabilities is becoming more necessary. In this work, an fluorescent patterning technology was developed using laser direct writing on solid cellulose film at ambient conditions without masks.

Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.

Background: Vitamin E has long been linked to skin health, including all of its possible functions in cosmetic products, to its roles in membrane integrity and even the aging process. However, reports on the relationship between serum vitamin E levels and the risk of chronic inflammatory skin diseases have been inconsistent. We performed a systematic review and meta-analysis to evaluate the association between serum vitamin E levels and chronic inflammatory skin diseases.

Recent Advances on Cellulose Nanocrystals and Their Derivatives.

Nanocellulose, typically cellulose nanocrystals (CNCs), has excellent properties and is widely used. In particular, CNC has a small dimension, high chemical reactivity, and high sustainability, which makes it an excellent candidate as a starting material to be converted into nanocellulose derivatives. Chemical modification is essential for obtaining the desired products; the modifications create different functional attachment levels and generate novel microstructures.

Electrospun, sepiolite-loaded poly(vinyl alcohol)/soy protein isolate nanofibers: Preparation, characterization, and their drug release behavior.

Wound management and drug release are important applications for electrospun nanofibers. In this study, poly(vinyl alcohol)/soy protein isolate (PVA/SPI) nanofiber mats were produced by electrospinning and used as drug carriers. The mats were loaded with ketoprofen by dissolving the drug in the solutions for nanofiber electrospinning.

Highly UV Resistant Inch-Scale Hybrid Perovskite Quantum Dot Papers.

Halide perovskite quantum dots (PQDs) are promising materials for diverse applications including displays, light-emitting diodes, and solar cells due to their intriguing properties such as tunable bandgap, high photoluminescence quantum yield, high absorbance, and narrow emission peaks. Despite the prosperous achievements over the past several years, PQDs face severe challenges in terms of stability under different circumstances. Currently, researchers have overcome part of the stability problem, making PQDs sustainable in water, oxygen, and polar solvents for long-term use.

Photonic Thin Films Assembled from Amphiphilic Cellulose Nanofibrils Displaying Iridescent Full-Colors.

Self-assembly of nanoparticles (NPs) to form structural colors offers promising opportunities for developing electronic, optoelectronic, and magnetic devices. In this regard, we reported co-assembly of cellulose nanofibrils (CNFs) and graphene to produce colored thin films. We demonstrated that biomimetic iridescent "peacock feather"-like full-color thin films can be generated by simple evaporation of aqueous suspensions on a surface tension confined, optically symmetric indium tin oxide-coated polyethylene terephthalate substrate.

Highly Efficient and Stable White Light-Emitting Diodes Using Perovskite Quantum Dot Paper.

Perovskite quantum dots (PQDs) are a competitive candidate for next-generation display technologies as a result of their superior photoluminescence, narrow emission, high quantum yield, and color tunability. However, due to poor thermal resistance and instability under high energy radiation, most PQD-based white light-emitting diodes (LEDs) show only modest luminous efficiency of ≈50 lm W and a short lifetime of <100 h. In this study, by incorporating cellulose nanocrystals, a new type of QD film is fabricated: CHNHPbBr PQD paper that features 91% optical absorption, intense green light emission (518 nm), and excellent stability attributed to the complexation effect between the nanocellulose and PQDs.

Transition of interfacial capacitors in electrowetting on a graphite surface by ion intercalation.

The low voltage electrowetting response of a LiCl aqueous solution on a freshly cleaved surface of highly oriented pyrolytic graphite (HOPG) is presented. For applied voltages below 1 V, the energy stored in the electrical double layer (EDL) is insufficient to drive the spreading of the drop due to the pinning of the three phase contact line at the step edges. Electrochemical impedance spectroscopy shows a dramatic increase in capacitance above 1 V, which provides a sufficient electrowetting force for depinning the contact line, resulting in a subsequent decrease of the contact angle.