Delivery of baicalein and paclitaxel using self-assembled nanoparticles: synergistic antitumor effect in vitro and in vivo.

Purpose: Combination anticancer therapy is promising to generate synergistic anticancer effects to maximize the treatment effect and overcome multidrug resistance. The aim of the study reported here was to develop multifunctional, dual-ligand, modified, self-assembled nanoparticles (NPs) for the combination delivery of baicalein (BCL) and paclitaxel (PTX) prodrugs.

Methods: Prodrug of PTX and prodrug of BCL, containing dual-targeted ligands of folate (FA) and hyaluronic acid (HA), were synthesized.

Effects of yixin jiangya capsules on insulin resistance and timor necrosis factor-alpha in cases of primary hypertension with left ventricular hypertrophy.

Objectives: To observe the effects of yixin jiangya Capsules ([Chinese characters: see text] capsules for nourishing the heart and lowering blood pressure) on insulin resistance (IR) and tumor necrosis factor-alpha (TNF-alpha) in patients with primary hypertension with left ventricular hypertrophy (LVH).

Methods: Totally 93 cases were randomly divided into a control group of 31 cases taking Enalapril and a treatment group of 62 cases taking Enalapril and yixin jiangya Capsules.

Results: Fasting serum insulin (FSI) and TNF-alpha obviously increased and insulin sensitive index (ISI) significantly decreased in both groups before treatment as compared to those of a healthy group.

[A clinical study on manshuailing oral liquid in treating elder patients with congestive heart failure of type heart and kidney yang deficiency].

Objective: To investigate the clinical effect of manshuailing oral liquid on patients with congestive heart failure of type heart and kidney Yang deficiency.

Method: 90 patients of heart failure were randomly divided into 2 groups. 45 cases in the routine treatment group (RT) received general therapy including diuretics and digitalis, and 45 cases in the Chinese herb medicine group (CH) were treated basically with the above medicine, with additional manshuailing oral liquid.

Clinical observation on shu xin yi mai capsules for prevention of recurrent stricture after coronary artery introducing treatment.

Shu Xin Yi Mai Capsules ([symbol: see text]) combined with western medicine was used in the routine treatment of 22 cases who successfully received coronary artery introducing therapy (Chinese-western medicine group), and the results was compared with the 26 cases treated routinely with simple western medicine in the control group (western medicine group). It was found that both the recurrence rate of angina pectoris and the incidence rate of recurrent stricture in the Chinese-western medicine group were significantly lower than that in the control group (both P < 0.05).