Single-centre, randomised and double-blind clinical trial on the efficacy of transcutaneous auricular vagus nerve stimulation in preventing and treating primary headache in children and adolescents: a study protocol.

Introduction: Primary headaches pose a significant burden on children and adolescents, highlighting the need for effective non-pharmacological interventions. Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive modality that has demonstrated efficacy in adult populations with primary headaches and has shown safety in adolescents with mental health disorders. However, its effectiveness in managing acute headache episodes and preventing recurrences in paediatric populations remains underexplored.

Closed-loop transcutaneous auricular vagus nerve stimulation for the improvement of upper extremity motor function in stroke patients: a study protocol.

Background: Transcutaneous auricular vagus nerve stimulation (taVNS) has garnered attention for stroke rehabilitation, with studies demonstrating its benefits when combined with motor rehabilitative training or delivered before motor training. The necessity of concurrently applying taVNS with motor training for post-stroke motor rehabilitation remains unclear. We aimed to investigate the necessity and advantages of applying the taVNS concurrently with motor training by an electromyography (EMG)-triggered closed-loop system for post-stroke rehabilitation.

Belief in biological origin of race (racial essentialism) increases sensitivities to cultural category changes measured by ERP mismatch negativity (MMN).

The dynamic multicultural view explains culture-specific effects on cognition that cultural knowledge is organized in multiple knowledge systems which are specific to each culture and differentially activated when exposed to related objects or scenes. This view predicts automatic categorizations of environmental information according to the culture-specific knowledge systems. This study investigated whether cultural information could be spontaneously categorized, and the modulation of this process by the belief in the biological origin of race (i.

Frontotemporal network in automatic / pre-attentive detection of abstract change: An event-related optical signal (EROS) study.

The human brain constantly monitors the environment for unexpected changes. Under the prediction violation account, the Inferior Frontal Cortex (IFC) is involved in prediction-related processes for deviance detection processes in the Superior Temporal Cortex (STC). Consistent with this account, previous studies revealed an IFC-to-STC-followed-by-IFC mismatch response pattern to physical changes using event-related optical signals (EROS).

Fronto-occipital mismatch responses in pre-attentive detection of visual changes: Implication on a generic brain network underlying Mismatch Negativity (MMN).

Current theories of pre-attentive change detection suggest a regularity or prediction violation mechanism involving a frontotemporal network. Modulations of the early inferior frontal cortex (IFC) mismatch response representing the effort in comparing a stimulus to the prediction, the superior temporal cortex (STC) response indicating deviance detection, and the late IFC response representing prediction model updating were consistently demonstrated in auditory change detection using event-related optical signal (EROS). If the prediction violation hypothesis is universal, a generic neural mechanism should be found in all sensory modalities.

The critical role of the inferior frontal cortex in establishing a prediction model for generating subsequent mismatch negativity (MMN): A TMS-EEG study.

Background: The prediction violation account of automatic or pre-attentive change detection assumed that the inferior frontal cortex (IFC) is involved in establishing a prediction model for detecting unexpected changes. Evidence supporting the IFC's contribution to prediction model is mainly based on the Mismatch Negativity (MMN) to deviants violating predictions that are established based on the frequently presented standard events. However, deviant detection involves processes, such as events comparison, other than prediction model establishment.

Functional connectivity of the frontotemporal network in preattentive detection of abstract changes: Perturbs and observes with transcranial magnetic stimulation and event-related optical signal.

Current theories of automatic or preattentive change detection suggest a regularity or prediction violation mechanism involving functional connectivity between the inferior frontal cortex (IFC) and the superior temporal cortex (STC). By disrupting the IFC function with transcranial magnetic stimulation (TMS) and recording the later STC mismatch response with event-related optical signal (EROS), previous study demonstrated a causal IFC-to-STC functional connection in detecting a pitch or physical change. However, physical change detection can be achieved by memory comparison of the physical features and may not necessarily involve regularity/rule extraction and prediction.

Establishing the functional connectivity of the frontotemporal network in pre-attentive change detection with Transcranial Magnetic Stimulation and event-related optical signal.

Current theories of pre-attentive deviant detection postulate that before the Superior Temporal Cortex (STC) detects a change, the Inferior Frontal Cortex (IFC) engages in stimulus analysis, which is particularly critical for ambiguous deviations (e.g., deviant preceded by a short train of standards).

Detecting violation in abstract pitch patterns with mismatch negativity.

The human brain automatically extracts regularities embedded in environmental auditory events. This study investigated the extraction of abstract patterns by measuring mismatch negativity (MMN). Participants watched a silent subtitled movie and ignored a sequence of auditory events comprising frequent standards and rare deviants presented in the background.