Anion-Regulated Ionic Covalent Organic Frameworks for Highly Selective Recovery of Gold from E-Waste.

The existing electronic waste (e-waste) and leaching solutions generated by industries accumulate significant amounts of gold (Au), even in excess of those in natural minerals. Therefore, the recycling of Au is extremely significant for the potential sustainability of chemical industry. By designing ionic covalent organic frameworks (COFs), here we synthesize a series of Ionic-COF-X (X=Cl, Br, AcO, and SO ) by anion regulation strategy and further explore their adsorption performance towards Au recovery.

Therapeutic plasma exchange combined with ribavirin to rescue critical SFTS patients.

Background: Severe fever with thrombocytopenia syndrome (SFTS) is a zoonotic infectious disease caused by the severe fever with thrombocytopenia syndrome virus (SFTSV). Endemic in East Asia, SFTS is characterized by an exceptionally high mortality rate. Presently, there is no established treatment for SFTS, particularly for patients in critical condition.

A nomogram to predict mortality in patients with severe fever with thrombocytopenia syndrome.

Severe fever with thrombocytopenia syndrome (SFTS) is an acute infectious disease caused by a novel Bunyavirus infection with low population immunity and high mortality rate. Lacking specific therapies, the treatment measures vary with the severity of the disease, therefore, a case control study involved 394 SFTS patients was taken to determine risk factors for mortality. Comparative clinical data from the first 24 h after admission was collected through the electronic medical record system.

Winogradskyella marina sp. nov., isolated from marine sediment.

A Gram-stain-negative, rod-shaped (0.3-0.6 × 0.

Pontibaca salina sp. nov., isolated from marine sediment.

A Gram-stain-negative, oval or short rod-shaped, non-motile, aerobic bacterium, designated strain S1109L, was isolated from a marine sediment in Weihai, PR China. Cells were oxidase positive and catalase positive. Growth of strain S1109L occurred at 10-40 °C (optimum, 30-33 °C), pH 6.

LncRNA ANCR Suppresses the Progression of Hepatocellular Carcinoma Through the Inhibition of Wnt/β-Catenin Signaling Pathway.

Objective: Our study aimed to investigate the effect of anti-differentiation noncoding RNA () on hepatocellular carcinoma (HCC) and its potential molecular mechanisms.

Methods: The expression of was detected by qRT-RCR in both HCC tissues and HCC cells. Moreover, the relationship between expression and clinical parameters in HCC patients was investigated.

Dual turn-on fluorescence signal-based controlled release system for real-time monitoring of drug release dynamics in living cells and tumor tissues.

Controlled release systems with capabilities for direct and real-time monitoring of the release and dynamics of drugs in living systems are of great value for cancer chemotherapy. Herein, we describe a novel dual turn-on fluorescence signal-based controlled release system (), in which the chemotherapy drug doxorubicin () and the fluorescent dye () are conjugated by a hydrazone moiety, a pH-responsive cleavable linker. itself shows nearly no fluorescence as the fluorescence of and is essentially quenched by the C=N isomerization and N-N free rotation.

Construction of a ratiometric fluorescent probe with an extremely large emission shift for imaging hypochlorite in living cells.

Hypochlorite is one of the important reactive oxygen species (ROS) and plays critical roles in many biologically vital processes. Herein, we present a unique ratiometric fluorescent probe (CBP) with an extremely large emission shift for detecting hypochlorite in living cells. Utilizing positively charged α,β-unsaturated carbonyl group as the reaction site, the probe CBP itself exhibited near-infrared (NIR) fluorescence at 662nm, and can display strong blue fluorescence at 456nm when responded to hypochlorite.

A unique red-emitting two-photon fluorescent probe with tumor-specificity for imaging in living cells and tissues.

Tumor-specific imaging can provide an attractive approach for the early detection and prognosis of cancer, as well as the precise image-guided tumor-removal surgery. Herein, we describe a unique red-emitting two-photon fluorescent probe (N-BN) for tumor-specific imaging. N-BN utilized Nile Red as the red-emitting two-photon fluorophore and employed biotin as the tumor-specific ligand.

Two-photon red-emissive fluorescent probe for imaging nitroxyl (HNO) in living cells and tissues.

Nitroxyl (HNO) plays important roles in the regulation of many physiological and pathological processes, and can serve as a potential therapeutic agent for cardiovascular disease. The development of HNO detection in living systems is greatly important for in-depth studies of its biosynthesis and activities. Herein, we describe a novel two-photon red-emissive fluorescence probe (RP) for imaging HNO in living cells and tissues.

A cancer cell-specific fluorescent probe for imaging Cu in living cancer cells.

Monitoring copper level in cancer cells is important for the further understanding of its roles in the cell proliferation, and also could afford novel copper-based strategy for the cancer therapy. Herein, we have developed a novel cancer cell-specific fluorescent probe for the detecting Cu in living cancer cells. The probe employed biotin as the cancer cell-specific group.

A tumor-targeting and lysosome-specific two-photon fluorescent probe for imaging pH changes in living cells.

Lysosomal pH is closely related to the metastasis and apoptosis of cancer cells. Detecting lysosomal pH changes in cancer cells could be helpful for analyzing tumor progressions and in-depth study of the roles of lysosomes in tumor invasion and metastasis. Herein, we describe a novel tumor-targeting and lysosome-specific two-photon fluorescent probe (BN-lys) for imaging pH changes for the first time.

Simultaneous Near-Infrared and Two-Photon In Vivo Imaging of H O Using a Ratiometric Fluorescent Probe based on the Unique Oxidative Rearrangement of Oxonium.

A new ratiometric fluorescent H O probe, benzopyrylium-coumarin (BC), is designed by using an oxonium moiety as the unique H O response site. The BC probe exhibits an extremely large emission shift of 221 nm in response to H O , and is successfully applied for the simultaneous near-infrared and two-photon imaging of H O in living cells, mouse-liver tissues, and zebrafish.

Dual Site-Controlled and Lysosome-Targeted Intramolecular Charge Transfer-Photoinduced Electron Transfer-Fluorescence Resonance Energy Transfer Fluorescent Probe for Monitoring pH Changes in Living Cells.

Acidic pH is a critical physiological factor for controlling the activities and functions of lysosome. Herein, we report a novel dual site-controlled and lysosome-targeted intramolecular charge transfer-photoinduced electron transfer-Fluorescence resonance energy transfer (ICT-PET-FRET) fluorescent probe (CN-pH), which was essentially the combination of a turn-on pH probe (CN-1) and a turn-off pH probe (CN-2) by a nonconjugated linker. Coumarin and naphthalimide fluorophores were selected as donor and acceptor to construct the FRET platform.

Reproductive Factors, Steroid Receptor Status, and Tumour Markers of HER2-Positive Breast Cancer in Northern China.

Background: Although China has a breast cancer incidence that surpasses all other cancer registries, there have been few reports to evaluate the relationships of reproductive history, steroid receptor status, and tumour markers with HER2 status of breast cancer.

Patients And Methods: This project included 274 primary invasive ductal breast cancer patients. Information concerning the reproductive factors and tumour characteristics of the patients had previously been collected.