Effectively managing infected diabetic wounds involves the elimination of bacteria, neutralization of reactive oxygen species (ROS), suppression of inflammation, and induction of angiogenesis. This study describes the development of a multifunctional hyaluronic acid (HA)-based microgel system capable of serving as either an injectable wet microgel or dry microspheres (MSs). After initially engineering Fe/tea polyphenol (TP) metal-polyphenol network (MPN)-functionalized HAMA MS, these particles were found to suppress inflammation and facilitate ROS scavenging.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
The progression of intervertebral disc degeneration (IVDD) is associated with increased cell apoptosis and reduced extracellular matrix (ECM) production, both of which are driven by ongoing inflammation. Thus, alleviating the acidic inflammatory microenvironment and mitigating the apoptosis of nucleus pulposus cells (NPCs) are essential for intervertebral disc (IVD) regeneration. Regulating pH levels in the local environment can reduce inflammation and promote tissue recovery.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2024
Introduction: The dysbiosis of the oral microbiome is associated with the progression of various systemic diseases, including diabetes. However, the precise causal relationships remain elusive. This study aims to investigate the potential causal associations between oral microbiome and type 2 diabetes (T2D) using Mendelian randomization (MR) analyses.
View Article and Find Full Text PDFIEEE Trans Neural Syst Rehabil Eng
January 2024
Due to the problem of a small amount of EEG samples and relatively high dimensionality of electroencephalogram (EEG) features, feature selection plays an essential role in EEG-based emotion recognition. However, current EEG-based emotion recognition studies utilize a problem transformation approach to transform multi-dimension emotional labels into single-dimension labels, and then implement commonly used single-label feature selection methods to search feature subsets, which ignores the relations between different emotional dimensions. To tackle the problem, we propose an efficient EEG feature selection method for multi-dimension emotion recognition (EFSMDER) via local and global label relevance.
View Article and Find Full Text PDFIntroduction: Breast cancer is the most common malignancy among women. Previous studies had shown that hepatitis C virus (HCV) infection might serve as a risk factor for breast cancer, while some studies failed to find such an association.
Methods: In this study, we presented a first attempt to capture and clarify this clinical debate via a cumulative analysis (registration ID: CRD42023445888).
Biochem Biophys Res Commun
October 2023
Background: Chemoresistance, i.e., resistance to cisplatin (DDP), has been a major obstacle to ovarian cancer treatment.
View Article and Find Full Text PDFIEEE Trans Neural Syst Rehabil Eng
February 2023
Individual differences among different subjects pose a great challenge to motor imagery (MI) decoding. Multi-source transfer learning (MSTL) is one of the most promising ways to reduce individual differences, which can utilize rich information and align the data distribution among different subjects. However, most MSTL methods in MI-BCI combine all data in the source subjects into a single mixed domain, which will ignore the effect of important samples and the large differences in multiple source subjects.
View Article and Find Full Text PDFIEEE Trans Neural Netw Learn Syst
May 2021
Effective features can improve the performance of a model and help us understand the characteristics and underlying structure of complex data. Previously proposed feature selection methods usually cannot retain more discriminative information. To address this shortcoming, we propose a novel supervised orthogonal least square regression model with feature weighting for feature selection.
View Article and Find Full Text PDFJ Neuropsychiatry Clin Neurosci
February 2014
An fMRI study was launched to understand mechanisms of Alzheimer's disease (AD) patients with apathy. The authors reviewed 7 AD patients with apathy and 6 AD patients without apathy. The block method was adopted, and 24 pictures representing positive, negative, and neutral emotional stimuli were viewed when patients were given brain fMRI.
View Article and Find Full Text PDFObjective: To investigate the value of hepatocellular carcinoma pretreatment apparent diffusion coefficients (ADCs) and its ADCs changes after treatment in predicting and early monitoring the response after chemoembolization.
Materials And Methods: Twenty-five responding and nine nonresponding hepatocellular carcinoma lesions were prospectively evaluated with magnetic resonance diffusion-weighted imaging in 24 h before and in 48 h after chemoembolization. Quantitative ADC maps were calculated with images with b values of 0 and 500 s/mm(2).