Highly Fused Lindenane Sesquiterpenoid Dimers with Apoptosis-Inducing Properties from var. .

Six undescribed lindenane sesquiterpenoid dimers (LSDs), shimianolides A-F (-), were isolated from the whole plants of var. . Shimianolides A-C (-) represent an unprecedented class of LSDs, distinguished by a highly fused 3/5/6/6/6/5/6/6/5/3 decacyclic scaffold.

Discovery, Isolation, and Characterization of 23-Spirocholestane Derivatives as Novel Plant Root Growth Inhibitors from .

In the present study, we first discovered that the 70% ethanol extract of significantly inhibited root growth. Through a bioactivity-guided strategy, 18 rare 23-spirocholestane derivatives (-), including 12 new ones (-), featuring a dioxane ring between C-24/C-23 of the aglycone moiety and C-1/C-2 of the d-fucose ligand, were obtained from the strongest active elution fraction. Their structures were elucidated via a comprehensive method of MS and NMR spectroscopy, single-crystal X-ray diffraction, and chemical methods.

Analysis of genotype resistance and HIV-1 transmission risk in HIV-1-infected men who have sex with men in Guiyang, China.

Background: As the social economy has developed and population mobility has increased, differences in the Human immunodeficiency virus type 1 (HIV-1) genotype distribution among men who have sex with men (MSM) have become apparent in the provinces and cities across China. The high variability and drug resistance characteristics of HIV-1 can lead to the widespread spread of resistant strains, which may also result in antiretroviral therapy failure and an increase in the mortality rate.

Objective: The genotypic drug resistance characteristics and HIV-1 transmission risks among HIV-1-infected MSM in Guiyang, Guizhou Province were analyzed in the current study.

Sequencing of cerebrospinal fluid cell-free DNA facilitated early differential diagnosis of intramedullary spinal cord tumors.

Pre-surgery differential diagnosis is valuable for personalized treatment planning in intramedullary spinal cord tumors. This study assessed the performance of sequencing cell-free DNA (cfDNA) in cerebrospinal fluid (CSF) for differential diagnosis of these tumors. Prospectively enrolling 45 patients with intramedullary spinal cord lesions, including diffuse midline glioma (DMG), H3K27-altered (14/45), glioblastoma (1/45), H3-wildtype-astrocytoma (10/45), ependymoma (11/45), and other lesions (9/45), CSF samples were collected via lumbar puncture (41/45), intraoperative extraction (3/45), and Ommaya reservoir (1/45).

All-normal dispersion widely tunable dual-wavelength mode-locked fiber laser based on NALM.

We experimentally and numerically demonstrate the all-normal dispersion (ANDi) ytterbium (Yb)-doped fiber laser based on nonlinear amplifying loop mirror (NALM) mode-locked, which allows tunable single-wavelength and dual-wavelength outputs. The pulses tuning ranges of the dual-wavelength are from 1032.24 nm to 1053.

First report of causing root rot of tea plants () in China.

Root rot is an important disease of tea plants owing to its unobvious early symptoms and permanent damage (Huu et al. 2016). In 2019, 5% of tea plants displayed symptoms consistent with root rot in a tea plantation (28°09'N, 113°13'E) located in Changsha city, Hunan province of China.

[Validity of the Inpatient Satisfaction Questionnaire].

Objective: To assess the validity of the self-designed inpatient satisfaction questionnaire using Structural Equation Model (SEM).

Methods: The questionnaire survey was conducted in a tertiary hospital in Sichuan in April 2016,with participants selected through a systematical sampling approach. The structural validity of the inpatient satisfaction questionnaire was assessed using SEM.

Relationship between maternal exposure to bisphenol S and pregnancy duration.

Bisphenol S (BPS) has been progressively used due to the potential safety problems of bisphenol A (BPA). Thus Human studies are needed to investigate the developmental effects of BPS. In this study, the impact of maternal BPS exposure on birth outcomes was evaluated with linear and logistic regression models.

A multiregional survey of nickel in outdoor air particulate matter in China: Implication for human exposure.

Nickel is a widespread environmental contaminant, and it is toxic to humans in certain forms at high doses. Despite this, nationwide data on nickel in outdoor air particulate matter and human exposure to nickel through inhalation in China are limited. In the present study, 662 outdoor air samples from seven representative provinces such as Shanghai, Hubei, Hunan, Hebei, Guangdong, Yunnan, and Shanxi were collected between March 2013 and February 2014 and analyzed by inductively coupled plasma mass spectrometry.

Binding mechanism of CDK5 with roscovitine derivatives based on molecular dynamics simulations and MM/PBSA methods.

Roscovitine derivatives are potent inhibitors of cyclin-dependent kinase 5 (CDK5), but they exhibit different activities, which has not been understood clearly up to now. On the other hand, the task of drug design is difficult because of the fuzzy binding mechanism. In this context, the methods of molecular docking, molecular dynamics (MD) simulation, and binding free energy analysis are applied to investigate and reveal the detailed binding mechanism of four roscovitine derivatives with CDK5.

Determination of 4-tert-octylphenol in surface water samples of Jinan in China by solid phase extraction coupled with GC-MS.

Octylphenols, considered as xenoestrogens, mainly exist as 4-tert-octylphenol (OP) in aquatic environments. The high stability and accumulation of OP in aquatic systems have caused endocrine disruption. The OP in surface water in Jinan, China was analyzed by gas chromatography-mass spectrometry (GC-MS) coupled with solid phase extraction (SPE).