Publications by authors named "Xueying S Xu"
Article Synopsis
- - Mitigating inflammation from the foreign body response (FBR) is crucial for improving implantable medical devices, but current anti-inflammatory strategies can inhibit necessary healing processes.
- - Previous research showed that the NLRP3 inflammasome inhibitor MCC950 reduced fibrosis around implants without harming tissue healing, but it failed safety trials, leading to the search for safer NLRP3 inhibitors.
- - Dapansutrile (OLT1177) shows potential as a safer NLRP3 inhibitor, demonstrating beneficial effects on cells involved in FBR and reducing fibrosis while promoting blood vessel growth in a study, making it a promising candidate for future research in improving implant integration.
