From existential anxiety to posttraumatic growth:: The stranded traveler during the pandemic outbreak.

For many, the COVID-19 pandemic is an existential trauma. Existential traumas trigger people's ultimate concerns and shatter individuals' basic assumptions. Based on the perspective of existential positive psychology, this study explores the posttraumatic growth of travelers from Hubei, China, during the early outbreak period.

LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.

Constitutive activation of the Hedgehog (Hh) signaling pathway has been implicated in the development of many human malignancies. Hh targets, such as Patched (PTCH), smoothened (SMO), Sonic hedgehog (SHH) and glioma-associated oncogene homologue 1 (GLI1), are markers of Hh signaling activation and expressed in most Hh-associated tumors. The protein kinase LKB1 has been shown to slow proliferation and induce cell-cycle arrest in many cell lines.