Identification of the oncogenic role and clinical implication of in Colon Adenocarcinoma.

Colorectal carcinoma (CRC) is a highly prevalent and life-threatening disease with multi-stage progression, characterized by diverse molecular expression patterns at distinct stages, making treatment particularly challenging. Early detection and diagnosis of CRC are vital and can greatly benefit from the discovery of effective biomarkers. Researchers have identified novel gene signatures that play pivotal roles in specific CRC types or stages.

Yinjia pills inhibits the malignant biological behavior of HeLa cells through PKM2-medicated inhibition of JAK/STAT3 pathway.

Cervical cancer is one of the most common tumors in women and is a major problem in gynecological health. Studies have shown that Yinjia pills (YJP), a traditional Chinese medicine, can effectively slow the progression of cervical cancer. Therefore, this study mainly explored the molecular mechanism by which YJP delays the progression of cervical cancer.

A resource of induced pluripotent stem cell (iPSC) lines including clinical, genomic, and cellular data from genetically isolated families with mood and psychotic disorders.

Genome-wide (GWAS) and copy number variant (CNV) association studies have reproducibly identified numerous risk alleles associated with bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ), but biological characterization of these alleles lags gene discovery, owing to the inaccessibility of live human brain cells and inadequate animal models for human psychiatric conditions. Human-derived induced pluripotent stem cells (iPSCs) provide a renewable cellular reagent that can be differentiated into living, disease-relevant cells and 3D brain organoids carrying the full complement of genetic variants present in the donor germline. Experimental studies of iPSC-derived cells allow functional characterization of risk alleles, establishment of causal relationships between genes and neurobiology, and screening for novel therapeutics.

Off-policy two-dimensional reinforcement learning for optimal tracking control of batch processes with network-induced dropout and disturbances.

In this paper, a new off-policy two-dimensional (2D) reinforcement learning approach is proposed to deal with the optimal tracking control (OTC) issue of batch processes with network-induced dropout and disturbances. A dropout 2D augmented Smith predictor is first devised to estimate the present extended state utilizing past data of time and batch orientations. The dropout 2D value function and Q-function are further defined, and their relation is analyzed to meet the optimal performance.

Phenolic Constituents from Black Quinoa Alleviate Insulin Resistance in HepG2 Cells via Regulating IRS1/PI3K/Akt/GLUTs Signaling Pathways.

Quinoa is a nutrient-rich pseudocereal with a lower glycemic index and glycemic load. However, its therapeutic potency and underlying mechanism against insulin resistance (IR) have not been fully elucidated. In this work, network pharmacology was applied to screen IR targets and their related pathways.

Upconverting Nanoparticle-Based Photoactive Probes for Highly Efficient Labeling and Isolation of Target Proteins.

Photoaffinity labeling (PAL) has blossomed into a powerful and versatile tool for capture and identification of biomolecular targets. However, low labeling efficiency for specific targets such as lectins, the tedious process for protein purification, inevitable cellular photodamage, and less tissue penetration of UV light are significant challenges. Herein, we reported a near-infrared (NIR) light-driven photoaffinity labeling approach using upconverting nanoparticle (UCNP)-based photoactive probes, which were constructed by assembling photoactive groups and ligands onto NaYF:Yb,Tm nanoparticles.

increases Prostaglandin E secretion in cow neutrophils by activating TLR2, TLR4, and NLRP3 inflammasome signaling pathways.

Introduction: In clinical settings, dairy cows are often attacked by pathogenic bacteria after delivery, especially (). Neutrophils have long been regarded as essential for host defense against . Prostaglandin E (PGE) can additionally be used as an inflammatory mediator in pathological conditions to promote the repair of inflammatory injuries.

Unveiling alkali metal poisoning of CrMn catalyst for selective catalytic reduction of NO with NH: An experimental and theoretical study.

Alkali metal poisoning has been an intricate and unsolved issue confining the catalytic activity of NH-SCR catalysts up to now. Herein, the effect of NaCl and KCl on catalytic activity of CrMn catalyst for NH-SCR of NO was systematically investigated to clarify the alkali metal poisoning by combined experiments and theoretical calculations. It unveiled that NaCl/KCl could deactivate CrMn catalyst due to the decrease in specific surface area, electron transfer (Cr+Mn↔Cr+Mn), redox ability and oxygen vacancy and NH/NO adsorption.

Dance emotion recognition based on linear predictive Meir frequency cepstrum coefficient and bidirectional long short-term memory from robot environment.

Dance emotion recognition is an important research direction of automatic speech recognition, especially in the robot environment. It is an important research content of dance emotion recognition to extract the features that best represent speech emotion and to construct an acoustic model with strong robustness and generalization. The dance emotion data set is small in size and high in dimension.

Elucidating the facet-dependent reactivity of CrMn catalyst for selective catalytic reduction of NO with NH.

The facet-dependent reactivity of CrMn catalysts was still unclear, hindering the further enhancement of their low-temperature SCR performance. Herein, the facet-dependent reactivity of CrMnO catalyst for NH-SCR of NO was innovatively illustrated by numerous characterizations and density functional theory (DFT) calculations. Exposed (100) facet of CrMnO catalyst exhibited best low-temperature SCR activity with ≥90 % NO conversion within 148-296 °C and 2.

Novel data-driven two-dimensional Q-learning for optimal tracking control of batch process with unknown dynamics.

In view that the previous control methods usually rely too much on the models of batch process and have difficulty in a practical batch process with unknown dynamics, a novel data-driven two-dimensional (2D) off-policy Q-learning approach for optimal tracking control (OTC) is proposed to make the batch process obtain a model-free control law. Firstly, an extended state space equation composing of the state and output error is established for ensuring tracking performance of the designed controller. Secondly, the behavior policy of generating data and the target policy of optimization as well as learning is introduced based on this extended system.

PLS Subspace-Based Calibration Transfer for Near-Infrared Spectroscopy Quantitative Analysis.

In order to enable the calibration model to be effectively transferred among multiple instruments and correct the differences between the spectra measured by different instruments, a new feature transfer model based on partial least squares regression (PLS) subspace (PLSCT) is proposed in this paper. Firstly, the PLS model of the master instrument is built, meanwhile a PLS subspace is constructed by the feature vectors. Then the master spectra and the slave spectra are projected into the PLS subspace, and the features of the spectra are also extracted at the same time.

Sodium valproate rescues expression of TRANK1 in iPSC-derived neural cells that carry a genetic variant associated with serious mental illness.

Biological characterization of genetic variants identified in genome-wide association studies (GWAS) remains a substantial challenge. Here we used human-induced pluripotent stem cells (iPSC) and their neural derivatives to characterize common variants on chromosome 3p22 that have been associated by GWAS with major mental illnesses. IPSC-derived neural progenitor cells carrying the risk allele of the single nucleotide polymorphism (SNP), rs9834970, displayed lower baseline TRANK1 expression that was rescued by chronic treatment with therapeutic dosages of valproic acid (VPA).

Effects of dietary methionine on breast muscle growth, myogenic gene expression and IGF-I signaling in fast- and slow-growing broilers.

This study investigated the responses of fast- (FG) and slow- (SG) growing broilers to dietary methionine (Met) status. The broilers were subjected to low (LM, 0.38 and 0.

Chronic Opioid Usage in Surgical Patients in a Large Academic Center.

Objective: The objective of this study is to investigate the prevalence and disparity of chronic opioid usage in surgical patients and the potential risk factors associated with chronic opioid usage.

Background: Chronic opioid usage is common in surgical patients; however, the characteristics of opioid usage in surgical patients is unclear. In this study, we hypothesize that the prevalence of chronic opioid usage in surgical patients is high, and that significant disparities may exist among different surgical populations.

The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect.

Multi-target drugs, such as the cocktail therapy used for treating AIDS, often show stronger efficacy than single-target drugs in treating complicated diseases. This review will focus on clausenamide (clau), a small molecule compound originally isolated from the traditional Chinese herbal medicine, Clausenalansium. The finding of four chiral centers in clau molecules predicted the presence of 16 clau enantiomers, including (-)-clau and (+)-clau.

[Open construction of experimental abdominal aortic aneurysm swine models with Dacron patch for evaluating endovascular aneurysm repair techniques].

Objective: To construct an experimental abdominal aortic aneurysm (AAA) swine model with Dacron patch for evaluating endovascular aneurysm repair (EVAR) technique.

Methods: The experimental pigs were generally anesthetized for the open procedure of an aneurysm model creation with Dacron and subsequent arteriography and EVAR with stent graft. Repeat arteriography was performed after 3-month follow-up.

D-π-A-π-D type benzothiadiazole-triphenylamine based small molecules containing cyano on the π-bridge for solution-processed organic solar cells with high open-circuit voltage.

Two novel D-π-A-π-D structured small molecules composed of benzothiadiazole and triphenylamine were designed and synthesized. with cyano on the π-bridge exhibited a deep HOMO energy level, resulting in an impressive V(OC) of up to 1.04 V with a PCE of 3.

Protein kinase C acts as a molecular detector of firing patterns to mediate sensory gating in Aplysia.

Habituation of a behavioral response to a repetitive stimulus enables animals to ignore irrelevant stimuli and focus on behaviorally important events. In Aplysia, habituation is mediated by rapid depression of sensory synapses, which could leave an animal unresponsive to important repetitive stimuli, making it vulnerable to injury. We identified a form of plasticity that prevents synaptic depression depending on the precise stimulus strength.

Endovascular repair of aortoiliac aneurysm with a hybrid technique to preserve pelvic perfusion.

Endovascular aneurysm repair (EVAR) has been proven to be an effective and safe technique for abdominal or iliac artery aneurysm. However, for aneurysms extending to both iliac bifurcations, routine EVAR will occlude both internal iliac arteries (IIAs), which may increase the risk for pelvic ischemia. New endovascular techniques have been developed to preserve the pelvic perfusion in EVAR for such situation.

[Premedication with oral midazolam in children receive sevoflurane general anesthesia].

Objective: To investigate the effect of oral midazolam on sedation, on perioperative emotion and on behavior in children with sevoflurane general anesthesia.

Methods: 48 children undergoing cataract surgeries were randomly divided into two groups and respectively received 0.5 mg/kg oral midazolam (Group I)and placebo (Group II) 30 minutes before the operation.

Successful repair for a ruptured venous aneurysm: an unusual complication of venous arterialization in Buerger's disease.

We report a ruptured venous aneurysm, an unusual complication of venous arterialization for lower limb ischemia in Buerger's disease. Arteriovenous shunt ligation and aneurysm resection were performed successfully, with the distal limb perfusion preserved. By our very limited experience, venous arterialization may be ineffective on improving lower limb ischemia with Buerger's disease.

Lower extremity arterial occlusive disease as a rare complication of Crohn's disease.

Objective: To investigate the clinical characteristics and treatment strategy of lower extremity arterial occlusive disease in patients with Crohn's disease (CD).

Methods: Clinical information of 9 cases suffering from lower extremity arterial occlusion and CD was investigated retrospectively.

Results: All the cases were less than 50 years old and the most were females (8/9).