Publications by authors named "Xueyao Lu"

Maize (Zea mays) is the most widely cultivated crop in the world. Maize production is closely linked to the extensive uptake and utilization of various mineral nutrients. Potassium (K), calcium (Ca), and magnesium (Mg) are essential metallic macronutrients for plant growth and development.

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Sakuranetin, a flavonoid phytoalexin, has demonstrated neuroprotective properties and exhibits tyrosinase inhibitory activities, making it highly valuable in the cosmetics and pharmaceutical industries. In this study, we engineered a strain for the high-titer de novo production of sakuranetin using glucose as a substrate. To effectively enhance sakuranetin production, we implemented a multimodule engineering strategy that included optimizing the sakuranetin synthesis pathway, designing a regeneration system for the methyl donor S-adenosyl methionine, increasing the malonyl-CoA precursor supplement, and constructing the feedback inhibition-relieved shikimate pathway.

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Article Synopsis
  • The study investigates the brain mechanisms involved in non-syndromic congenital mirror movements (CMM), suggesting that abnormal brain connectivity, particularly between the supplementary motor area (SMA) and motor cortex (M1), contributes to these movements.* -
  • Twelve individuals with CMM were tested alongside a control group in a Go-NoGo task, using EEG to analyze differences in readiness for voluntary hand movements and brain connectivity.* -
  • Results indicated that individuals with CMM had delayed movement readiness and increased connectivity in specific brain regions, hinting at possible neurocompensatory adaptations due to lifelong mirroring experiences.*
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Gastrodin, a phenolic glycoside, is a prominent component of Gastrodia elata, which is renowned for its sedative, hypnotic, anticonvulsant, and neuroprotective activities. Engineering heterologous production of plant natural products in microbial host represents a safe, cost-effective, and scalable alternative to plant extraction. Here, we present the construction of an engineered Yarrowia lipolytica yeast that achieves a high-titer production of gastrodin.

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