Publications by authors named "Xueyao Fang"
Article Synopsis
- - The study compares the effectiveness of three blood culture media (BACT/ALERT FA/FN Plus from France, DL from China, and REDOX from the USA) in recovering microorganisms from blood samples containing antimicrobials, revealing that BACT/ALERT significantly outperformed the other two in both aerobic and anaerobic conditions.
- - Recovery rates for the media showed BACT/ALERT with 87.5% and 91.4% recovery in aerobic and anaerobic conditions, respectively, while DL and REDOX showed much lower rates, especially under anaerobic conditions (2.9% for DL and 14.3% for REDOX).
- - The study highlights the need for improved neutralization
Staphylococcus aureus is a common pathogen capable of infecting both humans and animals and causing various severe diseases. Here, we aimed to determine the biological features and pathogenicity of S. aureus strain Sa9, of the incomplete hemolysis phenotype, isolated from bovine milk.
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- The study looked at two types of treatments for people with a serious infection caused by superbugs at a Chinese hospital.
- It found that patients treated with newer medications (CPT) were in worse overall health but had better recovery rates compared to those receiving traditional treatments (CT).
- Additionally, cold weather was linked to higher chances of dying within 30 days, while the infection was more common in hot weather, suggesting more research is needed.
Article Synopsis
- The study aimed to identify clinical features, risk factors, and effective treatments for Carbapenem-resistant Acinetobacter baumannii (CRAB) bloodstream infections (BSI) based on data from a Chinese hospital.
- Among 276 patients, 157 had CRAB BSI, with key risk factors including ICU stays, immunocompromised status, and certain antibiotic use.
- The 30-day mortality rate for CRAB BSI was nearly 50%, with cefoperazone/sulbactam treatment showing a significant reduction in mortality compared to other antibiotic strategies.
Background: Carbapenemase-producing is an unprecedented threat to public health, and its detection remains challenging. Analysis of microbial volatile organic compounds (VOCs) may offer a rapid way to determine bacterial antibiotic susceptibility.
Purpose: The aim of this study was to explore the VOCs released by carbapenemase-producing carbapenem-resistant (CRKP) using headspace solid-phase microextraction/gas chromatography-mass spectrometry (HS-SPME/GC-MS).
Article Synopsis
- * Whole-genome sequencing revealed distinct genetic profiles, identifying 20 types of MRSA, with ST59 being the most prevalent, while ST188 and ST7 were predominant in MSSA.
- * The findings indicate that MSSA carries a variety of virulence factors, highlighting the need for increased focus on MSSA infections, and future research should explore the co-evolution of both strains to better understand their interactions.
Article Synopsis
- Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, particularly ESBL-producing E. coli and Klebsiella pneumoniae, pose serious public health challenges as they cause nonurinary source bloodstream infections (BSIs).
- A study of 180 hospitalized patients over four years compared clinical outcomes of those treated with β-lactam/β-lactamase inhibitor combinations (BLICs) versus carbapenem therapies, focusing on treatment failure and mortality rates.
- Results showed no significant difference in 14-day treatment failure and 30-day mortality rates between BLICs and carbapenem treatments, even after adjusting for patient characteristics through propensity score matching.
Article Synopsis
- Polymyxin resistance in gram-negative bacilli, driven by plasmid-mediated genes, is a serious health concern, with coexisting β-lactamase genes observed in some bacterial strains.* -
- In a study involving 107 isolates from a hospital in Jiangxi, China, 14% were found resistant to polymyxin B, all carrying extended-spectrum β-lactamase genes.* -
- The study identified a unique strain (ST485) that harbored multiple resistance genes across three plasmids, raising concerns about the potential spread of these resistance traits.*
Objectives: We aimed to determine the clinical impact of inappropriate empirical antibiotic treatment (IEAT) compared with appropriate empirical antibiotic treatment (AEAT) in hospitalised patients with urinary tract infections (UTIs) caused by Escherichia coli (E. coli).
Methods: This retrospective cohort study included adult patients with a primary diagnosis of UTI who were treated with empirical antibiotics at a tertiary hospital in southern China over a 2-year period.
Objective: The present study assessed risk factors and patient outcomes of bloodstream infection (BSI) caused by extended-spectrum β-lactamase (ESBL)-producing ().
Methods: A retrospective study was performed to analyze risk factors and patient outcomes of BSI caused by extended-spectrum β-lactamase-producing (ESBL-EC) in one Chinese tertiary hospital over a 7.5-year period.
Article Synopsis
- * A study of 41 patients in Nanchang, China, between February and March 2020 revealed that most had close contact with confirmed cases and exhibited common symptoms like fever and cough, with a median age of 39.9 years.
- * All patients recovered, but findings indicated high levels of certain cytokines and other abnormal laboratory results, suggesting the need for monitoring these biochemical markers in patients with mild symptoms.
Article Synopsis
- PJP has become a significant issue in HIV-negative patients, particularly due to increased use of immunosuppressants, with a study involving 96 hospitalized patients in Southern China.
- The majority of cases were found in middle-aged men, with kidney and connective tissue diseases being major risk factors; most patients had recent low-dose immunosuppressive treatments and none had prophylaxis with TMP-SMX.
- Clinical symptoms often included cough, dyspnea, fever, and chest pain, with over 90% showing elevated levels in key biochemical tests, suggesting the need for better early diagnosis and treatment strategies to enhance survival rates.
Rationale: Bacteremia caused by polymicrobial infections are rare but dangerous. We report a case of hepatic abscess combined with polymicrobial bacteremia in a 49-year-old male patient after surgery and transcatheter arterial chemoembolization (TACE).
Patient Concerns: The patient was admitted to hospital with metastatic liver cancer for periodic chemotherapy and developed a high fever and tenderness to the liver following surgery and TACE.
Escherichia coli is an important pathogen of nosocomial infection in clinical research, Thus, exploring new methods for the rapid detection of this pathogen is urgent. We reported the early release of molecular volatile indole vapour of E. coli cultures and blood cultures analyzed by direct atmospheric corona discharge ionization mass spectrometry (CDI-MS).
View Article and Find Full Text PDFPurpose: The aim of the present study was to investigate the dissemination of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates in integrated intensive care units (IICUs) and emergency ICUs (EICUs) for controlling the spread of CRKP in different ICUs of the hospital.
Methodology: From January 2016 to April 2017, a total of 46 non-duplicate CRKP isolates were consecutively isolated from a tertiary hospital. The production of carbapenemases was determined by the modified carbapenem inactivation method (mCIM) test.