High-fidelity digital-analog hybrid RoF fronthaul link enabled by nonlinear radio signal shaping.

We propose a simple and effective method to enhance the fidelity of radio signals in a digital-analog radio-over-fiber (DA-RoF) system by introducing nonlinearity into the transmitted signal. This nonlinearity is introduced via an arctangent function for radio signal shaping (RSS), while the corresponding tangent function is used for signal recovery. Nonlinear shaping spreads near-zero amplitude signals and compresses far-from-zero ones.

Colloidal quantum dots enable tunable liquid-state lasers.

Present-day liquid-state lasers are based on organic dyes. Here we demonstrate an alternative class of liquid lasers that use solutions of colloidal quantum dots (QDs). Previous efforts to realize such devices have been hampered by the fast non-radiative Auger recombination of multicarrier states required for optical gain.

Safety and efficacy of the amino acid crosslinked hyaluronic acid in the treatment of temple hollowing.

Background: Loss of volume in the temples is an early sign of aging and often gives the impression of a gaunt and emaciated appearance.

Objective: The authors conduct a clinical study to investigate the safety and effectiveness of the amino acid crosslinked hyaluronic acid (ACHA) for the treatment of temple hollowing.

Methods: 75 subjects with Temple Hollowing Scale (THS) from 2 to 4 were enrolled and assigned according to the ratio of 2 (ACHA group, n = 50): 1 (no treatment control group, n = 25).

Blue lasers using low-toxicity colloidal quantum dots.

Blue lasers play a pivotal role in laser-based display, printing, manufacturing, data recording and medical technologies. Colloidal quantum dots (QDs) are solution-grown materials with strong, tunable emission covering the whole visible spectrum, but the development of QD lasers has largely relied on Cd-containing red-emitting QDs, with technologically viable blue QD lasers remaining out of reach. Here we report on the realization of tunable and robust lasing using low-toxicity blue-emitting ZnSe-ZnS core-shell QDs that are compact in size yet still feature suppressed Auger recombination and long optical gain lifetime approaching 1 ns.

KLF15 suppresses stemness of pancreatic cancer by decreasing USP21-mediated Nanog stability.

The existence of cancer stem cells (CSCs) in pancreatic ductal adenocarcinoma (PDAC) is considered to be the key factor for metastasis and chemoresistance. Thus, novel therapeutic strategies for eradicating CSCs are urgently needed. Here we aimed to explore the role of KLF15 in stemness and the feasibility of using KLF15 to inhibit CSCs and improve chemotherapy sensitivity in PDAC.

CD64 fibroblast-targeted vilanterol and a STING agonist augment CLDN18.2 BiTEs efficacy against pancreatic cancer by reducing desmoplasia and enriching stem-like CD8 T cells.

Objective: The objective of this study is to improve the efficacy of CLDN18.2/CD3 bispecific T-cell engagers (BiTEs) as a promising immunotherapy against pancreatic ductal adenocarcinoma (PDAC).

Design: Humanised hCD34/hCD3e, Trp53KrasPdx1-Cre (KPC), pancreas-specific Cldn18.

Physical exercise for brain plasticity promotion an overview of the underlying oscillatory mechanism.

The global recognition of the importance of physical exercise (PE) for human health has resulted in increased research on its effects on cortical activity. Neural oscillations, which are prominent features of brain activity, serve as crucial indicators for studying the effects of PE on brain function. Existing studies support the idea that PE modifies various types of neural oscillations.

Effects of ultrasound-guided thoracolumbar interfascial plane block combined with general anaesthesia versus general anaesthesia alone on emergence agitation in children with cerebral palsy undergoing selective posterior rhizotomy: protocol for a randomised controlled clinical trial.

Introduction: Selective posterior rhizotomy (SPR) is a preferred procedure for relieving spastic children with cerebral palsy, but it is associated with severe pain and significant emergence agitation (EA). The thoracolumbar interfascial plane (TLIP) block provides an effective blockade to the dorsal branch of the spinal nerve. We hypothesise that the TLIP block may be an effective tool to alleviate EA and postoperative pain scores in children with cerebral palsy undergoing SPR.

Ultrathin 2D/2D ZnInS/LaTiO nanosheets with a Z-scheme heterojunction for enhanced photocatalytic hydrogen evolution.

Layered lanthanum titanate (LaTiO) perovskite is a good photocatalytic material owing to its high stability, strong redox ability, and non-toxicity. However, its inherent wide bandgap limits its application in photocatalytic hydrogen evolution. Therefore, combining LaTiO with two-dimensional (2D) narrow-bandgap semiconductors to form 2D/2D layered structures is the preferred strategy to improve its photocatalytic performance.

Development of Negative-Temperature Cement Emulsified Asphalt Spraying Materials Based on Spraying Performance and Rheological Parameters.

To develop a cement emulsified asphalt composite (CEAC) that can be sprayed under a plateau negative temperature environment, the effects of the water-solid ratio, calcium aluminate cement substitution rate, emulsified asphalt content, sand-binder ratio, and polyvinyl alcohol (PVA) fiber content on the spraying performance and rheological parameters of CEAC were explored through the controlled variable method. Additionally, the correlation between the spraying performance and rheological parameters of CEAC was established, and the optimal proportion of CEAC was determined. Then, the difference in frost resistance and pore structure between the cement slurry (CS) without emulsified asphalt and CEAC at the optimum proportion was analyzed.

Layer-by-Layer Construction of Antibacterial and Anticoagulant Blood Contacting Materials.

Vascular transplantation is a common treatment for Cardiovascular disease (CVD). However, the mismatch of mechanical, structural, or microenvironmental properties of materials limits the clinical application. Therefore, the functional construction of artificial vessels or other blood contact materials remains an urgent challenge.

Comparative transcriptomic analysis reveals the molecular changes of acute pancreatitis in experimental models.

Background: Acute pancreatitis (AP) encompasses a spectrum of pancreatic inflammatory conditions, ranging from mild inflammation to severe pancreatic necrosis and multisystem organ failure. Given the challenges associated with obtaining human pancreatic samples, research on AP predominantly relies on animal models. In this study, we aimed to elucidate the fundamental molecular mechanisms underlying AP using various AP models.

Targeting ESE3/EHF With Nifurtimox Inhibits CXCR2 Neutrophil Infiltration and Overcomes Pancreatic Cancer Resistance to Chemotherapy and Immunotherapy.

Background & Aims: Because pancreatic cancer responds poorly to chemotherapy and immunotherapy, it is necessary to identify novel targets and compounds to overcome resistance to treatment.

Methods: This study analyzed genomic single nucleotide polymorphism sequencing, single-cell RNA sequencing, and spatial transcriptomics. Ehf-knockout mice, KPC (LSL-Kras, LSL-Trp53 and Pdx1-Cre) mice, CD45.

A universal design of restructured dimer antigens: Development of a superior vaccine against the paramyxovirus in transgenic rice.

The development of vaccines, which induce effective immune responses while ensuring safety and affordability, remains a substantial challenge. In this study, we proposed a vaccine model of a restructured "head-to-tail" dimer to efficiently stimulate B cell response. We also demonstrate the feasibility of using this model to develop a paramyxovirus vaccine through a low-cost rice endosperm expression system.

Two-Color Amplified Spontaneous Emission from Auger-Suppressed Quantum Dots in Liquids.

Colloidal quantum-dot (QD) lasing is normally achieved in close-packed solid-state films, as a high QD volume fraction is required for stimulated emission to outcompete fast Auger decay of optical-gain-active multiexciton states. Here a new type of liquid optical-gain medium is demonstrated, in which compact compositionally-graded QDs (ccg-QDs) that feature strong suppression of Auger decay are liquefied using a small amount of solvent. Transient absorption measurements of ccg-QD liquid suspensions reveal broad-band optical gain spanning a wide spectral range from 560 (green) to 675 nm (red).

Acetamide-Caprolactam Deep Eutectic Solvent-Based Electrolyte for Stable Zn-Metal Batteries.

Aqueous Zn-ion batteries (AZIBs) are promising for grid-scale energy storage. However, conventional AZIBs face challenges including hydrogen evolution reaction (HER), leading to high local pH, and by-product formation on the anode. Hereby the hydrogen bonds in the aqueous electrolyte are reconstructed by using a deep eutectic co-solvent (DES) made of acetamide (H-bond donor) and caprolactam (H-bond acceptor), which effectively suppresses the reactivity of water and broadens the electrochemical voltage stability window.

Rice-produced classical swine fever virus glycoprotein E2 with herringbone-dimer design to enhance immune responses.

Pestiviruses, including classical swine fever virus, remain a concern for global animal health and are responsible for major economic losses of livestock worldwide. Despite high levels of vaccination, currently available commercial vaccines are limited by safety concerns, moderate efficacy, and required high doses. The development of new vaccines is therefore essential.

Realistic Spin Model for Multiferroic NiI_{2}.

A realistic first-principle-based spin Hamiltonian is constructed for the type-II multiferroic NiI_{2}, using a symmetry-adapted cluster expansion method. Besides single ion anisotropy and isotropic Heisenberg terms, this model further includes the Kitaev interaction and a biquadratic term, and can well reproduce striking features of the experimental helical ground state, that are, e.g.

An efficient numerical method on modified space-time sparse grid for time-fractional diffusion equation with nonsmooth data.

In this paper, we focus on developing a high efficient algorithm for solving -dimension time-fractional diffusion equation (TFDE). For TFDE, the initial function or source term is usually not smooth, which can lead to the low regularity of exact solution. And such low regularity has a marked impact on the convergence rate of numerical method.

Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis.

Background: Chemoresistance is the main reason for the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Thus, there is an urgent need to screen out new targets and compounds to reverse chemotherapeutic resistance.

Methods: We established a bio-bank of human PDAC organoid models, covering a representative range of PDAC tumor subtypes.

Functionalization of PCL-based nanofibers loaded with hirudin as blood contact materials.

Blood-contacting materials with good mechanical property, excellent anticoagulant function and promoting effect on endothelialization are in great demand for clinical application such as vascular grafts in treating cardiovascular diseases. In this study, electrospinning nanofiber scaffolds of polycaprolactone (PCL) were functionalized by oxidative self-polymerization of dopamine (PDA) on the surface followed by the modification of anticoagulant recombinant hirudin (rH) molecules. The morphology, structure, mechanical property, degradation behavior, cellular compatibility and blood compatibility of the multifunctional PCL/PDA/rH nanofiber scaffolds were evaluated.

Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma.

Objective: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy. CD8 T cells, cancer stem cells (CSCs), and tumor budding (TB) have been significantly correlated with the outcome of patients with PDAC, but the correlations have been independently reported. In addition, no integrated immune-CSC-TB profile for predicting survival in patients with PDAC has been established.