Schisanhenol Inhibits the Proliferation of Hepatocellular Carcinoma Cells by Targeting Programmed Cell Death-ligand 1 via the STAT3 Pathways.

Background: Programmed cell death-ligand 1 (PD-L1) is overexpressed in tumor cells, which promotes tumor cell survival and cell proliferation and causes tumor cells to escape T-cell killing. Schisanhenol, a biphenyl cyclooctene lignin-like compound, was extracted and isolated from the plant named Schisandra rubriflora (Franch.).

Efficacy and safety of pegylated liposomal doxorubicin and epirubicin as neoadjuvant chemotherapy for breast cancer.

Aim: This study aims to compare the efficiencies and toxicities of pegylated liposomal doxorubicin (PLD) based and epirubicin based chemotherapeutic regimens as neoadjuvant chemotherapy (NAC) for early breast cancer.

Patients And Methods: We retrospectively analyzed 391 patients with stage II-III breast cancer who received NAC in multiple centers. The efficiencies and toxicities of PLD and epirubicin based NAC regimens were compared by using both propensity-score matched (PSM) and unmatched data.

Critical evaluation of extracellular polymeric substances extraction methods: Extraction efficiency, molecular characteristics, and heavy metals binding properties.

Extracellular polymeric substances (EPS) significantly influence the properties and performance of waste activated sludge. Various pretreatment protocols with different extraction efficiency and characteristics of EPS have been reported, which markedly impact subsequent treatment and disposal of sewage sludge. This study systematically assesses the EPS properties from twelve extraction pretreatment methods.

Facile Synthesis of Cu-Exchanged Zeolite Catalysts with Only Cu-2Z Species: Enhancing Hydrothermal Stability and Sulfur Resistance for NH-SCR.

For Cu-exchanged zeolite catalysts, Cu ions existing as Cu-2Z and [Cu(OH)]-Z (where Z represents a framework negative charge) are considered the active sites for the selective catalytic reduction of NO with NH (NH-SCR). Cu-2Z is more hydrothermally stable and sulfur poisoning-resistant than [Cu(OH)]-Z. In this work, Cu-CHA and Cu-LTA catalysts containing only Cu-2Z species were successfully synthesized by a novel impregnation (NIM) method, exhibiting remarkably enhanced hydrothermal stability and sulfur resistance compared with any reported Cu-exchanged zeolite catalysts.

Expression changes of ER, PR, HER2, and Ki-67 in primary and metastatic breast cancer and its clinical significance.

Objective: To explore the altered expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and cell proliferation index (Ki-67) in primary and metastatic breast cancer lesions and the correlation between the primary tumor size, lymph node metastasis, Tumor Node Metastasis (TNM) stage, molecular typing, and disease-free survival (DFS) and their clinical significance.

Methods: A retrospective analysis was conducted on the clinical data of 130 patients with metastatic breast cancer biopsy admitted to the Cancer Center of the Second Affiliated Hospital of Anhui Medical University in Hefei, China, from 2014-2019. The altered expression of ER, PR, HER2, and Ki-67 in primary and metastatic lesions of breast cancer was analyzed with respect to the site of metastasis, size of the primary tumor, lymph node metastasis, disease progression, and prognosis.

Improvement of coal gasification reverse osmosis concentrate treatment by Cu-Co-Mn/AC catalytic ozonation.

Approximately 20% of concentrate will be produced from coal gasification wastewater after reverse osmosis treatment. The organic matter contained in the concentrate affects its evaporation crystallisation; therefore, the refractory organics must be removed. In this study, Cu-Co-Mn/AC catalytic ozonation was used to treat reverse osmosis concentrate (ROC).

Effects of different concentrations of CO on Scenedesmus obliquus to overcome sludge extract toxicity and accumulate biomass.

Large amounts of toxic excess sludge as well as high concentrations of carbon dioxide can be produced in coal-gasification industry. Microalgae has huge potential in the use of nutrients, the removal of toxic organic matter in excess sludge and CO fixation. At the same time, the cultivation of the microalgae and the accumulation of high-quality biomass are also the key problems of concern.

Anlotinib plus nab-paclitaxel/gemcitabine as first-line treatment prolongs survival in patients with unresectable or metastatic pancreatic adenocarcinoma: a retrospective cohort.

Background: The timely addition of anlotinib to the nab-paclitaxel/gemcitabine regimen may further increase the treatment efficacy for pancreatic adenocarcinoma (PDAC), which has not yet been reported. Therefore, we aimed to compare the efficacy and safety of anlotinib plus nab-paclitaxel/gemcitabine in the first-line treatment of patients with unresectable or metastatic PDAC.

Methods: This was a retrospective cohort of patients with unresectable or metastatic PDAC performed in The First Affiliated Hospital of Anhui Medical University from August 17, 2019 to April 3, 2021.

Safety and efficacy of sintilimab combination therapy for the treatment of 48 patients with advanced malignant tumors.

Background: Sintilimab is a recombinant fully human anti-programmed death 1 (PD-1) monoclonal antibody that blocks the interaction of PD-1 with its ligand. We evaluated the safety and efficacy of sintilimab combined with chemotherapy and targeted therapy in the treatment of advanced malignant tumors.

Methods: We performed a retrospective analysis of the clinical data of patients with advanced malignant tumors treated with sintilimab combined with chemotherapy and targeted therapy admitted to the Third Ward of the Department of Medical Oncology, First Affiliated Hospital of Anhui Medical University, China, from July 2019 to February 2021.

Bacterial diversity evolution process based on physicochemical characteristics of sludge treating hydroquinone during acclimation.

Hydroquinone is one of the main pollutants in coal-gasification wastewater, which is biologically toxic and difficult to remove. The aerobic biodegradation rate, organic toxicity, and microbial community structure at different acclimation stages of degradation of hydroquinone by activated sludge were investigated. In each acclimation cycle, the removal of hydroquinone reached 100% after 5 days, indicating that high-concentration hydroquinone in the activated sludge could be completely biodegraded.

Study on the differences in sludge toxicity and microbial community structure caused by catechol, resorcinol and hydroquinone with metagenomic analysis.

The aerobic biodegradation rate, organic toxicity and microbial community structure of activated sludge acclimated by catechol, resorcinol and hydroquinone were investigated, to study the relationship between microbial structure and sludge organic toxicity caused by phenolic compounds. At the stable operation stage, the degradation rates of the dihydroxy benzenes in a single sequencing batch reactor (SBR) cycle were followed the order: resorcinol (89.71%) > hydroquinone (85.

IoT Adaptive Dynamic Blockchain Networking Method Based on Discrete Heartbeat Signals.

The combination of blockchain technology and Internet of Things (IoT) technology has brought many significant advantages and new development directions. With the development of embedded technology and 5G communication technology, the performance limitations and network limitations that are traditionally believed to restrict the application of blockchain technology to IoT devices have been broken. The development of "blockchain + 5G + IoT" provides reliable data from the source for the blockchain, linking the credible mapping of physical assets and digital assets.

Design and Test of a Microdestructive Tree-Ring Measurement System.

Analysis of a tree ring is the primary method for determining the growth and age of a tree. In a microdestructive tree-ring measurement system, the tree under test is drilled with a microdrill at a constant rotating speed to detect the difference in density between the early and late wood, thereby realizing a microdestructive measurement of the tree-ring. The measurement system comprises a microdrill with a diameter of 3 mm, mechanical transmission, direct current (DC) servomotor, stepper motor, and control and detection circuit.

Clinical efficacy analysis of Osimertinib treatment for a patient with leptomeningeal metastasis of EGFR+ non-small cell lung cancer without the T790M mutation.

Background: To find the method of therapy of leptomeningeal metastasis (LM) to non-small cell lung cancer (NSCLC) patient with EGFR mutation (EGFR+) but without T790M mutation.

Methods: A retrospective analysis was reviewed for 5 NSCLC patients with EGFR+ who develop to LM from January 2018 to February 2019 in our hospital.

Results: All five NSCLC cases were adenocarcinoma, four cases were verified existed EGFR mutation with 19 exon deletion in the first diagnosed by biopsy tissue, the other tissue was verified 21 exon mutation.

A significant carbon sink in temperate forests in Beijing: based on 20-year field measurements in three stands.

Numerous efforts have been made to characterize forest carbon (C) cycles and stocks in various ecosystems. However, long-term observation on each component of the forest C cycle is still lacking. We measured C stocks and fluxes in three permanent temperate forest plots (birch, oak and pine forest) during 2011–2014, and calculated the changes of the components of the C cycle related to the measurements during 1992–1994 at Mt.