PXDN as a pan-cancer biomarker and promotes tumor progress via immune inhibition in nasopharyngeal carcinoma.

Background: Investigating oncogenes and the mechanisms driving oncogenic processes in human tumors is imperative for the development of efficient therapies. Peroxidasin (PXDN) has been reported to play a critical role in tissue development and homeostasis. However, the role of PXDN in the occurrence and development of Nasopharyngeal Carcinoma (NPC) remains unknown.

Screening and validation of differentially expressed genes in adipose tissue of patients with obesity and type 2 diabetes mellitus.

White adipose tissue (WAT) plays a pivotal role in the onset of type 2 diabetes mellitus (T2DM) and obesity. Despite its significance the underlying pathogenesis and key genes associated with it remain elusive. In our study, we screened the differentially expressed genes (DEGs) in intra-abdominal WAT of T2DM patients with obesity, as well as those with simple obesity, aiming to lay a foundational theory for an in-depth investigation of T2DM pathogenesis and the identification of novel therapeutic targets.

Downregulation of estrogen receptor-α36 expression attenuates metastasis of hepatocellular carcinoma cells.

This study aimed to examine the role of estrogen receptor (ER)-α36 in the metastasis of hepatocellular carcinoma (HCC) and in the epithelial-mesenchymal transition (EMT). HCC HepG2 and Huh7 cells with the knocked-down level of ER-α36 expression were established. Cell growth and migration of the HepG2 and Huh7 cell variants were studied using MTS, transwell, and wound-healing assays, and the metastatic abilities of HepG2 cell variants were examined using a tail-vein injection model in nude mice.

Clogging and Water Quality Change Effects of Typical Metal Pollutants under Intermittent Managed Aquifer Recharge Using Urban Stormwater.

Managed aquifer recharge (MAR) using urban stormwater facilitates relieving water supply pressure, restoring the ecological environment, and developing sustainable water resources. However, compared to conventional water sources, such as river water and lake water, MAR using urban stormwater is a typically intermittent recharge mode. In order to study the clogging and water quality change effects of Fe, Zn, and Pb, the typical mental pollutants in urban stormwater, a series of intermittent MAR column experiments were performed.

Analysis of Potential Risks Associated with Urban Stormwater Quality for Managed Aquifer Recharge.

Managed aquifer recharge (MAR) can be used to increase storage and availability of groundwater resources, but water resources available for recharge are constrained due to a surface water shortage. Alternative resources, like stormwater, are receiving increasing attention as sustainable resources for reuse in MAR. However, pollutants in stormwater can impact groundwater quality, and cause clogging of the infiltration system.

Mechanism of Suspended Kaolinite Particle Clogging in Porous Media During Managed Aquifer Recharge.

Managed aquifer recharge is an effective strategy for urban stormwater management. Chemical ions are normally retained in stormwater and groundwater and may accelerate clogging during the recharge process. However, the effect of water chemistry on physical clogging has not previously been investigated.

[Research Progress on the Sources of Inorganic Nitrogen Pollution in Groundwater and Identification Methods].

The identification of the main inorganic nitrogen (MIN, referring to NH-N, NO-N, and NO-N) pollution sources in groundwater is of great significance to its control and repair. A review of the MIN sources in groundwater and the main identification methods was conducted. The main sources of MIN pollution in groundwater (atmospheric nitrogen deposition, soil natural organic nitrogen mineralization, nitrogen from streams, and nitrogen emission from human activity), and its distribution in China were expounded.

Identification of key influence factors and an empirical formula for spring snowmelt-runoff: A case study in mid-temperate zone of northeast China.

Because of the unique climate characteristics, the runoff law in mid-temperate zone is very different from other regions in spring. Accurate runoff simulation and forecasting is of great importance to spring flood control and efficient use of water resources. Baishan reservoir is located in the upper Second Songhua River Basin in Northeast China, where snowmelt is an important source of runoff that contributes to the water supply.

Unraveling the complexities of the velocity dependency of E. coli retention and release parameters in saturated porous media.

Escherichia coli transport and release experiments were conducted to investigate the pore-water velocity (v) dependency of the sticking efficiency (α), the fraction of the solid surface area that contributed to retention (S), the percentage of injected cells that were irreversibly retained (M), and cell release under different (10-300mM) ionic strength (IS) conditions. Values of α, S, and M increased with increasing IS and decreasing v, but the dependency on v was greatest at intermediate IS (30 and 50mM). Following the retention phase, successive increases in v up to 100 or 150mday and flow interruption of 24h produced negligible amounts of cell release.

Surface clogging process modeling of suspended solids during urban stormwater aquifer recharge.

Aquifer recharge, which uses urban stormwater, is an effective technique to control the negative effects of groundwater over-exploitation, while clogging problems in infiltration systems remain the key restricting factor in broadening its practice. Quantitative understanding of the clogging process is still very poor. A laboratory study was conducted to understand surface physical clogging processes, with the primary aim of developing a model for predicting suspended solid clogging processes before aquifer recharge projects start.