Publications by authors named "Xueyan Lu"
Article Synopsis
- High serum estrogen levels after controlled ovarian hyperstimulation (COH) are linked to pregnancy complications due to issues with uterine natural killer (uNK) cells, which are vital for healthy pregnancy and placentation.
- The study utilized various laboratory techniques, including flow cytometry and qRT-PCR, to analyze the effects of high estrogen on the function of uNK cells and related cytokines.
- Results revealed that elevated estrogen suppresses IL-11 expression in decidual stromal cells, leading to decreased levels of important pro-angiogenic factors like VEGF and PLGF in uNK cells, providing insight into the complications following COH.*
Article Synopsis
- A study focused on assessing the relationship between visceral fat area (VFA) and metabolic syndrome (MetS) in patients with ischemic stroke, revealing a significant prevalence of MetS at 43.4%.
- The research involved 851 stroke patients, measuring VFA with specialized methods and employing statistical analysis to identify key risk factors for MetS.
- Results indicated that factors like female gender, visceral obesity, and higher body mass index significantly elevated MetS risk, with specific VFA cut-off values established for men and women to help predict MetS occurrence.
Article Synopsis
- The study investigates the role of decidual natural killer (dNK) cells and their elevated levels of IFN-γ in recurrent pregnancy loss (RPL), aiming to understand how exosomes from induced abortion and RPL patients impact these cells.* -
- Researchers employed methods like flow cytometry and RT-qPCR to analyze the effects of villus-derived exosomes (vEXOs) on dNK cells, focusing on the regulation of IFN-γ levels and identifying therapeutic candidates through miRNA analysis.* -
- Results showed higher IFN-γ in dNK cells from unexplained RPL patients compared to induced abortion patients, indicating that both types of vEXOs could be taken up by dNK cells, with implications
Article Synopsis
- Intrauterine adhesion (IUA) leads to the formation of scar tissue in the uterus, negatively affecting reproductive health and causing infertility, with limited treatment options for severe cases.
- A new study explores a treatment using TSG6-modified exosomes combined with an injectable thermosensitive hydrogel to reduce endometrium fibrosis in a mouse model of IUA.
- The findings suggest that this method inhibits inflammatory responses and helps maintain a healthy balance of immune cells, ultimately decreasing both the occurrence and severity of IUA.
Photodegradation via ultraviolet (UV) radiation is an important factor driving plant litter decomposition. Despite increasing attention to the role of UV photodegradation in litter decomposition, the specific impact of UV radiation on the plant litter decomposition stage within biogeochemical cycles remains unclear at regional and global scales. To clarify the variation rules of magnitude of UV effect on plant litter decomposition and their regulatory factors, we conducted a meta-analysis based on 54 published papers.
View Article and Find Full Text PDFBackground: Ovarian stimulation (OS) during assisted reproductive technology (ART) appears to be an independent factor influencing the risk of low birth weight (LBW). Previous studies identified the association between LBW and placenta deterioration, potentially resulting from disturbed genomic DNA methylation in oocytes caused by OS. However, the mechanisms by which OS leads to aberrant DNA methylation patterns in oocytes remains unclear.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to identify biomarkers for endometriosis and create a diagnostic model validated by clinical samples.
- Researchers utilized public data and machine learning to fashion a nine-gene panel called EMScore, effectively differentiating between endometriosis patients and healthy individuals.
- The model demonstrated high accuracy, achieving receiver operator characteristic curve values of 0.920 for tissue samples and 0.942 for blood samples, confirming its potential as a reliable diagnostic tool.
Article Synopsis
- Styrax shows potential in preventing and treating cerebrovascular diseases, yet the precise mechanisms of its protective effects against ischemic strokes are not fully understood.
- In a study using a rat model of ischemic stroke, different doses of styrax were administered, revealing significant reductions in cerebral infarct volume and improvement in neurological function, particularly at the highest dose of 0.4 g/kg.
- Styrax treatment positively influenced various biochemical markers related to oxidative stress and inflammation, while also affecting key metabolic processes, suggesting that its protective effects may stem from its role in energy and glutamine metabolism.
Purpose: Plant secondary metabolites are used to treat various human diseases. However, it is difficult to produce a large number of specific metabolites, which largely limits their medicinal applications. Many methods, such as drought and nutrient application, have been used to induce the biosynthetic production of secondary metabolites.
View Article and Find Full Text PDFCoexisting salt and alkaline stresses seriously threaten plant survival. Most studies have focused on halophytes; however, knowledge on how plants defend against saline-alkali stress is limited. This study investigated the role of in a community under environmental saline-alkali stress to analyse the response of elements and metabolites in , using as a control.
View Article and Find Full Text PDFObjective: To summarise the clinical characteristics of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis syndrome (SJS/TEN) and analyse the efficacy and safety of systemic glucocorticoid therapy.
Methods: This study was a retrospective study of 56 patients with SJS/TEN who had been systematically treated with glucocorticoids in the dermatology ward of Peking University Third Hospital from 2010 to 2020. The clinical characteristics, treatment regimen, effects on underlying diseases, incidence and outcome of hormone-related adverse reactions and skin lesion prognosis were summarised and analysed for each patient.
Fusarium wilt is one of the most destructive and less controllable diseases in melon, which is usually caused by . In this study, transcriptome sequencing and Yeast Two-Hybrid (Y2H) methods were used for quantification of differentially expressed genes (DEGs) involved in (f. sp.
View Article and Find Full Text PDFArticle Synopsis
- Kaposi's sarcoma (KS) is a type of cancer that originates from blood vessel cells and typically manifests as skin lesions, primarily affecting the face, mouth, and genitals.
- A unique case was identified where a patient, who was HIV-negative, presented with KS primarily in the nasal mucosa and nasal septum, which is quite rare.
- The treatment involved surgical removal and chemotherapy, resulting in no recurrence after 6 months; the study also suggests considering antiviral therapy to enhance survival and quality of life for patients.
Article Synopsis
- - The pilot study explored the effectiveness of digital image-based psoriasis assessments (DIB-PASI) compared to traditional face-to-face assessments (FTF-PASI) to determine if remote evaluations could be reliable for clinical trials in psoriasis patients of various skin tones and assessor experience levels.
- - Fourteen subjects with moderate-to-severe plaque psoriasis were treated and assessed at different intervals, and both DIB-PASI and FTF-PASI scores were analyzed for concordance, revealing a strong agreement between the two methods (ICC 0.82).
- - The results indicate that DIB-PASI assessments can provide reliable results comparable to FTF-PASI for patients with light and medium-to-dark skin, regardless of the assessor’s training level, suggesting
Article Synopsis
- The study aimed to assess how a personalized 1-week nutrition intervention affects swallowing abilities and nutritional status in stroke patients with dysphagia.
- Participants were divided into a control group receiving standard nutritional support and an intervention group that received additional individualized care, including specialized swallowing tests.
- Results showed that the intervention group had significantly better improvements in swallowing function, serum protein and albumin levels, and lean tissue mass compared to the control group.
Article Synopsis
- Soil salinization is a major issue impacting agroforestry, as it leads to metal ion accumulation and alters plant health; this study compares the metabolic responses of two salt-tolerant species, Suaeda salsa and Puccinellia tenuiflora.
- Using metabolomics and GC-MS analysis, 68 distinct metabolites were identified; P. tenuiflora is better at utilizing sugars for survival, while S. salsa primarily relies on amino acids, alcohols, and acids to cope with saline-alkali conditions.
- The findings reveal that S. salsa defends against saline stress using its aboveground structures, while P. tenuiflora mitigates toxicity through its root system, demonstrating that S. salsa enhances habitat suitability for
Article Synopsis
- Soil salinization stresses plants and limits agricultural productivity, with previous research focusing mainly on individual plant responses rather than plant communities.
- This study investigates two plant communities in the Hulun Buir Grassland, analyzing differences in ion transport and phenolic compound accumulation under saline-alkali stress.
- Findings reveal that one community accumulates potassium and calcium for better salt management, while the other primarily accumulates manganese, enhancing stress resistance through specific compounds that help signal and eliminate stress effects.
Article Synopsis
- Certain species have gained interest for their cancer treatment potential, but their study is complicated by their diversity, slow growth, and endangered status.
- In China, key species include (), (), and × (), primarily found in the northeastern region.
- Utilizing gas chromatography-mass spectrometry (GC-MS), the study identified 162 compounds in the leaves of these species, with 20 significant bioactive metabolites showing various health benefits, including strong antibiotic and anticancer properties in one species and diverse anti-aging effects in another.
Article Synopsis
- Mechanical damage affects plant growth, with younger leaves at greater risk of causing overall damage to the plant compared to older leaves, as demonstrated in the study of Catharanthus roseus.
- The study utilized advanced metabolomics techniques to show that mechanical damage leads to changes in energy allocation and metabolic responses, with different strategies observed in younger and older leaves.
- Findings revealed that older leaves enhance defensive responses through phenolic accumulation, while younger leaves increase damage tolerance, highlighting the trade-offs in energy expenditure between growth, repair, and defense.