The association between triglyceride to high-density-lipoprotein cholesterol ratio and calcific aortic valve disease: a retrospective study.

Background: The ratio of triglycerides to high-density-lipoprotein cholesterol (TG/HDL-C) is increasingly recognized as a practical marker for insulin resistance and cardiovascular risk assessment. This retrospective study investigates the potential of the TG/HDL-C ratio to predict the development of calcific aortic valve disease (CAVD), thereby extending its applicability in cardiovascular diagnostics.

Methods: Data from 400 individuals, comprising 200 patients with diagnosed CAVD and 200 matched healthy controls, were analyzed.

Hyperuricaemia, gout and related adverse events associated with antihypertensive drugs: A real-world analysis using the FDA adverse event reporting system.

The role of antihypertensive drugs in inducing hyperuricaemia and gout has been a long-term concern in clinical practice. However, clinical studies regarding this issue are limited in number and have yielded inconsistent results. We comprehensively evaluated the association between various antihypertensive drugs and the occurrences of hyperuricaemia, gout and related adverse events (AEs) using the FDA Adverse Event Reporting System (FAERS), aiming to guide the selection of antihypertensive drugs with a goal of minimizing the risk of hyperuricaemia, gout and related AEs.

The Microstructural Evolution and Grain Growth Kinetics of Fine-Grained Extruded Mg-Nd-Zn-Zr Alloy.

The microstructure evolution and grain growth kinetics of the fine-grained extruded Mg-Nd-Zn-Zr alloy were investigated by holding the extruded plate for a wide range of time in the temperature range of 470 °C to 530 °C. By observing the optical micrographs, it was found that the material showed abnormal grain growth at the experimental condition of 470 °C × 24 h, and the time point of abnormal grain growth appeared significantly earlier with the increase in the experimental temperature. The evaluation of the second phase content within the alloy indicates that the presence of the second phase contributes to the microstructural stability of the Mg-Nd-Zn-Zr alloy.

Ovary and uterus related adverse events associated with statin use: an analysis of the FDA Adverse Event Reporting System.

Experimental studies have demonstrated statin-induced toxicity for ovary and uterus. However, the safety of statins on the functions of ovary and uterus in real-world clinical settings remains unknown. The aim of this study was to identify ovary and uterus related adverse events (AEs) associated with statin use by analyzing data from FDA Adverse Event Reporting System (FAERS).

A Novel Extrusion for Manufacturing TiBw/Ti6Al4V Composite Tubes with a Quasi-Continuous Reinforced Structure.

The present work introduces a novel extrusion with filler material to produce the high-performance TiBw/Ti-6Al-4V composite tube with a quasi-continuous reinforced structure. A simulation was adopted to study the effect of the filler material on the shape accuracy of the tubes. Based on the simulation results, the flow stress of the filler material was not the important factor, but the friction coefficient between the filler and TiBw/Ti-6Al-4V composite and the canning shape were critical to the tube precision.