Adipokines are important for the thermogenesis (heat production) in beige fat cells, but the specific processes are still unclear.* !
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This study reveals that signaling between VEGFB and VEGFR1 enhances thermogenesis in white adipose tissue (WAT), with VEGFB increasing in fat cells and VEGFR1 in macrophages when thermogenesis is activated.* !
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Removing VEGFB from fat cells reduces browning in WAT, while adding VEGFB boosts thermogenesis, but this effect is negated if VEGFR1 in macrophages is knocked out; the study also shows how VEGFB influences signaling pathways to promote norepinephrine clearance in macrophages.* !