Publications by authors named "Xuexuan Li"

Micro-stereolithography (μSL) is an advanced additive manufacturing technique that enables the fabrication of highly precise microstructures with fine feature resolution. One of the primary challenges in μSL is achieving and maintaining precise focus throughout the fabrication process. For the successful application of μSL, it is essential to maintain the sample surface within a focal depth of several microns.

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Article Synopsis
  • Self-assembly of hydrogels is being researched as a treatment for traumatic brain injury (TBI) but traditional methods face issues with safety and clinical application due to reliance on high molecular carriers and inactive substances.
  • A novel small molecule hydrogel (GBR-gel) uses compounds from Chinese medicines to deliver drugs without the need for additional inactive components, making it easier and cheaper to produce.
  • GBR-gel shows promise in quickly addressing TBI by improving synapse function and reducing inflammation, offering a new potential treatment strategy for brain injuries.
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Article Synopsis
  • Xuefu Zhuyu decoction (XFZYD) is recognized for its ability to enhance blood circulation and provides neuroprotection in cases of severe traumatic brain injury (sTBI), though its specific mechanisms remain largely unknown.
  • The study aimed to explore these neuroprotective effects of XFZYD through a focus on the regulation of specific miRNA and mRNA interactions, utilizing a combination of transcriptomics, bioinformatics, and experimental methods.
  • Results indicated that XFZYD significantly protects against sTBI in rats by regulating the rno-miR-191a-5p/BDNF axis, highlighting its potential therapeutic role in treating brain injuries.
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Scanning probe lithography (SPL) is a promising technology to fabricate high-resolution, customized and cost-effective features at the nanoscale. However, the quality of nano-fabrication, particularly the critical dimension, is significantly influenced by various SPL fabrication techniques and their corresponding process parameters. Meanwhile, the identification and measurement of nano-fabrication features are very time-consuming and subjective.

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The atomic force microscopy (AFM) is an important tool capable of characterization, measurement, and manipulation at the nanoscale with a vertical resolution of less than 0.1 nm. However, the conventional AFMs' scanning range is around 100 µm, which limits their capability for processing cross-scale samples.

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Xuefu Zhuyu decoction (XFZYD) is used to treat traumatic brain injury (TBI). XFZYD-based therapies have achieved good clinical outcomes in TBI. However, the underlying mechanisms of XFZYD in TBI remedy remains unclear.

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Background: Xuefu Zhuyu Decoction (XFZYD), a well-known traditional Chinese medicine prescription, has been widely used to treat traumatic brain injury (TBI). However, the underlying mechanisms involved in XFZYD therapy remain unclear.

Aim Of The Study: We explored new therapeutic targets of XFZYD in TBI by the tsRNA-sequencing (tsRNA-seq) method.

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Traumatic brain injury (TBI) is a complex injury with a multi-faceted recovery process. Long non-coding RNAs (lncRNAs) are demonstrated to be involved in central nervous system (CNS) disorders. However, the roles of lncRNAs in long-term neurological deficits post-TBI are poorly understood.

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