Applications of Chitosan and its Derivatives in the Treatment of Osteoarthritis.

Osteoarthritis (OA) is a common joint disease, which is mainly characterized by the degeneration of articular cartilage, inflammation of the synovial membrane of the joint, and changes in the surrounding bone tissue. With the increase of age and weight, the incidence of OA gradually increases, which seriously affects the quality of life of patients. The primary pharmacological treatments for OA include analgesics and non-steroidal anti-inflammatory drugs.

Bio-Based Vitrimeric Silicone Materials with High-Strength, Reprocessable, Healing, and Transparent Properties.

Developing reprocessable polymeric materials from earth-abundant elements and renewable biomass is attractive for dealing with fossil resource crisis and achieving sustainable development. Based on the unique reactivity of biomass-derived gluconolactone, polydimethylsiloxane (PDMS) terminated with glucosamide groups is synthesized and used for preparing a series of silicone boronic ester based vitrimers. The whole preparation process is quite straightforward without any purification required and highly efficient with water as the only byproduct.