Discovery of New Inhibitors to Attenuate Migratory Capability of Colon Cancer Cells by the Drug Repositioning Strategy.

Recent studies revealed that intestinal microbiota played important roles in colorectal cancer (CRC) carcinogenesis. Particularly, was confirmed to promote the proliferation and metastasis of CRC. Therefore, targeting may be a potential preventive and therapeutic approach for CRC.

Discovery of potent natural product higenamine derivatives as novel Anti-Fusobacterium nucleatum agents.

Fusobacterium nucleatum (F. nucleatum) is closely associated with the occurrence and development of colorectal cancer (CRC). Discovery of specific antibacterial agents against F.

A lanthanide-based high-sensitivity fluorescence method for the on-site rapid detection of thermostable direct hemolysin of Vibrio parahaemolyticus.

Vibrio parahaemolyticus is a common foodborne pathogen in seafood, which often causes seafood borne bacterial gastroenteritis or food poisoning. Thermostable direct hemolysin (TDH) is considered to be one of the main virulence factors involved in this pathogen. The most clinical V.

[Microneedle-based percutaneous immunity: a review].

Microneedle percutaneous immunization is achieved by puncturing the stratum corneum of the skin with microneedles so that the vaccine is efficiently recognized by antigen-presenting cells to induce a specific immune response. Due to the advantages of efficient induction of immune response, low pain and easy storage, transdermal immunization by microneedles has been widely used for immunization of various vaccines in recent years. This review summarizes the materials of microneedles, application for transcutaneous immunization, as well as the challenges that need to be addressed.

A Self-Driven Microfluidic Chip for Ricin and Abrin Detection.

Ricin and abrin are phytotoxins that can be easily used as biowarfare and bioterrorism agents. Therefore, developing a rapid detection method for both toxins is of great significance in the field of biosecurity. In this study, a novel nanoforest silicon microstructure was prepared by the micro-electro-mechanical systems (MEMS) technique; particularly, a novel microfluidic sensor chip with a capillary self-driven function and large surface area was designed.

Assessment of heavy metal pollution in Red River surface sediments, Vietnam.

Surface sediment samples were collected from upstream down to the subaqueous delta of the Red River in Vietnam to assess heavy metal pollution. Sediment Cr and V concentrations are strongly correlated with Al, Fe, Mn and total organic carbon concentrations, as well as particle size, suggesting that these two metals are derived primarily from natural sources and enriched in the fine fraction of sediments. In contrast, Cu, Cd, Pb, Ni and Zn concentrations show weaker correlations with particle size, with very high concentrations observed at several sites in the upper reach of the river, pointing to anthropogenic input as a possible source of these heavy metals.