Publications by authors named "Xuexian Wang"
Clin Pharmacol Ther
October 2024
Article Synopsis
- Vincristine can lead to vincristine-induced peripheral neuropathy (VIPN) in children with acute lymphoblastic leukemia (ALL), and this study aimed to understand the factors that affect its pharmacokinetics and pharmacodynamics.
- A total of 79 pediatric patients were analyzed, revealing that certain genetic factors and interactions with other drugs, like posaconazole, significantly influence the metabolism of vincristine and its association with VIPN risk.
- The research suggests that monitoring vincristine levels during treatment is vital for adjusting dosages and personalizing therapy to mitigate the risk of VIPN.
