Study on the adverse effect of acid-corrosion on the dentin in terms of degradation of fracture resistance.

Human dentin is known for its hierarchical structure through long-term evolution. Dental caries, embodied by dentin demineralization, is ascribed to a different reaction between peritubular dentin (PTD) and intertubular dentin (ITD) to acid dissolution. This study sheds light on the adverse effect of acid on dentin in terms of degradation of its fracture toughness (FT) due to the acid dissolution-induced corrosion of PTD.

Atomic force microscopy-based assessment of multimechanical cellular properties for classification of graded bladder cancer cells and cancer early diagnosis using machine learning analysis.

Cellular mechanical properties (CMPs) have been frequently reported as biomarkers for cell cancerization to assist objective cytology, compared to the current subjective method dependent on cytomorphology. However, single or dual CMPs cannot always successfully distinguish every kind of malignant cell from its benign counterpart. In this work, we extract 4 CMPs of four different graded bladder cancer (BC) cell lines by AFM (atomic force microscopy)-based nanoindentation to generate a CMP database, which is used to train a cancerization-grade classifier by machine learning.